SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 12 ALA A  47
PHE A 362
ILE A 345
LEU A 430
ILE A 361
THR A  53
 IMP  A 500 (-3.6A)
None
None
None
None
None
 1.37A 1drbB-5uzeA:
undetectable		 1drbB-5uzeA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 7 MET B  88
SER B 341
SER B 343
ILE B 344
 IMP  B1527 (-4.0A)
None
IMP  B1527 (-2.6A)
None
 1.07A 1fxhA-4af0B:
undetectable
1fxhB-4af0B:
undetectable		 1fxhA-4af0B:
17.13
1fxhB-4af0B:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 701 ( 4.6A)
None
 1.26A 1hbpA-4fxsA:
undetectable		 1hbpA-4fxsA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 501 (-4.4A)
None
 1.18A 1hbpA-4ix2A:
undetectable		 1hbpA-4ix2A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 11 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 314
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
 0.82A 1jr1A-1lrtA:
46.0		 1jr1A-1lrtA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 ASP A 253
ASN A 282
GLY A 305
CYH A 310
GLY A 392
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-2.9A)
 1.16A 1jr1A-1zfjA:
51.9		 1jr1A-1zfjA:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 11 ASP A 253
ASN A 282
GLY A 305
CYH A 310
THR A 312
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
None
IMP  A 500 (-3.0A)
 0.59A 1jr1A-1zfjA:
51.9		 1jr1A-1zfjA:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		7 / 11 ASP B 288
ASN B 317
ARG B 336
MET B 339
GLY B 340
CYH B 345
GLY B 427
 MOA  B1526 (-3.3A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-3.6A)
None
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 (-3.2A)
 1.19A 1jr1A-4af0B:
57.1		 1jr1A-4af0B:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		10 / 11 ASP B 288
SER B 289
SER B 290
ASN B 317
ARG B 336
MET B 339
GLY B 340
CYH B 345
GLY B 429
GLN B 470
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-3.6A)
None
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 ( 3.3A)
MOA  B1526 ( 3.7A)
 0.62A 1jr1A-4af0B:
57.1		 1jr1A-4af0B:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		6 / 11 SER B 290
ASN B 317
MET B 339
GLY B 340
GLY B 471
GLN B 470
 MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
None
MOA  B1526 (-4.0A)
IMP  B1527 (-3.1A)
MOA  B1526 ( 3.7A)
 1.17A 1jr1A-4af0B:
57.1		 1jr1A-4af0B:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ASP A 250
SER A 251
GLY A 302
CYH A 307
THR A 309
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
 1.12A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ASP A 250
SER A 252
GLY A 302
CYH A 307
THR A 309
 MOA  A 702 (-3.2A)
MOA  A 702 (-2.8A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
 0.93A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 SER A 251
ASN A 279
GLY A 302
CYH A 307
THR A 309
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
IMP  A 701 (-3.2A)
 0.80A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
GLY A 391
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
IMP  A 701 (-3.2A)
 0.64A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 ASP A 250
SER A 251
ASN A 279
GLY A 302
CYH A 307
THR A 309
 None
None
IMP  A 501 ( 4.4A)
None
IMP  A 501 (-4.9A)
None
 0.95A 1jr1A-4ix2A:
49.0		 1jr1A-4ix2A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 ASP A 250
SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
 None
None
IMP  A 501 ( 4.4A)
None
IMP  A 501 (-4.9A)
None
 0.79A 1jr1A-4ix2A:
49.0		 1jr1A-4ix2A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 11 ASN A 273
GLY A 296
CYH A 301
THR A 303
GLY A 385
 IMP  A 500 ( 4.1A)
None
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
IMP  A 500 ( 3.3A)
 0.35A 1jr1A-4mz1A:
53.8		 1jr1A-4mz1A:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 11 ASP A 244
ASN A 273
GLY A 296
THR A 303
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
2F1  A 501 (-4.1A)
IMP  A 500 ( 3.3A)
 0.78A 1jr1A-4mz1A:
53.8		 1jr1A-4mz1A:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 11 ASP A 244
SER A 245
GLY A 296
THR A 303
GLY A 385
 None
None
None
2F1  A 501 (-4.1A)
IMP  A 500 ( 3.3A)
 1.15A 1jr1A-4mz1A:
53.8		 1jr1A-4mz1A:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 11 SER A 245
GLY A 296
CYH A 301
THR A 303
GLY A 385
 None
None
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
IMP  A 500 ( 3.3A)
 0.70A 1jr1A-4mz1A:
53.8		 1jr1A-4mz1A:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 276
GLY A 299
CYH A 304
THR A 306
GLY A 388
 IMP  A 501 ( 4.3A)
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
IMP  A 501 (-3.1A)
 0.36A 1jr1A-5ahmA:
52.9		 1jr1A-5ahmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 ASN A 173
GLY A 196
CYH A 201
THR A 203
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
AUN  A 401 ( 3.2A)
 0.58A 1jr1A-5ou3A:
48.5		 1jr1A-5ou3A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 ASP A 143
ASN A 173
GLY A 196
CYH A 201
THR A 203
 AUN  A 401 (-3.5A)
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
 0.86A 1jr1A-5ou3A:
48.5		 1jr1A-5ou3A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 ASN A 280
GLY A 303
CYH A 308
THR A 310
GLY A 392
 IMP  A 500 ( 4.3A)
None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
IMP  A 500 ( 3.3A)
 0.42A 1jr1A-5upyA:
50.0		 1jr1A-5upyA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 ASP A 251
ASN A 280
GLY A 303
CYH A 308
THR A 310
 None
IMP  A 500 ( 4.3A)
None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
 0.78A 1jr1A-5upyA:
50.0		 1jr1A-5upyA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 ASN A 280
GLY A 303
CYH A 308
THR A 310
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
IMP  A 501 ( 3.2A)
 0.38A 1jr1A-5uuwA:
50.7		 1jr1A-5uuwA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 ASP A 251
GLY A 303
CYH A 308
THR A 310
GLY A 392
 None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
IMP  A 501 ( 3.2A)
 0.72A 1jr1A-5uuwA:
50.7		 1jr1A-5uuwA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 11 ASN A 275
GLY A 298
CYH A 303
THR A 305
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
IMP  A 500 ( 3.1A)
 0.38A 1jr1A-5uzeA:
52.0		 1jr1A-5uzeA:
33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 263
ASN A 291
GLY A 314
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
 0.37A 1jr1B-1lrtA:
45.9		 1jr1B-1lrtA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A 253
ASN A 282
GLY A 305
THR A 312
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.53A 1jr1B-1zfjA:
52.0		 1jr1B-1zfjA:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 8 ASP B 288
ASN B 317
ARG B 336
GLY B 340
GLY B 427
 MOA  B1526 (-3.3A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.2A)
 1.06A 1jr1B-4af0B:
57.3		 1jr1B-4af0B:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 8 ASP B 288
ASN B 317
ARG B 336
GLY B 342
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-3.6A)
IMP  B1527 (-3.3A)
IMP  B1527 ( 3.3A)
 1.10A 1jr1B-4af0B:
57.3		 1jr1B-4af0B:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		7 / 8 ASP B 288
SER B 290
ASN B 317
ARG B 336
GLY B 340
GLY B 429
GLN B 470
 MOA  B1526 (-3.3A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 ( 3.3A)
MOA  B1526 ( 3.7A)
 0.27A 1jr1B-4af0B:
57.3		 1jr1B-4af0B:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 279
GLY A 302
THR A 309
GLY A 391
 MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
MOA  A 702 (-3.4A)
IMP  A 701 (-3.2A)
 0.39A 1jr1B-4fxsA:
53.3		 1jr1B-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 SER A 252
ASN A 279
GLY A 302
GLY A 391
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.2A)
 0.63A 1jr1B-4fxsA:
53.3		 1jr1B-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASP A 250
ASN A 279
GLY A 302
THR A 309
 None
IMP  A 501 ( 4.4A)
None
None
 0.60A 1jr1B-4ix2A:
48.7		 1jr1B-4ix2A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASP A 250
SER A 252
ASN A 279
GLY A 302
 None
None
IMP  A 501 ( 4.4A)
None
 0.87A 1jr1B-4ix2A:
48.7		 1jr1B-4ix2A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		4 / 8 ASN A 273
GLY A 296
THR A 303
GLY A 385
 IMP  A 500 ( 4.1A)
None
2F1  A 501 (-4.1A)
IMP  A 500 ( 3.3A)
 0.30A 1jr1B-4mz1A:
53.6		 1jr1B-4mz1A:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		4 / 8 ASP A 244
ASN A 273
GLY A 296
THR A 303
 None
IMP  A 500 ( 4.1A)
None
2F1  A 501 (-4.1A)
 0.82A 1jr1B-4mz1A:
53.6		 1jr1B-4mz1A:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 276
GLY A 299
THR A 306
GLY A 388
 IMP  A 501 ( 4.3A)
None
IMP  A 501 ( 4.9A)
IMP  A 501 (-3.1A)
 0.30A 1jr1B-5ahmA:
52.8		 1jr1B-5ahmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 ASN A 280
GLY A 303
THR A 310
GLY A 392
 IMP  A 500 ( 4.3A)
None
Q21  A 501 (-4.3A)
IMP  A 500 ( 3.3A)
 0.27A 1jr1B-5upyA:
49.9		 1jr1B-5upyA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 ASN A 280
GLY A 303
THR A 310
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
8N1  A 502 (-3.9A)
IMP  A 501 ( 3.2A)
 0.29A 1jr1B-5uuwA:
50.5		 1jr1B-5uuwA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 8 ASN A 275
GLY A 298
THR A 305
GLY A 387
 IMP  A 500 (-4.0A)
None
8L1  A 501 (-3.9A)
IMP  A 500 ( 3.1A)
 0.27A 1jr1B-5uzeA:
51.7		 1jr1B-5uzeA:
33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 LEU A 337
GLY A 413
GLY A 415
CYH A 331
THR A 333
 None
IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
 1.11A 1likA-1jr1A:
undetectable		 1likA-1jr1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 12 MET A 269
GLY A 183
MET A 240
THR A  57
PHE A 266
 None
IMP  A1338 (-3.4A)
IMP  A1338 (-3.5A)
None
None
 1.41A 1m2zA-2bznA:
undetectable		 1m2zA-2bznA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 ASP A 274
SER A 275
ASN A 303
GLY A 326
CYH A 331
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
IMP  A1331 ( 3.1A)
 0.79A 1me7A-1jr1A:
48.8		 1me7A-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 ASP A 274
SER A 276
ASN A 303
GLY A 326
CYH A 331
GLY A 415
 MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
IMP  A1331 ( 3.1A)
 0.48A 1me7A-1jr1A:
48.8		 1me7A-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
 0.33A 1me7A-1lrtA:
57.8		 1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 8 SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.60A 1me7A-1lrtA:
57.8		 1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASN A 282
ILE A 304
GLY A 305
CYH A 310
GLY A 394
 IMP  A 500 ( 4.5A)
None
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-3.0A)
 0.43A 1me7A-1zfjA:
49.4		 1me7A-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A 253
ILE A 304
GLY A 305
CYH A 310
GLY A 394
 IMP  A 500 ( 4.7A)
None
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-3.0A)
 0.62A 1me7A-1zfjA:
49.4		 1me7A-1zfjA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ASN A 158
ILE A 180
GLY A 181
CYH A 186
 IMP  A1338 ( 4.3A)
None
None
IMP  A1338 (-2.5A)
 0.37A 1me7A-2bznA:
38.0		 1me7A-2bznA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ASP A 129
ILE A 180
GLY A 181
CYH A 186
 None
None
None
IMP  A1338 (-2.5A)
 0.63A 1me7A-2bznA:
38.0		 1me7A-2bznA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 SER A 164
ASN A 191
ILE A 213
GLY A 214
 None
IMP  A 801 ( 4.2A)
None
None
 0.54A 1me7A-3khjA:
42.4		 1me7A-3khjA:
28.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		7 / 8 ASP B 288
SER B 289
SER B 290
ASN B 317
GLY B 340
CYH B 345
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 ( 3.3A)
 0.46A 1me7A-4af0B:
47.8		 1me7A-4af0B:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 279
ILE A 301
GLY A 302
GLY A 389
 MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.1A)
 0.78A 1me7A-4fxsA:
50.2		 1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASP A 250
SER A 251
SER A 252
CYH A 307
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
IMP  A 701 (-3.0A)
 0.67A 1me7A-4fxsA:
50.2		 1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		7 / 8 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
CYH A 307
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
IMP  A 701 (-3.2A)
 0.52A 1me7A-4fxsA:
50.2		 1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 8 ASP A 250
SER A 251
SER A 252
ILE A 301
GLY A 302
CYH A 307
 None
None
None
None
None
IMP  A 501 (-4.9A)
 0.85A 1me7A-4ix2A:
45.7		 1me7A-4ix2A:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 8 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
CYH A 307
 None
None
IMP  A 501 ( 4.4A)
None
None
IMP  A 501 (-4.9A)
 0.61A 1me7A-4ix2A:
45.7		 1me7A-4ix2A:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 8 ASP A 244
SER A 245
ILE A 295
CYH A 301
GLY A 385
 None
None
None
IMP  A 500 ( 3.1A)
IMP  A 500 ( 3.3A)
 0.82A 1me7A-4mz1A:
50.2		 1me7A-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		6 / 8 SER A 245
ASN A 273
ILE A 295
GLY A 296
CYH A 301
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
None
IMP  A 500 ( 3.1A)
IMP  A 500 ( 3.3A)
 0.49A 1me7A-4mz1A:
50.2		 1me7A-4mz1A:
29.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 8 ASN A 276
ILE A 298
GLY A 299
CYH A 304
GLY A 388
 IMP  A 501 ( 4.3A)
None
None
IMP  A 501 (-3.0A)
IMP  A 501 (-3.1A)
 0.43A 1me7A-5ahmA:
49.9		 1me7A-5ahmA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ASN A 173
GLY A 196
CYH A 201
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
AUN  A 401 ( 3.2A)
 0.34A 1me7A-5ou3A:
47.0		 1me7A-5ou3A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 8 ASN A 280
ILE A 302
GLY A 303
CYH A 308
GLY A 392
 IMP  A 500 ( 4.3A)
None
None
IMP  A 500 (-3.2A)
IMP  A 500 ( 3.3A)
 0.41A 1me7A-5upyA:
46.8		 1me7A-5upyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 ASN A 280
ILE A 302
GLY A 303
GLY A 390
 IMP  A 500 ( 4.3A)
None
None
IMP  A 500 (-3.2A)
 0.78A 1me7A-5upyA:
46.8		 1me7A-5upyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 ASP A 251
ILE A 302
GLY A 303
CYH A 308
 None
None
None
IMP  A 500 (-3.2A)
 0.74A 1me7A-5upyA:
46.8		 1me7A-5upyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 8 ASN A 280
ILE A 302
GLY A 303
CYH A 308
GLY A 392
 IMP  A 501 (-4.1A)
None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
IMP  A 501 ( 3.2A)
 0.38A 1me7A-5uuwA:
47.3		 1me7A-5uuwA:
29.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 8 ASN A 275
ILE A 297
GLY A 298
CYH A 303
GLY A 387
 IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
IMP  A 500 ( 3.1A)
 0.45A 1me7A-5uzeA:
48.2		 1me7A-5uzeA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 10 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 ( 3.1A)
 0.75A 1mehA-1jr1A:
47.1		 1mehA-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
 1.17A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
GLY A 316
GLU A 408
GLY A 409
ARG A 414
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.6A)
None
IMP  A 801 ( 3.2A)
None
 1.42A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
 1.28A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 (-3.2A)
 1.32A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
ARG A 414
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
None
 0.85A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		8 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
 0.30A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 SER A 263
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
 1.26A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 SER A 263
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
 0.95A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ASP A 253
ASN A 282
ILE A 304
GLY A 305
GLY A 392
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-2.9A)
 1.04A 1mehA-1zfjA:
47.4		 1mehA-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ASP A 253
ASN A 282
ILE A 304
GLY A 305
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.62A 1mehA-1zfjA:
47.4		 1mehA-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		6 / 10 ASP B 288
SER B 289
SER B 290
ASN B 317
GLY B 340
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 ( 3.3A)
 0.32A 1mehA-4af0B:
47.2		 1mehA-4af0B:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 10 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.2A)
 0.47A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 SER A 252
ASN A 279
ILE A 301
GLY A 302
GLY A 418
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.3A)
 1.29A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 10 ASP A 250
SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
 None
None
None
IMP  A 501 ( 4.4A)
None
None
 0.80A 1mehA-4ix2A:
44.4		 1mehA-4ix2A:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 10 ASP A 244
SER A 245
ILE A 295
GLY A 296
GLY A 385
 None
None
None
None
IMP  A 500 ( 3.3A)
 0.82A 1mehA-4mz1A:
48.4		 1mehA-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 10 SER A 245
ASN A 273
ILE A 295
GLY A 296
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
None
IMP  A 500 ( 3.3A)
 0.51A 1mehA-4mz1A:
48.4		 1mehA-4mz1A:
29.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 8 ASP A 274
SER A 275
ASN A 303
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-3.7A)
IMP  A1331 ( 3.1A)
 0.91A 1meiA-1jr1A:
48.3		 1meiA-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		4 / 8 ASP A 274
SER A 276
ASN A 303
GLY A 415
 MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
IMP  A1331 ( 3.1A)
 0.40A 1meiA-1jr1A:
48.3		 1meiA-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLU A 408
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
None
IMP  A 801 ( 3.2A)
 0.33A 1meiA-1lrtA:
58.5		 1meiA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 SER A 263
ASN A 291
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
IMP  A 801 (-3.2A)
 0.91A 1meiA-1lrtA:
58.5		 1meiA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 8 ASP B 288
SER B 289
SER B 290
ASN B 317
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
IMP  B1527 ( 3.3A)
 0.32A 1meiA-4af0B:
48.1		 1meiA-4af0B:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 8 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
IMP  A 701 (-3.2A)
 0.47A 1meiA-4fxsA:
49.7		 1meiA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 8 ASP A 250
SER A 251
SER A 252
ASN A 279
ILE A 301
 None
None
None
IMP  A 501 ( 4.4A)
None
 0.83A 1meiA-4ix2A:
45.5		 1meiA-4ix2A:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		4 / 8 ASP A 244
SER A 245
ILE A 295
GLY A 385
 None
None
None
IMP  A 500 ( 3.3A)
 0.87A 1meiA-4mz1A:
49.7		 1meiA-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		4 / 8 SER A 245
ASN A 273
ILE A 295
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
IMP  A 500 ( 3.3A)
 0.53A 1meiA-4mz1A:
49.7		 1meiA-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 TYR A 383
GLY A 359
ALA A  47
SER A  48
ILE A 361
 IMP  A 500 (-4.8A)
IMP  A 500 (-3.5A)
IMP  A 500 (-3.6A)
None
None
 1.18A 1nt2A-5uzeA:
undetectable		 1nt2A-5uzeA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 TYR A 405
GLY A 359
GLY A 381
LEU A 380
SER A 317
 IMP  A 801 (-4.6A)
IMP  A 801 (-3.3A)
IMP  A 801 (-3.5A)
None
IMP  A 801 (-2.6A)
 1.19A 1qzzA-1lrtA:
undetectable		 1qzzA-1lrtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 701 ( 4.6A)
None
 1.20A 1rbpA-4fxsA:
undetectable		 1rbpA-4fxsA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ALA A 355
PHE A 461
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 501 (-4.4A)
None
 1.36A 1rbpA-4ix2A:
undetectable		 1rbpA-4ix2A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A  54
ILE A 309
GLY A 422
GLY A 394
ALA A  52
 None
None
IMP  A 500 (-3.1A)
IMP  A 500 (-3.0A)
None
 1.03A 1sguA-1zfjA:
undetectable		 1sguA-1zfjA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 GLY A 301
ARG A 311
ASP A 326
CYH A 327
ASP A 341
 None
None
None
None
IMP  A 500 (-2.6A)
 1.05A 2br4C-5upyA:
undetectable		 2br4C-5upyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 GLY A 301
ARG A 311
ASP A 326
CYH A 327
ASP A 341
 None
None
None
None
IMP  A 501 (-2.4A)
 1.05A 2br4C-5uuwA:
undetectable		 2br4C-5uuwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 TYR B 425
VAL B  91
SER B  86
GLY B 342
ILE B 344
 IMP  B1527 (-4.6A)
None
IMP  B1527 (-2.6A)
IMP  B1527 (-3.3A)
None
 1.41A 2dcfA-4af0B:
undetectable		 2dcfA-4af0B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TYR A 281
VAL A  73
SER A  68
GLY A 198
ILE A 200
 IMP  A 400 (-4.6A)
None
IMP  A 400 (-2.8A)
IMP  A 400 (-3.5A)
None
 1.33A 2dcfA-5ou3A:
undetectable		 2dcfA-5ou3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 11 GLY B 379
SER B 343
ASN B  51
GLY B 382
HIS B 386
 IMP  B1527 (-3.5A)
IMP  B1527 (-2.6A)
None
None
None
 1.28A 2hmaA-4af0B:
undetectable		 2hmaA-4af0B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 LEU A 380
ILE A 361
GLY A 360
GLY A 316
SER A  56
 None
None
IMP  A 801 (-4.1A)
IMP  A 801 (-3.6A)
None
 1.16A 2qmmA-1lrtA:
undetectable		 2qmmA-1lrtA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 9 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 500 (-3.6A)
IMP  A 500 (-3.4A)
None
 0.95A 2qmmA-5upyA:
undetectable		 2qmmA-5upyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 501 (-3.9A)
IMP  A 501 ( 3.2A)
None
 0.97A 2qmmA-5uuwA:
undetectable		 2qmmA-5uuwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 500 (-3.6A)
IMP  A 500 (-3.4A)
None
 0.94A 2qmmA-5upyA:
undetectable
2qmmB-5upyA:
undetectable		 2qmmA-5upyA:
21.04
2qmmB-5upyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 501 (-3.9A)
IMP  A 501 ( 3.2A)
None
 0.96A 2qmmA-5uuwA:
undetectable
2qmmB-5uuwA:
undetectable		 2qmmA-5uuwA:
23.46
2qmmB-5uuwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 4 LYS A 403
ALA A 385
PHE A 384
GLY A 381
 None
None
None
IMP  A 801 (-3.5A)
 1.42A 2rddA-1lrtA:
0.0		 2rddA-1lrtA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 LYS A 385
ALA A 367
PHE A 366
GLY A 363
 None
None
None
IMP  A 701 (-3.7A)
 1.30A 2rddA-4fxsA:
undetectable		 2rddA-4fxsA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 LYS A 385
ALA A 367
PHE A 366
GLY A 363
 None
None
None
IMP  A 501 (-3.5A)
 1.38A 2rddA-4ix2A:
undetectable		 2rddA-4ix2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 LYS A 382
ALA A 364
PHE A 363
GLY A 360
 None
None
None
IMP  A 501 (-3.7A)
 1.44A 2rddA-5ahmA:
undetectable		 2rddA-5ahmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 4 LYS A 386
ALA A 368
PHE A 367
GLY A 364
 None
None
None
IMP  A 501 (-3.7A)
 1.38A 2rddA-5uuwA:
undetectable		 2rddA-5uuwA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 11 ALA B 433
MET B  88
GLY B 471
ILE B 344
VAL B 476
 None
IMP  B1527 (-4.0A)
IMP  B1527 (-3.1A)
None
None
 1.15A 2uxpB-4af0B:
undetectable		 2uxpB-4af0B:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 6 PHE A 266
ALA A  53
LEU A 245
ALA A 246
 None
IMP  A1338 (-3.4A)
None
None
 0.93A 2vcvB-2bznA:
undetectable		 2vcvB-2bznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 6 PHE A 266
ALA A  53
LEU A 245
ALA A 246
 None
IMP  A1338 (-3.4A)
None
None
 0.93A 2vcvK-2bznA:
undetectable		 2vcvK-2bznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 290
VAL A  55
SER A  63
ASP A 358
ASP A 261
 None
None
None
IMP  A 801 (-2.5A)
TAD  A 901 (-2.3A)
 1.42A 2vqyA-1lrtA:
0.1		 2vqyA-1lrtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 VAL A 338
ARG A 329
ASN A 291
GLY A 290
 None
None
IMP  A 801 ( 4.6A)
None
 0.83A 2y05A-1lrtA:
undetectable
2y05B-1lrtA:
undetectable		 2y05A-1lrtA:
22.08
2y05B-1lrtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.15A 3a51A-1zfjA:
undetectable		 3a51A-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 ILE A  46
ASN A 280
ILE A 344
PRO A  45
LEU A 354
 None
IMP  A 500 ( 4.3A)
None
None
None
 1.24A 3a51A-5upyA:
undetectable		 3a51A-5upyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.17A 3a51C-1zfjA:
undetectable		 3a51C-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.17A 3a51D-1zfjA:
undetectable		 3a51D-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.17A 3a51E-1zfjA:
undetectable		 3a51E-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 TYR B 425
VAL B  91
SER B  86
GLY B 342
ILE B 344
 IMP  B1527 (-4.6A)
None
IMP  B1527 (-2.6A)
IMP  B1527 (-3.3A)
None
 1.44A 3a65A-4af0B:
undetectable		 3a65A-4af0B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TYR A 281
VAL A  73
SER A  68
GLY A 198
ILE A 200
 IMP  A 400 (-4.6A)
None
IMP  A 400 (-2.8A)
IMP  A 400 (-3.5A)
None
 1.39A 3a65A-5ou3A:
undetectable		 3a65A-5ou3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 131
ILE A 130
LYS A 133
LEU A 175
TYR A 180
 None
None
IMP  A1210 (-3.0A)
None
None
 1.45A 3gwxB-1yfzA:
undetectable		 3gwxB-1yfzA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Caldanaerobacter
subterraneus) 		3 / 3 ARG A 136
ASP A 132
ASP A 105
 None
None
IMP  A1210 (-4.2A)
 0.85A 3jayA-1yfzA:
3.0		 3jayA-1yfzA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A 337
ASN A 276
VAL A 245
ILE A  69
ARG A 456
 IMP  A 501 (-2.6A)
IMP  A 501 ( 4.3A)
None
None
None
 1.21A 3n23A-5ahmA:
undetectable		 3n23A-5ahmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB
(Escherichia
coli) 		3 / 3 PHE A 154
LYS A 177
SER A 178
 IMP  A3036 (-3.8A)
IMP  A3036 (-2.7A)
None
 1.25A 3tyeB-2pyuA:
undetectable		 3tyeB-2pyuA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ASP A 251
ILE A 339
GLY A  50
ALA A  49
VAL A 249
 None
None
None
IMP  A 500 (-3.4A)
None
 0.90A 3uq6B-5upyA:
undetectable		 3uq6B-5upyA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ASP A 251
ILE A 339
GLY A  50
ALA A  49
VAL A 249
 None
None
None
IMP  A 501 (-3.2A)
None
 1.06A 3uq6B-5uuwA:
2.2		 3uq6B-5uuwA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ASP A 251
ILE A 339
GLY A  50
ALA A  49
VAL A 249
 None
None
None
IMP  A 500 (-3.4A)
None
 0.92A 3vaqB-5upyA:
undetectable		 3vaqB-5upyA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ASP A 251
ILE A 339
GLY A  50
ALA A  49
VAL A 249
 None
None
None
IMP  A 501 (-3.2A)
None
 1.08A 3vaqB-5uuwA:
undetectable		 3vaqB-5uuwA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 ASP A 274
ASN A 303
ARG A 322
MET A 325
GLY A 413
 MOA  A1332 (-3.5A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 (-3.5A)
 0.95A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		8 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
GLY A 415
GLN A 441
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 ( 3.1A)
MOA  A1332 ( 3.8A)
 0.52A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 8 SER A 276
ASN A 303
MET A 325
GLY A 442
GLN A 441
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
None
IMP  A1331 (-3.0A)
MOA  A1332 ( 3.8A)
 1.09A 4af0A-1jr1A:
57.1		 4af0A-1jr1A:
56.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
 0.42A 4af0A-1lrtA:
45.3		 4af0A-1lrtA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 SER A 251
SER A 252
ASN A 279
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
IMP  A 701 (-3.2A)
 0.50A 4af0A-4fxsA:
51.3		 4af0A-4fxsA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASP A 250
SER A 251
SER A 252
ASN A 279
 None
None
None
IMP  A 501 ( 4.4A)
 0.74A 4af0A-4ix2A:
45.8		 4af0A-4ix2A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 10 ASP A 274
ASN A 303
ARG A 322
MET A 325
MET A 414
GLY A 413
 MOA  A1332 (-3.5A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
None
IMP  A1331 (-3.5A)
 1.37A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		9 / 10 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
MET A 414
GLY A 415
GLN A 441
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
None
IMP  A1331 ( 3.1A)
MOA  A1332 ( 3.8A)
 0.52A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 10 SER A 276
ASN A 303
ARG A 322
MET A 414
GLY A 413
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.6A)
None
IMP  A1331 (-3.5A)
 1.36A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 10 SER A 276
ASN A 303
MET A 325
GLY A 442
GLN A 441
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
None
IMP  A1331 (-3.0A)
MOA  A1332 ( 3.8A)
 1.10A 4af0B-1jr1A:
57.1		 4af0B-1jr1A:
56.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
 0.41A 4af0B-1lrtA:
45.3		 4af0B-1lrtA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 SER A 251
SER A 252
ASN A 279
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
None
IMP  A 701 (-3.2A)
 0.54A 4af0B-4fxsA:
51.3		 4af0B-4fxsA:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 ASP A 250
SER A 251
SER A 252
ASN A 279
MET A 390
 None
None
None
IMP  A 501 ( 4.4A)
None
 0.80A 4af0B-4ix2A:
45.7		 4af0B-4ix2A:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 GLY A 365
ALA A 363
THR A 383
ALA A 346
VAL A 347
 IMP  A1331 ( 3.9A)
None
None
None
None
 1.37A 4df3B-1jr1A:
undetectable		 4df3B-1jr1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 SER A 308
TYR A 390
GLY A 344
PRO A 306
 IMP  A 500 (-2.6A)
IMP  A 500 (-4.5A)
IMP  A 500 ( 3.7A)
None
 1.46A 4e3aA-1zfjA:
1.8		 4e3aA-1zfjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 SER A 308
TYR A 390
GLY A 345
PRO A 306
 IMP  A 500 (-2.6A)
IMP  A 500 (-4.5A)
IMP  A 500 (-4.0A)
None
 1.28A 4e3aA-1zfjA:
1.8		 4e3aA-1zfjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 SER A 305
TYR A 387
GLY A 341
PRO A 303
 IMP  A 701 (-2.6A)
IMP  A 701 (-4.6A)
IMP  A 701 (-3.5A)
None
 1.50A 4e3aA-4fxsA:
undetectable		 4e3aA-4fxsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 SER A 305
TYR A 387
GLY A 342
PRO A 303
 IMP  A 701 (-2.6A)
IMP  A 701 (-4.6A)
IMP  A 701 (-3.5A)
None
 1.34A 4e3aA-4fxsA:
undetectable		 4e3aA-4fxsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 SER A 199
TYR A 281
GLY A 235
PRO A 197
 IMP  A 400 (-2.6A)
IMP  A 400 (-4.6A)
IMP  A 400 (-3.5A)
None
 1.47A 4e3aA-5ou3A:
1.9		 4e3aA-5ou3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 SER A 199
TYR A 281
GLY A 236
PRO A 197
 IMP  A 400 (-2.6A)
IMP  A 400 (-4.6A)
IMP  A 400 (-3.6A)
None
 1.31A 4e3aA-5ou3A:
1.9		 4e3aA-5ou3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 4 SER A 306
TYR A 388
GLY A 342
PRO A 304
 IMP  A 500 (-2.6A)
IMP  A 500 (-4.6A)
IMP  A 500 ( 3.7A)
None
 1.46A 4e3aA-5upyA:
undetectable		 4e3aA-5upyA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 4 SER A 306
TYR A 388
GLY A 343
PRO A 304
 IMP  A 500 (-2.6A)
IMP  A 500 (-4.6A)
IMP  A 500 (-3.6A)
None
 1.30A 4e3aA-5upyA:
undetectable		 4e3aA-5upyA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 4 SER A 306
TYR A 388
GLY A 342
PRO A 304
 IMP  A 501 (-2.8A)
IMP  A 501 (-4.7A)
IMP  A 501 (-3.1A)
None
 1.48A 4e3aA-5uuwA:
undetectable		 4e3aA-5uuwA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 4 SER A 306
TYR A 388
GLY A 343
PRO A 304
 IMP  A 501 (-2.8A)
IMP  A 501 (-4.7A)
IMP  A 501 (-3.9A)
None
 1.33A 4e3aA-5uuwA:
undetectable		 4e3aA-5uuwA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 4 SER A 301
TYR A 383
GLY A 337
PRO A 299
 IMP  A 500 (-2.5A)
IMP  A 500 (-4.8A)
IMP  A 500 (-3.4A)
None
 1.46A 4e3aA-5uzeA:
3.0		 4e3aA-5uzeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 4 SER A 301
TYR A 383
GLY A 338
PRO A 299
 IMP  A 500 (-2.5A)
IMP  A 500 (-4.8A)
IMP  A 500 (-3.4A)
None
 1.31A 4e3aA-5uzeA:
3.0		 4e3aA-5uzeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 12 ALA A  47
PHE A 362
ILE A 345
LEU A 430
ILE A 361
THR A  53
 IMP  A 500 (-3.6A)
None
None
None
None
None
 1.44A 4fhbA-5uzeA:
undetectable		 4fhbA-5uzeA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		7 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
THR A 333
MET A 414
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 1.14A 4fo4A-1jr1A:
51.1		 4fo4A-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		7 / 8 SER A 275
SER A 276
ASN A 303
CYH A 331
THR A 333
MET A 414
GLY A 415
 None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.81A 4fo4A-1jr1A:
51.1		 4fo4A-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
CYH A 319
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
 0.88A 4fo4A-1lrtA:
47.0		 4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 SER A 262
SER A 263
ASN A 291
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.69A 4fo4A-1lrtA:
47.0		 4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASN A 282
CYH A 310
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.5A)
IMP  A 500 ( 3.2A)
None
None
IMP  A 500 (-3.0A)
 0.19A 4fo4A-1zfjA:
54.7		 4fo4A-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A 253
ASN A 282
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.84A 4fo4A-1zfjA:
54.7		 4fo4A-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ASN A 158
CYH A 186
THR A 188
MET A 269
 IMP  A1338 ( 4.3A)
IMP  A1338 (-2.5A)
None
None
 0.50A 4fo4A-2bznA:
41.7		 4fo4A-2bznA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		7 / 8 ASP B 288
SER B 289
SER B 290
ASN B 317
CYH B 345
MET B 428
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
IMP  B1527 (-3.3A)
None
IMP  B1527 ( 3.3A)
 0.86A 4fo4A-4af0B:
48.2		 4fo4A-4af0B:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 8 ASP A 250
SER A 251
SER A 252
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.86A 4fo4A-4fxsA:
59.8		 4fo4A-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		7 / 8 SER A 251
SER A 252
ASN A 279
CYH A 307
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.16A 4fo4A-4fxsA:
59.8		 4fo4A-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 8 ASP A 250
SER A 251
SER A 252
ASN A 279
THR A 309
MET A 390
 None
None
None
IMP  A 501 ( 4.4A)
None
None
 0.82A 4fo4A-4ix2A:
57.3		 4fo4A-4ix2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 8 SER A 251
SER A 252
ASN A 279
CYH A 307
THR A 309
MET A 390
 None
None
IMP  A 501 ( 4.4A)
IMP  A 501 (-4.9A)
None
None
 0.46A 4fo4A-4ix2A:
57.3		 4fo4A-4ix2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		7 / 8 ASP A 244
SER A 245
ASN A 273
CYH A 301
THR A 303
MET A 384
GLY A 385
 None
None
IMP  A 500 ( 4.1A)
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
None
IMP  A 500 ( 3.3A)
 0.37A 4fo4A-4mz1A:
55.9		 4fo4A-4mz1A:
59.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 8 ASN A 276
CYH A 304
THR A 306
MET A 387
GLY A 388
 IMP  A 501 ( 4.3A)
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
 0.26A 4fo4A-5ahmA:
55.1		 4fo4A-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 247
THR A 306
MET A 387
GLY A 388
 None
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
 0.88A 4fo4A-5ahmA:
55.1		 4fo4A-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 8 ASN A 173
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.24A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 8 ASP A 143
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 (-3.5A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.77A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 8 ASN A 280
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 500 ( 4.3A)
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
None
IMP  A 500 ( 3.3A)
 0.18A 4fo4A-5upyA:
56.0		 4fo4A-5upyA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 8 ASP A 251
CYH A 308
THR A 310
MET A 391
GLY A 392
 None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
None
IMP  A 500 ( 3.3A)
 0.83A 4fo4A-5upyA:
56.0		 4fo4A-5upyA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 8 ASN A 280
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 501 (-4.1A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
None
IMP  A 501 ( 3.2A)
 0.23A 4fo4A-5uuwA:
56.3		 4fo4A-5uuwA:
63.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 8 ASP A 246
ASN A 275
CYH A 303
THR A 305
MET A 386
GLY A 387
 None
IMP  A 500 (-4.0A)
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.38A 4fo4A-5uzeA:
55.5		 4fo4A-5uzeA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 275
ASN A 303
GLY A 326
CYH A 331
THR A 333
GLY A 415
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 ( 3.1A)
 0.74A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 275
ASN A 303
GLY A 326
THR A 333
MET A 414
GLY A 415
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.69A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 276
ASN A 303
GLY A 326
CYH A 331
THR A 333
GLY A 415
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 ( 3.1A)
 0.53A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 8 SER A 276
ASN A 303
GLY A 326
THR A 333
MET A 414
GLY A 415
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.46A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 8 SER A 262
SER A 263
ASN A 291
GLY A 314
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.66A 4fo4B-1lrtA:
46.3		 4fo4B-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 8 ASN A 282
GLY A 305
CYH A 310
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
None
None
IMP  A 500 (-3.0A)
 0.24A 4fo4B-1zfjA:
51.0		 4fo4B-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 8 ASN A 158
GLY A 181
CYH A 186
THR A 188
MET A 269
 IMP  A1338 ( 4.3A)
None
IMP  A1338 (-2.5A)
None
None
 0.48A 4fo4B-2bznA:
42.0		 4fo4B-2bznA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 SER A 164
ASN A 191
GLY A 214
THR A 221
 None
IMP  A 801 ( 4.2A)
None
None
 0.54A 4fo4B-3khjA:
45.5		 4fo4B-3khjA:
57.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 8 ASN B 317
GLY B 340
CYH B 345
GLY B 427
 MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 (-3.2A)
 0.82A 4fo4B-4af0B:
48.1		 4fo4B-4af0B:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		7 / 8 SER B 289
SER B 290
ASN B 317
GLY B 340
CYH B 345
MET B 428
GLY B 429
 MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
None
IMP  B1527 ( 3.3A)
 0.37A 4fo4B-4af0B:
48.1		 4fo4B-4af0B:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 279
GLY A 341
MET A 390
GLY A 389
 MOA  A 702 (-3.5A)
IMP  A 701 (-3.5A)
None
IMP  A 701 (-3.1A)
 0.88A 4fo4B-4fxsA:
59.5		 4fo4B-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		8 / 8 SER A 251
SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.23A 4fo4B-4fxsA:
59.5		 4fo4B-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		7 / 8 SER A 251
SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
MET A 390
 None
None
IMP  A 501 ( 4.4A)
None
IMP  A 501 (-4.9A)
None
None
 0.43A 4fo4B-4ix2A:
57.2		 4fo4B-4ix2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		7 / 8 SER A 245
ASN A 273
GLY A 296
CYH A 301
THR A 303
MET A 384
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
None
IMP  A 500 ( 3.3A)
 0.31A 4fo4B-4mz1A:
51.3		 4fo4B-4mz1A:
59.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 8 ASN A 276
GLY A 299
CYH A 304
THR A 306
MET A 387
GLY A 388
 IMP  A 501 ( 4.3A)
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
 0.26A 4fo4B-5ahmA:
55.1		 4fo4B-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 8 ASN A 173
GLY A 196
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.32A 4fo4B-5ou3A:
51.9		 4fo4B-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		6 / 8 ASN A 280
GLY A 303
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 500 ( 4.3A)
None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
None
IMP  A 500 ( 3.3A)
 0.22A 4fo4B-5upyA:
52.7		 4fo4B-5upyA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		6 / 8 ASN A 280
GLY A 303
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
None
IMP  A 501 ( 3.2A)
 0.24A 4fo4B-5uuwA:
52.6		 4fo4B-5uuwA:
63.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 8 ASN A 275
GLY A 298
CYH A 303
THR A 305
MET A 386
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.27A 4fo4B-5uzeA:
55.0		 4fo4B-5uzeA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 9 ASP A 274
SER A 275
GLY A 326
CYH A 331
THR A 333
 MOA  A1332 (-3.5A)
None
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
 1.12A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 9 ASP A 274
SER A 276
GLY A 326
CYH A 331
THR A 333
 MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
 0.93A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 9 SER A 275
ASN A 303
GLY A 326
CYH A 331
THR A 333
ASP A 364
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 (-2.8A)
 0.76A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		6 / 9 SER A 276
ASN A 303
GLY A 326
CYH A 331
THR A 333
ASP A 364
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 (-2.8A)
 0.63A 4fxsA-1jr1A:
53.2		 4fxsA-1jr1A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 9 ASP A 261
SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
 0.97A 4fxsA-1lrtA:
46.8		 4fxsA-1lrtA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 9 SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
CYH A 319
ASP A 358
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 (-2.5A)
 0.64A 4fxsA-1lrtA:
46.8		 4fxsA-1lrtA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		7 / 9 ASP A 253
ASN A 282
ILE A 304
GLY A 305
CYH A 310
THR A 312
ASP A 343
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 ( 3.2A)
None
IMP  A 500 (-2.8A)
 0.39A 4fxsA-1zfjA:
57.0		 4fxsA-1zfjA:
55.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		7 / 9 ASP A 129
ASN A 158
ILE A 180
GLY A 181
CYH A 186
THR A 188
ASP A 219
 None
IMP  A1338 ( 4.3A)
None
None
IMP  A1338 (-2.5A)
None
IMP  A1338 (-2.7A)
 0.34A 4fxsA-2bznA:
41.3		 4fxsA-2bznA:
28.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 163
SER A 164
ASN A 191
ILE A 213
GLY A 214
THR A 221
ASP A 252
 None
None
IMP  A 801 ( 4.2A)
None
None
None
IMP  A 801 (-2.5A)
 0.54A 4fxsA-3khjA:
45.4		 4fxsA-3khjA:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 9 ASP B 288
SER B 289
SER B 290
GLY B 340
CYH B 345
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
 0.85A 4fxsA-4af0B:
51.3		 4fxsA-4af0B:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		6 / 9 SER B 289
SER B 290
ASN B 317
GLY B 340
CYH B 345
ASP B 378
 MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 (-2.5A)
 0.47A 4fxsA-4af0B:
51.3		 4fxsA-4af0B:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		9 / 9 ASP A 250
SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
CYH A 307
THR A 309
ASP A 340
 None
None
None
IMP  A 501 ( 4.4A)
None
None
IMP  A 501 (-4.9A)
None
IMP  A 501 (-2.3A)
 0.53A 4fxsA-4ix2A:
55.8		 4fxsA-4ix2A:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		7 / 9 SER A 245
ASN A 273
ILE A 295
GLY A 296
CYH A 301
THR A 303
ASP A 334
 None
IMP  A 500 ( 4.1A)
None
None
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
IMP  A 500 (-2.6A)
 0.31A 4fxsA-4mz1A:
57.6		 4fxsA-4mz1A:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		7 / 9 ASP A 247
ASN A 276
ILE A 298
GLY A 299
CYH A 304
THR A 306
ASP A 337
 None
IMP  A 501 ( 4.3A)
None
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
IMP  A 501 (-2.6A)
 0.30A 4fxsA-5ahmA:
57.4		 4fxsA-5ahmA:
52.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 9 ASN A 276
ILE A 298
GLY A 299
CYH A 304
THR A 306
ASP A 337
 IMP  A1468 ( 4.4A)
None
None
None
None
IMP  A1468 (-2.6A)
 0.94A 4fxsA-5ahnA:
47.3		 4fxsA-5ahnA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 9 ASP A 247
ASN A 276
ILE A 298
GLY A 299
THR A 306
ASP A 337
 None
IMP  A1468 ( 4.4A)
None
None
None
IMP  A1468 (-2.6A)
 0.51A 4fxsA-5ahnA:
47.3		 4fxsA-5ahnA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 9 ASP A 143
ASN A 173
GLY A 196
CYH A 201
THR A 203
ASP A 234
 AUN  A 401 (-3.5A)
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
IMP  A 400 (-2.6A)
 0.42A 4fxsA-5ou3A:
52.5		 4fxsA-5ou3A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		7 / 9 ASP A 251
ASN A 280
ILE A 302
GLY A 303
CYH A 308
THR A 310
ASP A 341
 None
IMP  A 500 ( 4.3A)
None
None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
IMP  A 500 (-2.6A)
 0.33A 4fxsA-5upyA:
55.2		 4fxsA-5upyA:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		7 / 9 ASP A 251
ASN A 280
ILE A 302
GLY A 303
CYH A 308
THR A 310
ASP A 341
 None
IMP  A 501 (-4.1A)
None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
IMP  A 501 (-2.4A)
 0.38A 4fxsA-5uuwA:
55.2		 4fxsA-5uuwA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 9 ASN A 275
ILE A 297
GLY A 298
CYH A 303
THR A 305
ASP A 336
 IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
IMP  A 500 (-2.4A)
 0.32A 4fxsA-5uzeA:
54.3		 4fxsA-5uzeA:
45.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 9 ASP A 246
ASN A 275
ILE A 297
GLY A 298
CYH A 303
THR A 305
 None
IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
 0.77A 4fxsA-5uzeA:
54.3		 4fxsA-5uzeA:
45.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB
(Escherichia
coli) 		4 / 5 ALA A  69
ILE A  51
LEU A  52
LYS A  53
 None
None
None
IMP  A3036 ( 4.6A)
 1.22A 4g19A-2pyuA:
undetectable		 4g19A-2pyuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 PRO A 373
SER A 364
SER A 305
ASP A  52
ILE A 306
 None
IMP  A 501 (-2.8A)
IMP  A 501 (-2.2A)
None
None
 1.45A 4ktvA-4ix2A:
undetectable
4ktvB-4ix2A:
undetectable		 4ktvA-4ix2A:
23.62
4ktvB-4ix2A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ASP A 264
ASP A 358
SER A 263
ALA A 334
 TRS  A 600 ( 3.1A)
IMP  A 801 (-2.5A)
TAD  A 901 (-2.7A)
None
 0.88A 4m48A-1lrtA:
undetectable		 4m48A-1lrtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 12 GLY A 357
GLY A 335
ILE A 300
ILE A  44
ALA A  46
 IMP  A 500 (-3.5A)
IMP  A 500 (-3.5A)
None
None
IMP  A 500 (-3.3A)
 1.11A 4qtuB-4mz1A:
undetectable		 4qtuB-4mz1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ALA A 281
ALA A 322
GLY A 254
GLY A 278
ASP A 340
 None
None
None
None
IMP  A 501 (-2.3A)
 1.11A 4qvwK-4ix2A:
undetectable
4qvwL-4ix2A:
undetectable		 4qvwK-4ix2A:
22.34
4qvwL-4ix2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ALA A 281
ALA A 322
GLY A 254
GLY A 278
ASP A 340
 None
None
None
None
IMP  A 501 (-2.3A)
 1.11A 4qvwY-4ix2A:
undetectable
4qvwZ-4ix2A:
undetectable		 4qvwY-4ix2A:
22.34
4qvwZ-4ix2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 9 ALA A 281
ALA A 322
GLY A 254
GLY A 278
ASP A 340
 None
None
None
None
IMP  A 501 (-2.3A)
 1.12A 4qwuY-4ix2A:
undetectable
4qwuZ-4ix2A:
undetectable		 4qwuY-4ix2A:
22.61
4qwuZ-4ix2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 278
ALA A 319
GLY A 251
GLY A 275
ASP A 337
 None
None
None
None
IMP  A 501 (-2.6A)
 1.14A 4qwuY-5ahmA:
undetectable
4qwuZ-5ahmA:
undetectable		 4qwuY-5ahmA:
19.07
4qwuZ-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.90A 4txnA-4fxsA:
undetectable		 4txnA-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.87A 4txnA-5uzeA:
undetectable		 4txnA-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.91A 4txnB-4fxsA:
undetectable		 4txnB-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.89A 4txnB-5uzeA:
undetectable		 4txnB-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.95A 4txnC-4fxsA:
undetectable		 4txnC-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.91A 4txnC-5uzeA:
undetectable		 4txnC-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.89A 4txnD-4fxsA:
undetectable		 4txnD-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.89A 4txnD-5uzeA:
undetectable		 4txnD-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 ILE A 272
MET A  45
MET A 357
ALA A 335
ASN A 275
 None
None
IMP  A 500 ( 3.8A)
None
IMP  A 500 (-4.0A)
 1.47A 4zo1X-5uzeA:
undetectable		 4zo1X-5uzeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Caldanaerobacter
subterraneus) 		4 / 4 ASP A 161
GLY A  46
ASP A 102
ASP A 105
 MG  A1192 ( 2.6A)
IMP  A1210 (-3.2A)
MG  A1191 (-2.8A)
IMP  A1210 (-4.2A)
 1.14A 5e72A-1yfzA:
undetectable		 5e72A-1yfzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		4 / 4 ASP A 200
GLY A  76
ASP A 141
ASP A 144
 None
None
IMP  A1300 (-2.4A)
IMP  A1300 (-4.3A)
 1.10A 5e72A-5ipfA:
undetectable		 5e72A-5ipfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 GLY A 314
GLY A 315
VAL A 293
ASP A 358
 TAD  A 901 (-3.9A)
None
None
IMP  A 801 (-2.5A)
 0.76A 5f8yA-1lrtA:
undetectable		 5f8yA-1lrtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 GLY A 314
GLY A 315
VAL A 293
ASP A 358
 TAD  A 901 (-3.9A)
None
None
IMP  A 801 (-2.5A)
 0.76A 5f8yB-1lrtA:
undetectable		 5f8yB-1lrtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A 295
VAL A 264
LEU A  40
ILE A  47
MET A 362
 None
None
None
None
IMP  A 501 ( 3.7A)
 1.19A 5hv1A-5uuwA:
2.1		 5hv1A-5uuwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 12 ILE A 274
GLY A 272
ASN A 273
ALA A 333
PHE A 327
 None
None
IMP  A 500 ( 4.1A)
None
None
 1.21A 5ih0A-4mz1A:
undetectable		 5ih0A-4mz1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 LEU B  84
ILE B 376
GLY B 379
ILE B 337
ALA B 360
 None
None
IMP  B1527 (-3.5A)
None
None
 1.34A 5j7wC-4af0B:
undetectable		 5j7wC-4af0B:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 432
LEU A 436
GLY A 360
ALA A 364
PHE A 363
 None
None
IMP  A 501 (-3.7A)
None
None
 1.04A 5mxbA-5ahmA:
undetectable		 5mxbA-5ahmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 LEU A 380
GLY A 360
GLY A 316
SER A  56
 None
IMP  A 801 (-4.1A)
IMP  A 801 (-3.6A)
None
 0.63A 5o96C-1lrtA:
undetectable		 5o96C-1lrtA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 11 LEU A 389
ILE A 367
GLY A 366
GLY A 328
LEU A 390
 None
None
IMP  A1331 (-3.7A)
IMP  A1331 ( 3.0A)
None
 0.92A 5twjD-1jr1A:
undetectable		 5twjD-1jr1A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB
(Escherichia
coli) 		4 / 5 ASP A 157
GLU A 175
ARG A 174
THR A 173
 IMP  A3036 (-2.9A)
None
None
None
 1.21A 5uxcA-2pyuA:
undetectable		 5uxcA-2pyuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A  51
GLY A 344
GLY A  70
LEU A  42
LEU A  44
 IMP  A 500 (-3.4A)
IMP  A 500 ( 3.7A)
None
None
None
 1.13A 5wwsA-1zfjA:
undetectable		 5wwsA-1zfjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ALA A  49
GLY A 342
GLY A  68
LEU A  40
LEU A  42
 IMP  A 500 (-3.4A)
IMP  A 500 ( 3.7A)
None
None
None
 1.08A 5wwsA-5upyA:
undetectable		 5wwsA-5upyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A  49
GLY A 342
GLY A  68
LEU A  40
LEU A  42
 IMP  A 501 (-3.2A)
IMP  A 501 (-3.1A)
None
None
None
 1.02A 5wwsA-5uuwA:
undetectable		 5wwsA-5uuwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 9 ASP A 341
ASN A 280
ILE A  54
GLY A  70
THR A  53
 IMP  A 500 (-2.6A)
IMP  A 500 ( 4.3A)
None
None
None
 1.42A 6awpA-5upyA:
undetectable		 6awpA-5upyA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 ASP A  71
ASP A 256
HIS A  93
SER A  68
GLY A 415
 None
None
None
IMP  A1331 (-2.6A)
IMP  A1331 ( 3.1A)
 1.16A 6b0lB-1jr1A:
3.0		 6b0lB-1jr1A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 ASP B  89
ASP B 270
HIS B 111
SER B  86
GLY B 429
 None
None
None
IMP  B1527 (-2.6A)
IMP  B1527 ( 3.3A)
 1.15A 6b0lB-4af0B:
undetectable		 6b0lB-4af0B:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 LEU A 273
VAL A 350
ARG A 322
VAL A 323
ASP A 364
 None
None
MOA  A1332 (-3.6A)
None
IMP  A1331 (-2.8A)
 1.39A 6bxlB-1jr1A:
undetectable		 6bxlB-1jr1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 LEU B 287
VAL B 364
ARG B 336
ILE B 337
ASP B 378
 None
None
MOA  B1526 (-3.6A)
None
IMP  B1527 (-2.5A)
 1.41A 6bxnA-4af0B:
undetectable		 6bxnA-4af0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ASP A 348
ALA A 357
GLY A 341
ARG A 344
VAL A 299
 None
None
IMP  A 501 ( 3.8A)
None
None
 1.27A 6clxA-4ix2A:
undetectable		 6clxA-4ix2A:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 345
ALA A 354
GLY A 338
ARG A 341
VAL A 296
 None
None
IMP  A 501 (-3.6A)
None
None
 1.29A 6clxA-5ahmA:
undetectable		 6clxA-5ahmA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 9 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.29A 6czmA-5ipfA:
undetectable
6czmB-5ipfA:
undetectable		 6czmA-5ipfA:
22.38
6czmB-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 9 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.27A 6czmD-5ipfA:
undetectable
6czmE-5ipfA:
undetectable		 6czmD-5ipfA:
22.38
6czmE-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 10 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.30A 6czmE-5ipfA:
undetectable
6czmF-5ipfA:
undetectable		 6czmE-5ipfA:
22.38
6czmF-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 ALA A 295
ASP A 253
ILE A 252
ILE A 250
 None
IMP  A 500 ( 4.7A)
None
None
 0.96A 6fbnA-1zfjA:
undetectable		 6fbnA-1zfjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2
(Cricetulus
griseus) 		5 / 12 GLY A 413
GLY A 415
GLY A 398
ASN A  94
ARG A 412
 IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
None
None
None
 1.07A 6gngB-1jr1A:
undetectable		 6gngB-1jr1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Campylobacter
jejuni) 		5 / 12 GLY A 383
GLY A 385
GLY A 368
ASN A  72
ARG A 382
 IMP  A 500 (-3.3A)
IMP  A 500 ( 3.3A)
None
None
None
 1.00A 6gngB-4mz1A:
undetectable		 6gngB-4mz1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 386
GLY A 388
GLY A 371
ASN A  73
ARG A 385
 IMP  A 501 (-3.1A)
IMP  A 501 (-3.1A)
None
None
None
 0.99A 6gngB-5ahmA:
undetectable		 6gngB-5ahmA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 283
GLY A 285
GLY A 268
ASN A  94
ARG A 282
 IMP  A 400 (-3.3A)
AUN  A 401 ( 3.2A)
None
None
None
 1.11A 6gngB-5ou3A:
undetectable		 6gngB-5ou3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 LEU B  84
ILE B 376
GLY B 379
ILE B 337
ALA B 360
 None
None
IMP  B1527 (-3.5A)
None
None
 1.34A 6qyaD-4af0B:
undetectable		 6qyaD-4af0B:
21.42