SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IFG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 1jffB-1nowA:
undetectable		 1jffB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 2hxfB-1nowA:
undetectable		 2hxfB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 2hxhB-1nowA:
undetectable		 2hxhB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		4 / 6 PRO A 215
HIS A 212
ASP A 240
TYR A 213
 None
None
IFG  A 557 ( 4.7A)
None
 1.38A 2lh8A-1nowA:
0.0		 2lh8A-1nowA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 2p4nB-1nowA:
undetectable		 2p4nB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 2wbeB-1nowA:
undetectable		 2wbeB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		4 / 5 HIS A 237
ASP A 290
HIS A 294
ASP A 354
 None
None
IFG  A 557 ( 4.3A)
IFG  A 557 (-3.6A)
 1.19A 3c0zA-1nowA:
2.3		 3c0zA-1nowA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 3dcoB-1nowA:
undetectable		 3dcoB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.15A 3edlB-1nowA:
undetectable		 3edlB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 ASP A 354
TYR A 450
ASP A 452
TRP A 489
GLY A 490
 IFG  A 557 (-3.6A)
IFG  A 557 (-4.6A)
IFG  A 557 (-3.2A)
IFG  A 557 (-3.6A)
None
 1.38A 3hiiA-1nowA:
undetectable		 3hiiA-1nowA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.15A 3iz0B-1nowA:
undetectable		 3iz0B-1nowA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		12 / 12 ARG A 211
HIS A 237
ASP A 240
ASP A 290
HIS A 294
ASP A 354
TRP A 424
TYR A 450
ASP A 452
LEU A 453
TRP A 489
GLU A 491
 IFG  A 557 (-2.8A)
None
IFG  A 557 ( 4.7A)
None
IFG  A 557 ( 4.3A)
IFG  A 557 (-3.6A)
IFG  A 557 (-3.6A)
IFG  A 557 (-4.6A)
IFG  A 557 (-3.2A)
None
IFG  A 557 (-3.6A)
IFG  A 557 (-3.2A)
 0.32A 3lmyA-1nowA:
62.9		 3lmyA-1nowA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		12 / 12 ARG A 211
HIS A 237
ASP A 240
ASP A 290
HIS A 294
ASP A 354
GLU A 355
TRP A 405
TRP A 424
TYR A 450
TRP A 489
GLU A 491
 IFG  A 557 (-2.8A)
None
IFG  A 557 ( 4.7A)
None
IFG  A 557 ( 4.3A)
IFG  A 557 (-3.6A)
IFG  A 557 (-3.1A)
IFG  A 557 (-3.3A)
IFG  A 557 (-3.6A)
IFG  A 557 (-4.6A)
IFG  A 557 (-3.6A)
IFG  A 557 (-3.2A)
 0.34A 3lmyB-1nowA:
62.6		 3lmyB-1nowA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 HIS A 237
ASP A 240
GLU A 491
TYR A 450
TRP A 489
 None
IFG  A 557 ( 4.7A)
IFG  A 557 (-3.2A)
IFG  A 557 (-4.6A)
IFG  A 557 (-3.6A)
 1.39A 3lmyB-1nowA:
62.6		 3lmyB-1nowA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		4 / 6 GLY A 352
GLU A 288
ASP A 208
GLU A 491
 None
None
None
IFG  A 557 (-3.2A)
 1.06A 3vywC-1nowA:
undetectable		 3vywC-1nowA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		4 / 6 GLU A 357
ASP A 354
ASP A 290
ARG A 211
 None
IFG  A 557 (-3.6A)
None
IFG  A 557 (-2.8A)
 1.15A 4ntxA-1nowA:
0.0
4ntxC-1nowA:
undetectable		 4ntxA-1nowA:
21.20
4ntxC-1nowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.14A 5ogcB-1nowA:
2.1		 5ogcB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		4 / 4 ASP A 208
SER A 210
ASP A 240
HIS A 294
 None
None
IFG  A 557 ( 4.7A)
IFG  A 557 ( 4.3A)
 1.36A 5wyqB-1nowA:
0.3		 5wyqB-1nowA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		5 / 10 ASP A 354
TRP A 405
GLY A 353
ASP A 317
THR A 295
 IFG  A 557 (-3.6A)
IFG  A 557 (-3.3A)
None
None
None
 1.33A 6mn1A-1nowA:
0.0		 6mn1A-1nowA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens) 		4 / 4 GLU A 288
ASP A 208
ARG A 211
TRP A 489
 None
None
IFG  A 557 (-2.8A)
IFG  A 557 (-3.6A)
 1.14A 6mn8A-1nowA:
0.0		 6mn8A-1nowA:
20.70