SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IMO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 PHE A  46
ILE A 145
TYR A 149
GLY A  84
 None
IMO  A1601 ( 4.6A)
None
None
 0.89A 11gsA-1p9bA:
undetectable		 11gsA-1p9bA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 4 GLY A  15
LYS A  16
GLY A  17
HIS A  41
 GDP  A 432 (-3.3A)
IMO  A 440 ( 2.9A)
GDP  A 432 (-3.6A)
GDP  A 432 (-3.6A)
 0.32A 1mf1A-1cg4A:
57.4		 1mf1A-1cg4A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 4 GLY A  28
LYS A  29
GLY A  30
HIS A  54
 GDP  A1603 (-3.4A)
IMO  A1601 ( 2.8A)
GDP  A1603 (-3.7A)
IMO  A1601 ( 3.7A)
 0.23A 1mf1A-1p9bA:
58.0		 1mf1A-1p9bA:
42.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 10 GLU A 128
GLY A 146
CYH A 148
LEU A 176
ILE A 123
 None
IMO  A1601 ( 4.9A)
None
None
None
 1.11A 3adsA-1p9bA:
undetectable		 3adsA-1p9bA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 GLN A 224
THR A 300
ASN A  38
 IMO  A 440 (-3.6A)
None
IMO  A 440 (-4.0A)
 0.72A 3v4tE-1cg4A:
0.0		 3v4tE-1cg4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 VAL A  72
LEU A  74
LEU A  54
ASN A  38
ILE A 133
 None
None
None
IMO  A 440 (-4.0A)
IMO  A 440 ( 4.4A)
 1.47A 4lzrA-1cg4A:
undetectable		 4lzrA-1cg4A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ASN A  38
GLY A 225
ILE A 265
GLY A 264
ARG A  32
 IMO  A 440 (-4.0A)
None
None
None
None
 1.19A 4obwC-1cg4A:
2.3		 4obwC-1cg4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 ILE A 133
GLN A 224
ILE A 230
ASP A 229
 IMO  A 440 ( 4.4A)
IMO  A 440 (-3.6A)
None
None
 1.00A 4w5tA-1cg4A:
0.0		 4w5tA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 ILE A 133
GLN A 224
ILE A 230
ASP A 229
 IMO  A 440 ( 4.4A)
IMO  A 440 (-3.6A)
None
None
 1.02A 4z4cA-1cg4A:
undetectable		 4z4cA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A  12
GLY A  35
GLY A 225
GLU A 221
VAL A  73
 IMO  A 440 (-2.7A)
None
None
None
None
 0.90A 5ehgC-1cg4A:
undetectable		 5ehgC-1cg4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 ASN A 232
SER A 249
SER A 248
 IMO  A1601 (-3.7A)
None
None
 0.64A 5gsnA-1p9bA:
undetectable		 5gsnA-1p9bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 SER A 258
PHE A 240
THR A 247
ALA A 231
GLY A  21
 None
None
IMO  A1601 (-3.7A)
IMO  A1601 (-4.2A)
None
 1.09A 5veuA-1p9bA:
0.0		 5veuA-1p9bA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 242
GLY A 241
VAL A 326
ASN A 232
ASN A 330
 None
None
None
IMO  A1601 (-3.7A)
None
 1.07A 6gngA-1p9bA:
undetectable		 6gngA-1p9bA:
21.83