SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ILP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.14A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 141
ARG A 143
THR A 240
GLY A 312
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
ILP  A 400 (-3.5A)
 0.61A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.15A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
THR A 240
GLY A 312
THR A 313
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.64A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.34A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
THR A 313
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.77A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 TYR A 173
MET A 241
GLY A 312
THR A 313
ALA A 314
 None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 1.18A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 TYR A 173
THR A 240
MET A 241
GLY A 312
THR A 313
 None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 1.18A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.42A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
THR A 313
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.77A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 11 PHE A  75
TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 None
ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.42A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 11 PHE A  75
TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
THR A 313
 None
ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.74A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 9 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.47A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
 0.82A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.50A 2ej3A-1kt8A:
30.7		 2ej3A-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 10 PHE A  75
TYR A 141
ARG A 143
TYR A 207
GLY A 312
THR A 313
ALA A 314
 None
ILP  A 400 (-4.5A)
None
ILP  A 400 (-4.5A)
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.42A 2ej3B-1kt8A:
30.8		 2ej3B-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.52A 2ej3C-1kt8A:
30.5		 2ej3C-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A 242
GLY A 312
GLN A 316
LEU A  95
ILE A 265
 ILP  A 400 (-3.5A)
ILP  A 400 (-3.5A)
None
ACY  A1005 ( 4.8A)
None
 1.30A 3mneA-1kt8A:
undetectable		 3mneA-1kt8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 199
ILE A 265
ASN A 242
GLU A 237
 None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.4A)
 1.10A 4g0vA-1kt8A:
undetectable		 4g0vA-1kt8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 312
SER A 311
LEU A 349
GLU A  76
 ILP  A 400 (-3.5A)
None
None
None
 0.79A 5izfA-1kt8A:
undetectable		 5izfA-1kt8A:
22.57