SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IMH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 12 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.34A 1jdvE-3mb8A:
31.8
1jdvF-3mb8A:
32.5		 1jdvE-3mb8A:
30.00
1jdvF-3mb8A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.28A 1odiA-3mb8A:
25.1		 1odiA-3mb8A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.31A 1odiB-3mb8A:
34.6		 1odiB-3mb8A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.29A 1odiC-3mb8A:
34.9		 1odiC-3mb8A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.30A 1odiD-3mb8A:
34.8		 1odiD-3mb8A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.24A 1odiE-3mb8A:
34.9		 1odiE-3mb8A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.25A 1odiF-3mb8A:
34.7		 1odiF-3mb8A:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		4 / 8 ARG A  93
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.26A 1pk7B-3mb8A:
32.3		 1pk7B-3mb8A:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 10 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.43A 1z35A-3mb8A:
32.3		 1z35A-3mb8A:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 9 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.40A 1z37A-3mb8A:
32.4		 1z37A-3mb8A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.28A 2ac7A-3mb8A:
30.7
2ac7B-3mb8A:
30.7		 2ac7A-3mb8A:
28.22
2ac7B-3mb8A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.28A 2ac7A-3mb8A:
30.7
2ac7B-3mb8A:
30.7		 2ac7A-3mb8A:
28.22
2ac7B-3mb8A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		4 / 8 VAL A 192
ASP A 186
LEU A 207
GLY A 205
 None
IMH  A 280 (-4.2A)
None
None
 0.78A 3af0A-3mb8A:
undetectable		 3af0A-3mb8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 12 ILE A  71
ALA A 223
ASP A  29
PRO A  30
ALA A  31
 IMH  A 280 (-4.0A)
None
None
None
None
 0.87A 3jb1A-3mb8A:
undetectable		 3jb1A-3mb8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		4 / 5 LEU A 175
SER A 179
LEU A 214
PRO A 213
 None
None
None
IMH  A 280 (-4.1A)
 1.23A 3onnA-3mb8A:
2.7		 3onnA-3mb8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
GLY A  98
MET A 187
GLU A 188
ASP A 210
 PO4  A 281 ( 3.0A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
IMH  A 280 (-2.9A)
 1.00A 3uawA-3mb8A:
32.7		 3uawA-3mb8A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 11 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.27A 3uawA-3mb8A:
32.7		 3uawA-3mb8A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Toxoplasma
gondii) 		5 / 10 ARG A  93
THR A  96
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
PO4  A 281 ( 3.2A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.25A 3uayA-3mb8A:
32.4		 3uayA-3mb8A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3b9g IAG-NUCLEOSIDE
HYDROLASE
(Trypanosoma
vivax) 		5 / 11 ASP A 251
ALA A 252
TYR A 257
CYH A 135
VAL A 258
 IMH  A 501 ( 2.6A)
None
None
None
None
 1.40A 5c8tB-3b9gA:
1.6		 5c8tB-3b9gA:
22.28