SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IHZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.62A 1iepA-3dkoA:
31.0		 1iepA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 VAL A 695
ILE A 709
MET A 714
ARG A 757
 IHZ  A1001 ( 4.9A)
None
None
None
 0.73A 1iepA-3dkoA:
31.0		 1iepA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.79A 1iepB-3dkoA:
30.8		 1iepB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 7 LYS A 665
VAL A 695
ILE A 709
MET A 714
LEU A 765
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 (-4.6A)
 0.71A 1iepB-3dkoA:
30.8		 1iepB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
GLU A 682
MET A 686
VAL A 695
PHE A 713
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.73A 1opjA-3dkoA:
30.2		 1opjA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
VAL A 695
PHE A 713
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
 0.68A 1opjA-3dkoA:
30.2		 1opjA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
VAL A 695
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.82A 1opjB-3dkoA:
30.6		 1opjB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ILE A 639
VAL A 647
ALA A 663
GLU A 682
LEU A 749
HIS A 756
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
 0.88A 1uwjB-3dkoA:
7.8		 1uwjB-3dkoA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		9 / 12 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.56A 2gqgA-3dkoA:
31.3		 2gqgA-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.56A 2gqgB-3dkoA:
30.7		 2gqgB-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.82A 2hyyA-3dkoA:
31.3		 2hyyA-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.77A 2hyyB-3dkoA:
31.4		 2hyyB-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.66A 2hyyB-3dkoA:
31.4		 2hyyB-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
VAL A 695
PHE A 713
GLY A 717
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.74A 2hyyC-3dkoA:
31.5		 2hyyC-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
MET A 686
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.5A)
None
None
 0.72A 2hyyC-3dkoA:
31.5		 2hyyC-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
ILE A 709
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
None
IHZ  A1001 (-4.8A)
 0.81A 2hyyD-3dkoA:
31.3		 2hyyD-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
ILE A 709
PHE A 713
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.72A 2hyyD-3dkoA:
31.3		 2hyyD-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 GLY A 640
VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
GLY A 717
LEU A 765
 None
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.80A 2ityA-3dkoA:
31.7		 2ityA-3dkoA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.72A 2itzA-3dkoA:
31.3		 2itzA-3dkoA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.70A 2oiqA-3dkoA:
32.9		 2oiqA-3dkoA:
41.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
ILE A 709
GLY A 717
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.71A 2oiqA-3dkoA:
32.9		 2oiqA-3dkoA:
41.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		9 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.82A 2pl0A-3dkoA:
7.0		 2pl0A-3dkoA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ILE A 639
ALA A 663
LYS A 665
GLU A 682
MET A 686
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.57A 2y6oA-3dkoA:
37.6		 2y6oA-3dkoA:
75.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ILE A 639
VAL A 647
ALA A 663
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.64A 2y7jA-3dkoA:
22.9		 2y7jA-3dkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 10 ILE A 639
VAL A 647
ALA A 663
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.63A 2y7jB-3dkoA:
23.4		 2y7jB-3dkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 10 ILE A 639
VAL A 647
ALA A 663
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.66A 2y7jC-3dkoA:
22.9		 2y7jC-3dkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 10 ILE A 639
VAL A 647
ALA A 663
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.61A 2y7jD-3dkoA:
23.2		 2y7jD-3dkoA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		9 / 12 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.68A 2zvaA-3dkoA:
32.1		 2zvaA-3dkoA:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 10 VAL A 647
LYS A 665
VAL A 695
ILE A 709
PHE A 713
VAL A 774
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 4.7A)
IHZ  A1001 (-4.8A)
 0.55A 3cs9A-3dkoA:
31.4		 3cs9A-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
GLU A 682
MET A 686
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.73A 3cs9B-3dkoA:
32.4		 3cs9B-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 12 ALA A 663
GLY A 717
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.68A 3cs9B-3dkoA:
32.4		 3cs9B-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 9 VAL A 647
LYS A 665
VAL A 695
ILE A 709
LEU A 765
VAL A 774
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 ( 4.7A)
 0.65A 3cs9B-3dkoA:
32.4		 3cs9B-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
GLU A 682
MET A 686
PHE A 713
HIS A 756
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
 0.74A 3cs9C-3dkoA:
31.4		 3cs9C-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 9 VAL A 647
LYS A 665
VAL A 695
ILE A 709
MET A 714
VAL A 774
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 4.7A)
IHZ  A1001 (-4.7A)
 0.76A 3cs9C-3dkoA:
31.4		 3cs9C-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 VAL A 647
LYS A 665
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.76A 3cs9D-3dkoA:
27.9		 3cs9D-3dkoA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
MET A 686
VAL A 695
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.75A 3ik3A-3dkoA:
31.1		 3ik3A-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
MET A 686
VAL A 695
ILE A 711
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.85A 3ik3A-3dkoA:
31.1		 3ik3A-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
VAL A 695
ILE A 711
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.73A 3ik3A-3dkoA:
31.1		 3ik3A-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
MET A 686
VAL A 695
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.76A 3ik3B-3dkoA:
30.9		 3ik3B-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
VAL A 695
ILE A 711
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.86A 3ik3B-3dkoA:
30.9		 3ik3B-3dkoA:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ALA A 663
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.81A 3k54A-3dkoA:
31.5		 3k54A-3dkoA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 3k54A-3dkoA:
31.5		 3k54A-3dkoA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.76A 3k5vA-3dkoA:
30.5		 3k5vA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.61A 3k5vA-3dkoA:
30.5		 3k5vA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.77A 3k5vB-3dkoA:
30.4		 3k5vB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 11 ILE A 639
ALA A 663
VAL A 695
PHE A 713
MET A 714
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.80A 3miyA-3dkoA:
33.0		 3miyA-3dkoA:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 9 ILE A 639
ALA A 663
PHE A 713
MET A 714
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.78A 3miyB-3dkoA:
32.8		 3miyB-3dkoA:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.79A 3ms9A-3dkoA:
27.6		 3ms9A-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.57A 3ms9A-3dkoA:
27.6		 3ms9A-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 VAL A 695
ILE A 709
MET A 714
ARG A 757
 IHZ  A1001 ( 4.9A)
None
None
None
 0.90A 3ms9A-3dkoA:
27.6		 3ms9A-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 7 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.63A 3ms9B-3dkoA:
27.7		 3ms9B-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.77A 3mssA-3dkoA:
30.8		 3mssA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.60A 3mssA-3dkoA:
30.8		 3mssA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 VAL A 695
ILE A 709
MET A 714
ARG A 757
 IHZ  A1001 ( 4.9A)
None
None
None
 0.88A 3mssA-3dkoA:
30.8		 3mssA-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 7 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.64A 3mssB-3dkoA:
30.9		 3mssB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 7 VAL A 695
ILE A 709
MET A 714
ARG A 757
 IHZ  A1001 ( 4.9A)
None
None
None
 0.75A 3mssB-3dkoA:
30.9		 3mssB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.77A 3mssC-3dkoA:
30.7		 3mssC-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.66A 3mssC-3dkoA:
30.7		 3mssC-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 6 VAL A 695
ILE A 709
MET A 714
ARG A 757
 IHZ  A1001 ( 4.9A)
None
None
None
 0.89A 3mssC-3dkoA:
30.7		 3mssC-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 6 VAL A 647
LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.64A 3mssD-3dkoA:
30.9		 3mssD-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.80A 3oezB-3dkoA:
33.1		 3oezB-3dkoA:
41.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
MET A 686
VAL A 695
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.74A 3oxzA-3dkoA:
30.9		 3oxzA-3dkoA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
MET A 686
VAL A 695
GLY A 717
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.77A 3oxzA-3dkoA:
30.9		 3oxzA-3dkoA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 9 ILE A 709
MET A 714
ARG A 757
LEU A 765
VAL A 774
 None
None
None
IHZ  A1001 (-4.6A)
IHZ  A1001 ( 4.7A)
 0.70A 3oxzA-3dkoA:
30.9		 3oxzA-3dkoA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 9 LYS A 665
ILE A 709
MET A 714
LEU A 765
VAL A 774
 IHZ  A1001 ( 4.5A)
None
None
IHZ  A1001 (-4.6A)
IHZ  A1001 ( 4.7A)
 0.56A 3oxzA-3dkoA:
30.9		 3oxzA-3dkoA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.73A 3pyyA-3dkoA:
31.7		 3pyyA-3dkoA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 VAL A 647
ALA A 663
PHE A 713
GLY A 717
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.93A 3pyyA-3dkoA:
31.7		 3pyyA-3dkoA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.75A 3qlgA-3dkoA:
32.6		 3qlgA-3dkoA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 7 LYS A 665
VAL A 694
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.52A 3rgfA-3dkoA:
undetectable		 3rgfA-3dkoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 9 ILE A 639
ALA A 663
VAL A 695
PHE A 713
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
 0.68A 3ti1A-3dkoA:
21.6		 3ti1A-3dkoA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ALA A 663
LYS A 665
VAL A 695
ILE A 709
PHE A 713
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.36A 3ue4A-3dkoA:
31.7		 3ue4A-3dkoA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
MET A 686
VAL A 695
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.60A 3ue4B-3dkoA:
31.9		 3ue4B-3dkoA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 5 LYS A 665
ILE A 685
VAL A 695
LEU A 765
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
 0.59A 3wzdA-3dkoA:
32.0		 3wzdA-3dkoA:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 8 VAL A 694
VAL A 695
LEU A 765
ASP A 776
PHE A 777
 None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.42A 3wzeA-3dkoA:
32.6		 3wzeA-3dkoA:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
LEU A 749
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.77A 3zosB-3dkoA:
30.3		 3zosB-3dkoA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 11 ALA A 663
VAL A 695
PHE A 713
GLY A 717
LEU A 765
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.7A)
 0.61A 4agdA-3dkoA:
31.1		 4agdA-3dkoA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
GLU A 682
ILE A 685
MET A 686
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 (-3.5A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.98A 4bkjB-3dkoA:
30.3		 4bkjB-3dkoA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
ILE A 685
MET A 686
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 (-3.5A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 1.00A 4bkjB-3dkoA:
30.3		 4bkjB-3dkoA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
ILE A 709
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.69A 4c8bA-3dkoA:
26.9		 4c8bA-3dkoA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
LYS A 665
GLU A 682
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.83A 4c8bB-3dkoA:
27.0		 4c8bB-3dkoA:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
GLU A 682
ILE A 685
MET A 686
VAL A 695
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.77A 4csvA-3dkoA:
28.6		 4csvA-3dkoA:
41.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
GLU A 682
ILE A 685
VAL A 695
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.81A 4csvA-3dkoA:
28.6		 4csvA-3dkoA:
41.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 10 ILE A 639
ALA A 663
VAL A 695
PHE A 713
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.83A 4ks8A-3dkoA:
23.2		 4ks8A-3dkoA:
29.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
 0.56A 4mxoA-3dkoA:
32.7		 4mxoA-3dkoA:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.48A 4mxoB-3dkoA:
32.7		 4mxoB-3dkoA:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 4mxxA-3dkoA:
32.3		 4mxxA-3dkoA:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
VAL A 695
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.56A 4mxxB-3dkoA:
32.0		 4mxxB-3dkoA:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 4mxyA-3dkoA:
32.2		 4mxyA-3dkoA:
41.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 4mxzA-3dkoA:
32.2		 4mxzA-3dkoA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ILE A 639
ALA A 663
LYS A 665
GLU A 682
ILE A 709
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 (-4.6A)
 0.81A 4qmnA-3dkoA:
25.5		 4qmnA-3dkoA:
26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 12 ALA A 663
GLU A 682
MET A 686
LEU A 749
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.7A)
 0.80A 4qrcA-3dkoA:
31.7		 4qrcA-3dkoA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
PHE A 713
MET A 714
GLY A 717
ASN A 763
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
 0.76A 4twpA-3dkoA:
30.3		 4twpA-3dkoA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
PHE A 713
MET A 714
GLY A 717
ASN A 763
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
 0.77A 4twpB-3dkoA:
30.8		 4twpB-3dkoA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
MET A 686
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.68A 4tyjA-3dkoA:
32.8		 4tyjA-3dkoA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
GLY A 717
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.47A 4u0iA-3dkoA:
32.7		 4u0iA-3dkoA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
GLU A 682
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.68A 4uxqA-3dkoA:
32.6		 4uxqA-3dkoA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
LEU A 749
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.50A 4uxqA-3dkoA:
32.6		 4uxqA-3dkoA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
MET A 686
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.70A 4v01A-3dkoA:
32.1		 4v01A-3dkoA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ALA A 663
GLU A 682
MET A 686
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.75A 4v01B-3dkoA:
32.4		 4v01B-3dkoA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
GLU A 682
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.70A 4v04B-3dkoA:
31.9		 4v04B-3dkoA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 11 ALA A 663
LYS A 665
MET A 714
GLY A 717
ASN A 763
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
 0.92A 4wa9A-3dkoA:
27.7		 4wa9A-3dkoA:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
PHE A 713
MET A 714
GLY A 717
ASN A 763
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
 0.92A 4wa9B-3dkoA:
30.7		 4wa9B-3dkoA:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.5A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.86A 4xeyA-3dkoA:
31.5		 4xeyA-3dkoA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
VAL A 695
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.64A 4xeyA-3dkoA:
31.5		 4xeyA-3dkoA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
VAL A 695
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.50A 4xeyB-3dkoA:
31.0		 4xeyB-3dkoA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.67A 4xliA-3dkoA:
31.5		 4xliA-3dkoA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.54A 4xliB-3dkoA:
26.1		 4xliB-3dkoA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ILE A 639
ALA A 663
LYS A 665
GLU A 682
ILE A 709
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.76A 5i9xA-3dkoA:
35.7		 5i9xA-3dkoA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ILE A 639
ALA A 663
LYS A 665
GLU A 682
MET A 686
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.58A 5i9yA-3dkoA:
36.5		 5i9yA-3dkoA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ILE A 639
GLY A 640
VAL A 647
ALA A 663
LYS A 665
GLU A 682
GLY A 717
 IHZ  A1001 ( 4.8A)
None
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 3.9A)
 0.77A 5mafA-3dkoA:
23.1		 5mafA-3dkoA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 10 VAL A 647
LYS A 665
GLU A 682
ILE A 709
PHE A 713
MET A 714
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
None
None
IHZ  A1001 (-4.7A)
 0.77A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 10 VAL A 647
LYS A 665
ILE A 709
PHE A 713
MET A 714
GLY A 717
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
None
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.7A)
 0.71A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 12 ALA A 663
MET A 686
VAL A 695
HIS A 756
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
 0.67A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		6 / 12 ALA A 663
VAL A 695
ILE A 711
HIS A 756
LEU A 765
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.73A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 4 VAL A 647
LYS A 665
VAL A 695
ASN A 763
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
 1.03A 5vc3A-3dkoA:
22.4		 5vc3A-3dkoA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		9 / 12 ILE A 639
VAL A 647
ALA A 663
GLU A 682
MET A 686
ILE A 709
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.78A 6fnmA-3dkoA:
37.0		 6fnmA-3dkoA:
70.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 ILE A 639
VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
ILE A 709
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
 0.77A 6fnmA-3dkoA:
37.0		 6fnmA-3dkoA:
70.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 ILE A 639
VAL A 647
ALA A 663
MET A 686
ILE A 709
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.94A 6fnmA-3dkoA:
37.0		 6fnmA-3dkoA:
70.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.73A 6hd4A-3dkoA:
30.4		 6hd4A-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
VAL A 695
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.70A 6hd4A-3dkoA:
30.4		 6hd4A-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.77A 6hd4B-3dkoA:
30.3		 6hd4B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
VAL A 695
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.72A 6hd4B-3dkoA:
30.3		 6hd4B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		9 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 (-4.8A)
 0.71A 6hd6A-3dkoA:
30.4		 6hd6A-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		9 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
VAL A 695
ILE A 709
PHE A 713
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.73A 6hd6A-3dkoA:
30.4		 6hd6A-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		8 / 12 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.74A 6hd6B-3dkoA:
30.3		 6hd6B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		7 / 12 VAL A 647
ALA A 663
LYS A 665
VAL A 695
PHE A 713
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.75A 6hd6B-3dkoA:
30.3		 6hd6B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		4 / 7 ILE A 709
MET A 714
GLY A 717
ARG A 757
 None
None
IHZ  A1001 ( 3.9A)
None
 0.89A 6hd6B-3dkoA:
30.3		 6hd6B-3dkoA:
13.26