SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IM5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		10 / 10 GLY A 118
PHE A 200
GLU A 201
VAL A 217
GLY A 218
MET A 219
THR A 242
ASN A 243
VAL A 245
HIS A 257
 IM5  A 308 (-3.7A)
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-4.3A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.6A)
 0.62A 1pwyE-5ugfA:
44.1		 1pwyE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 GLY A 218
PHE A 200
GLU A 201
GLY A 197
HIS A 257
 IM5  A 308 (-3.4A)
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
None
IM5  A 308 (-3.6A)
 1.15A 1pwyE-5ugfA:
44.1		 1pwyE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 GLY A 218
PHE A 200
GLY A 197
VAL A 217
HIS A 257
 IM5  A 308 (-3.4A)
IM5  A 308 (-4.6A)
None
IM5  A 308 (-4.4A)
IM5  A 308 (-3.6A)
 1.22A 1pwyE-5ugfA:
44.1		 1pwyE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 PHE A 200
GLU A 201
VAL A 245
GLY A 118
HIS A 257
 IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.7A)
IM5  A 308 (-3.6A)
 1.22A 1pwyE-5ugfA:
44.1		 1pwyE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		10 / 10 GLY A 118
PHE A 200
GLU A 201
VAL A 217
GLY A 218
MET A 219
THR A 242
ASN A 243
VAL A 245
HIS A 257
 IM5  A 308 (-3.7A)
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-4.3A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.6A)
 0.43A 1v3qE-5ugfA:
44.8		 1v3qE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 GLY A 119
GLU A 201
VAL A 217
ASN A 243
VAL A 245
 None
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.5A)
 1.32A 1v3qE-5ugfA:
44.8		 1v3qE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 GLY A 218
PHE A 200
GLU A 201
GLY A 197
HIS A 257
 IM5  A 308 (-3.4A)
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
None
IM5  A 308 (-3.6A)
 1.24A 1v3qE-5ugfA:
44.8		 1v3qE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 PHE A 200
GLU A 201
VAL A 245
GLY A 118
HIS A 257
 IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.7A)
IM5  A 308 (-3.6A)
 1.11A 1v3qE-5ugfA:
44.8		 1v3qE-5ugfA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 6 GLY A 118
GLU A 201
GLY A 218
MET A 219
ASN A 243
 IM5  A 308 (-3.7A)
IM5  A 308 (-2.9A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-3.1A)
 0.62A 3e9rA-5ugfA:
40.3		 3e9rA-5ugfA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 6 GLY A 118
GLU A 201
GLY A 218
MET A 219
ASN A 243
 IM5  A 308 (-3.7A)
IM5  A 308 (-2.9A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-3.1A)
 0.66A 3e9rC-5ugfA:
40.6		 3e9rC-5ugfA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		11 / 12 SER A  33
TYR A  88
ALA A 116
GLY A 118
GLU A 201
VAL A 217
GLY A 218
MET A 219
ASN A 243
HIS A 257
VAL A 260
 PO4  A 301 (-2.8A)
IM5  A 308 (-4.5A)
PO4  A 301 ( 4.0A)
IM5  A 308 (-3.7A)
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-3.1A)
IM5  A 308 (-3.6A)
IM5  A 308 ( 4.3A)
 0.41A 3f8wA-5ugfA:
42.2		 3f8wA-5ugfA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 HIS A  64
GLY A 118
ASN A 243
HIS A 257
VAL A 260
 PO4  A 301 (-4.5A)
IM5  A 308 (-3.7A)
IM5  A 308 (-3.1A)
IM5  A 308 (-3.6A)
IM5  A 308 ( 4.3A)
 1.15A 3f8wB-5ugfA:
43.7		 3f8wB-5ugfA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		11 / 12 SER A  33
HIS A  86
TYR A  88
GLY A 118
GLU A 201
VAL A 217
GLY A 218
MET A 219
ASN A 243
HIS A 257
VAL A 260
 PO4  A 301 (-2.8A)
PO4  A 301 (-4.0A)
IM5  A 308 (-4.5A)
IM5  A 308 (-3.7A)
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-3.1A)
IM5  A 308 (-3.6A)
IM5  A 308 ( 4.3A)
 0.40A 3f8wB-5ugfA:
43.7		 3f8wB-5ugfA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 TYR A  88
VAL A 217
GLY A 218
MET A 219
HIS A  64
 IM5  A 308 (-4.5A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
PO4  A 301 (-4.5A)
 1.41A 3f8wB-5ugfA:
43.7		 3f8wB-5ugfA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		11 / 12 SER A  33
HIS A  86
TYR A  88
ALA A 116
GLY A 118
GLU A 201
VAL A 217
GLY A 218
MET A 219
ASN A 243
VAL A 260
 PO4  A 301 (-2.8A)
PO4  A 301 (-4.0A)
IM5  A 308 (-4.5A)
PO4  A 301 ( 4.0A)
IM5  A 308 (-3.7A)
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.3A)
 0.36A 3f8wC-5ugfA:
42.0		 3f8wC-5ugfA:
44.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLY A  32
ASN A 243
VAL A 245
GLY A 218
SER A 220
 PO4  A 301 (-3.1A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.4A)
PO4  A 301 (-2.5A)
 1.26A 3k13B-5ugfA:
undetectable		 3k13B-5ugfA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 4 LEU A  35
GLY A  34
GLY A 264
THR A 242
 None
None
None
IM5  A 308 (-4.3A)
 0.79A 3si7A-5ugfA:
undetectable		 3si7A-5ugfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLU A  89
PRO A 198
GLU A 201
THR A 242
GLY A 118
 None
None
IM5  A 308 (-2.9A)
IM5  A 308 (-4.3A)
IM5  A 308 (-3.7A)
 1.12A 5xioA-5ugfA:
undetectable		 5xioA-5ugfA:
19.96