SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IFL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 10 ALA A 248
ASP A 249
ASP A 245
ILE A 244
PHE A 297
 None
IFL  A 504 (-2.8A)
None
None
None
 1.18A 1d4sA-4ayrA:
undetectable		 1d4sA-4ayrA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 12 ALA A  47
TRP A 424
GLN A 428
GLU A 452
ASN A 454
 None
None
None
IFL  A 503 (-3.1A)
NA  A 502 (-3.1A)
 1.44A 1lf9A-4ayrA:
15.4		 1lf9A-4ayrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 12 ALA A  47
TRP A 424
GLN A 428
GLU A 452
ASN A 454
 None
None
None
IFL  A 503 (-3.1A)
NA  A 502 (-3.1A)
 1.46A 1lf9B-4ayrA:
14.9		 1lf9B-4ayrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 12 GLY A 194
MET A 213
LEU A 255
THR A 451
ILE A 124
 None
None
None
IFL  A 503 ( 3.0A)
None
 1.30A 3mnpA-4ayrA:
undetectable		 3mnpA-4ayrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 ALA A  83
TRP A  47
GLY A 399
PRO A 401
 None
None
None
IFL  A1432 (-4.6A)
 0.92A 3ny4A-1uz4A:
undetectable		 3ny4A-1uz4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		4 / 8 ASN A 182
SER A 308
GLU A 365
GLU A 427
 IFL  A 504 (-3.5A)
None
IFL  A 503 (-3.0A)
IFL  A 503 (-2.9A)
 1.07A 3sg9B-4ayrA:
undetectable		 3sg9B-4ayrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		4 / 6 ARG A 356
LEU A 310
GLU A 346
SER A 347
 None
IFL  A 503 ( 4.7A)
None
None
 1.06A 3vlnA-4ayrA:
3.2		 3vlnA-4ayrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 11 GLN A 320
ASP A 249
ASP A 368
GLU A 365
ARG A 125
 CA  A 501 ( 4.2A)
IFL  A 504 (-2.8A)
CA  A 501 ( 4.8A)
IFL  A 503 (-3.0A)
IFL  A 503 ( 4.1A)
 1.29A 4fewA-4ayrA:
0.4
4fewD-4ayrA:
0.0		 4fewA-4ayrA:
21.22
4fewD-4ayrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		4 / 8 LEU A 362
GLY A 361
GLU A 365
ALA A 312
 None
None
IFL  A 503 (-3.0A)
None
 0.88A 4rjdA-4ayrA:
undetectable
4rjdB-4ayrA:
undetectable		 4rjdA-4ayrA:
11.48
4rjdB-4ayrA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		3 / 3 GLU A 452
ARG A 125
GLN A 428
 IFL  A 503 (-3.1A)
IFL  A 503 ( 4.1A)
None
 0.91A 4rtbA-4ayrA:
undetectable		 4rtbA-4ayrA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		3 / 3 GLU A 253
TYR A 431
GLU A 427
 CA  A 501 (-3.4A)
None
IFL  A 503 (-2.9A)
 0.75A 4ryaA-4ayrA:
undetectable		 4ryaA-4ayrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		4 / 6 PHE A  72
ARG A 125
GLU A  60
GLU A 427
 None
IFL  A 503 ( 4.1A)
None
IFL  A 503 (-2.9A)
 1.41A 5h4dA-4ayrA:
undetectable		 5h4dA-4ayrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 10 ASP A 249
ASP A 245
GLU A 452
GLU A 121
GLU A 309
 IFL  A 504 (-2.8A)
None
IFL  A 503 (-3.1A)
IFL  A 504 ( 4.4A)
None
 1.41A 5iqgA-4ayrA:
0.8		 5iqgA-4ayrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 10 ASP A 245
GLU A 452
GLU A 121
GLU A 427
GLU A 309
 None
IFL  A 503 (-3.1A)
IFL  A 504 ( 4.4A)
IFL  A 503 (-2.9A)
None
 1.46A 5iqgC-4ayrA:
0.0		 5iqgC-4ayrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Caulobacter
sp.
K31) 		5 / 10 ASP A 249
ASP A 245
GLU A 452
GLU A 121
GLU A 309
 IFL  A 504 (-2.8A)
None
IFL  A 503 (-3.1A)
IFL  A 504 ( 4.4A)
None
 1.36A 5iqgC-4ayrA:
0.0		 5iqgC-4ayrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 GLY A 382
GLN A 403
ASP A 400
ASP A 415
 None
IFL  A1432 ( 3.6A)
None
None
 1.13A 5vlmE-1uz4A:
undetectable		 5vlmE-1uz4A:
16.18