SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IGP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_A_AG2A7005_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	3t44	INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (Mycobacterium tuberculosis)	4 / 6	LEU A 140 ASP A 120 ILE A 10 GLU A 168	None None None IGP A 300 (-3.0A)	1.10A	1mt1A-3t44A: undetectable 1mt1F-3t44A: undetectable	1mt1A-3t44A: 14.86 1mt1F-3t44A: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I9J_B_NCAB302_0 (ADP-RIBOSYL CYCLASE)	3t44	INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (Mycobacterium tuberculosis)	4 / 6	LEU A 240 GLU A 219 ASN A 189 SER A 90	IGP A 300 (-4.3A) IGP A 300 (-3.9A) IGP A 300 (-3.6A) None	1.42A	3i9jB-3t44A: undetectable	3i9jB-3t44A: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z84_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3t44	INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (Mycobacterium tuberculosis)	4 / 5	ILE A 142 PHE A 121 ARG A 191 THR A 195	None IGP A 300 (-4.3A) BE2 A 273 (-4.5A) None	1.23A	5z84N-3t44A: undetectable 5z84W-3t44A: undetectable	5z84N-3t44A: 19.69 5z84W-3t44A: 12.55

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MT1_A_AG2A7005_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","3t44","INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE","Mycobacterium tuberculosis",4,"LEU A 140;ASP A 120;ILE A  10;GLU A 168","None;None;None;IGP A 300 (-3.0A)","1.10A","1mt1A-3t44A:undetectable;1mt1F-3t44A:undetectable",null],["3I9J_B_NCAB302_0","ADP-RIBOSYL CYCLASE","3t44","INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE","Mycobacterium tuberculosis",4,"LEU A 240;GLU A 219;ASN A 189;SER A  90","IGP A 300 (-4.3A);IGP A 300 (-3.9A);IGP A 300 (-3.6A);None","1.42A","3i9jB-3t44A:undetectable","1mt1A-3t44A:14.86;1mt1F-3t44A:20.82"],["5Z84_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3t44","INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE","Mycobacterium tuberculosis",4,"ILE A 142;PHE A 121;ARG A 191;THR A 195","None;IGP A 300 (-4.3A);BE2 A 273 (-4.5A);None","1.23A","5z84N-3t44A:undetectable;5z84W-3t44A:undetectable","3i9jB-3t44A:21.55"]]