SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'INI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 10 GLY A  20
VAL A  53
GLY A  55
THR A  27
VAL A  18
 None
None
INI  A 200 (-3.4A)
None
None
 1.28A 1v3qE-1rvvA:
3.0		 1v3qE-1rvvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 11 GLY A  55
ILE A  59
GLU A  58
PHE A  57
ALA A  96
 INI  A 200 (-3.4A)
None
INI  A 200 (-2.7A)
INI  A 200 (-4.9A)
None
 1.12A 3nmuB-1rvvA:
undetectable
3nmuJ-1rvvA:
undetectable		 3nmuB-1rvvA:
17.38
3nmuJ-1rvvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 7 HIS A  22
ILE A  25
PRO A 117
HIS A 126
 INI  A 201 ( 4.9A)
None
None
None
 1.04A 4g5jA-2obxA:
undetectable		 4g5jA-2obxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2f59 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Brucella
abortus) 		5 / 12 GLU A 123
LEU A  30
ALA A  20
PHE A  91
ILE A 117
 None
None
INI  A 201 ( 3.7A)
INI  A 201 (-4.0A)
None
 1.29A 4xe5A-2f59A:
undetectable		 4xe5A-2f59A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 8 ALA A  55
HIS A  22
HIS A  88
THR A 116
 INI  A 201 (-3.4A)
INI  A 201 ( 4.9A)
None
None
 1.30A 5db5A-2obxA:
undetectable
5db5B-2obxA:
undetectable		 5db5A-2obxA:
18.70
5db5B-2obxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Mesorhizobium
loti) 		4 / 8 PRO A  59
ILE A  96
VAL A 114
TYR A  56
 None
None
None
INI  A 201 (-4.7A)
 0.85A 5mzrE-2obxA:
2.4		 5mzrE-2obxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 12 GLY A  79
VAL A  81
GLY A 114
ILE A  75
ALA A 103
 None
INI  A 200 (-3.2A)
None
None
None
 1.02A 5x7fA-1rvvA:
undetectable		 5x7fA-1rvvA:
19.20