SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IK2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 10 GLU A 241
ALA A 248
LEU A 357
GLU A 207
MET A 209
 None
None
None
IK2  A1435 (-4.0A)
None
 1.41A 1a29A-4aoaA:
undetectable		 1a29A-4aoaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		3 / 3 TYR A  46
TYR A  76
ILE A  73
 None
IK2  A1435 (-4.6A)
None
 0.64A 3eteA-4aoaA:
undetectable
3eteB-4aoaA:
undetectable		 3eteA-4aoaA:
22.04
3eteB-4aoaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		3 / 3 SER A 131
GLY A 132
THR A 133
 IK2  A1435 (-3.8A)
IK2  A1435 (-3.4A)
IK2  A1435 (-3.6A)
 0.15A 3k9wA-4aoaA:
undetectable		 3k9wA-4aoaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 10 ALA A 139
THR A 174
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.97A 4qvpK-4aoaA:
undetectable
4qvpL-4aoaA:
undetectable		 4qvpK-4aoaA:
17.19
4qvpL-4aoaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 10 ALA A 139
THR A 174
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.97A 4qvpY-4aoaA:
undetectable
4qvpZ-4aoaA:
undetectable		 4qvpY-4aoaA:
17.19
4qvpZ-4aoaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		4 / 5 ALA A  78
ARG A  41
HIS A  83
ALA A  74
 None
IK2  A1435 (-4.0A)
None
None
 1.21A 5a06C-4aoaA:
2.6
5a06D-4aoaA:
3.1		 5a06C-4aoaA:
23.99
5a06D-4aoaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 11 ALA A 135
ALA A 139
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.92A 6hwdK-4aoaA:
undetectable
6hwdL-4aoaA:
undetectable		 6hwdK-4aoaA:
10.96
6hwdL-4aoaA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE
(Variovorax
paradoxus) 		5 / 11 ALA A 135
ALA A 139
GLY A 162
GLY A 161
ASP A 240
 None
None
None
IK2  A1435 (-3.6A)
IK2  A1435 (-2.8A)
 0.93A 6hwdY-4aoaA:
undetectable
6hwdZ-4aoaA:
undetectable		 6hwdY-4aoaA:
10.96
6hwdZ-4aoaA:
11.71