SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'II6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KF6_N_ACTN803_0 (FUMARATE REDUCTASE FLAVOPROTEIN FUMARATE REDUCTASE IRON-SULFUR PROTEIN)	5all	SOLUBLE EPOXIDE HYDROLASE (Homo sapiens)	4 / 6	GLY A 266 ASP A 335 TYR A 296 TRP A 465	None II6 A1552 ( 3.0A) None None	1.34A	1kf6M-5allA: undetectable 1kf6N-5allA: undetectable	1kf6M-5allA: 22.80 1kf6N-5allA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PFG_A_SAMA264_0 (N-METHYLTRANSFERASE)	5all	SOLUBLE EPOXIDE HYDROLASE (Homo sapiens)	5 / 12	GLY A 337 LEU A 358 SER A 357 PHE A 267 HIS A 524	None None None None II6 A1552 (-3.6A)	1.39A	3pfgA-5allA: undetectable	3pfgA-5allA: 17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J03_A_FVSA603_1 (BIFUNCTIONAL EPOXIDE HYDROLASE 2)	5all	SOLUBLE EPOXIDE HYDROLASE (Homo sapiens)	12 / 12	ASP A 335 TYR A 343 ILE A 363 PHE A 381 TYR A 383 PHE A 387 LEU A 408 LEU A 428 TYR A 466 LEU A 499 HIS A 524 TRP A 525	II6 A1552 ( 3.0A) None None None II6 A1552 (-4.2A) None None None SO4 A1550 ( 4.8A) SO4 A1550 (-4.8A) II6 A1552 (-3.6A) II6 A1552 ( 4.7A)	0.44A	4j03A-5allA: 56.8	4j03A-5allA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_A_5OGA804_1 (HDAC6 PROTEIN)	5all	SOLUBLE EPOXIDE HYDROLASE (Homo sapiens)	5 / 12	SER A 273 HIS A 334 ASP A 496 HIS A 524 GLY A 523	None None None II6 A1552 (-3.6A) None	1.31A	5eenA-5allA: undetectable	5eenA-5allA: 21.98

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KF6_N_ACTN803_0","FUMARATE REDUCTASE FLAVOPROTEIN;FUMARATE REDUCTASE IRON-SULFUR PROTEIN","5all","SOLUBLE EPOXIDE HYDROLASE","Homo sapiens",4,"GLY A 266;ASP A 335;TYR A 296;TRP A 465","None;II6 A1552 ( 3.0A);None;None","1.34A","1kf6M-5allA:undetectable;1kf6N-5allA:undetectable",null],["3PFG_A_SAMA264_0","N-METHYLTRANSFERASE","5all","SOLUBLE EPOXIDE HYDROLASE","Homo sapiens",5,"GLY A 337;LEU A 358;SER A 357;PHE A 267;HIS A 524","None;None;None;None;II6 A1552 (-3.6A)","1.39A","3pfgA-5allA:undetectable","1kf6M-5allA:22.80;1kf6N-5allA:19.57"],["4J03_A_FVSA603_1","BIFUNCTIONAL EPOXIDE HYDROLASE 2","5all","SOLUBLE EPOXIDE HYDROLASE","Homo sapiens",12,"ASP A 335;TYR A 343;ILE A 363;PHE A 381;TYR A 383;PHE A 387;LEU A 408;LEU A 428;TYR A 466;LEU A 499;HIS A 524;TRP A 525","II6 A1552 ( 3.0A);None;None;None;II6 A1552 (-4.2A);None;None;None;SO4 A1550 ( 4.8A);SO4 A1550 (-4.8A);II6 A1552 (-3.6A);II6 A1552 ( 4.7A)","0.44A","4j03A-5allA:56.8","3pfgA-5allA:17.50"],["5EEN_A_5OGA804_1","HDAC6 PROTEIN","5all","SOLUBLE EPOXIDE HYDROLASE","Homo sapiens",5,"SER A 273;HIS A 334;ASP A 496;HIS A 524;GLY A 523","None;None;None;II6 A1552 (-3.6A);None","1.31A","5eenA-5allA:undetectable","4j03A-5allA:100.00"]]