SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IFA'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 8 LEU A  17
LEU A 110
SER A 117
THR A 119
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.32A 1dvtA-3fc8A:
24.1
1dvtB-3fc8A:
23.0
1dvtA-3fc8A:
99.19
1dvtB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 8 LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.76A 1dvtA-3fc8A:
24.1
1dvtB-3fc8A:
23.0
1dvtA-3fc8A:
99.19
1dvtB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 7 LEU A  17
LEU A 110
SER A 115
SER A 117
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
None
IFA  A3000 (-3.9A)
0.82A 1dvxA-3fc8A:
24.2
1dvxA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 115
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
IFA  A3000 ( 4.9A)
0.80A 1dvxA-3fc8A:
24.2
1dvxA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
0.69A 1dvxB-3fc8A:
23.1
1dvxB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETA_1_T441128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 5 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.70A 1eta1-3fc8A:
22.5
1eta1-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETA_2_T442129_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 5 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.70A 1eta2-3fc8A:
21.3
1eta2-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETB_1_T441128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.72A 1etb1-3fc8A:
23.3
1etb1-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETB_2_T442129_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.67A 1etb2-3fc8A:
22.3
1etb2-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
1.20A 1f86A-3fc8A:
24.3
1f86A-3fc8A:
99.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.78A 1f86B-3fc8A:
23.0
1f86B-3fc8A:
99.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ICT_C_T44C128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
7 / 11 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
THR A 119
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
0.72A 1ictA-3fc8A:
22.9
1ictC-3fc8A:
22.9
1ictA-3fc8A:
100.00
1ictC-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ICT_D_T44D129_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.66A 1ictB-3fc8A:
22.7
1ictB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ICT_D_T44D129_2
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LEU A  17
THR A 106
LEU A 110
THR A 119
VAL A 121
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
0.49A 1ictD-3fc8A:
22.7
1ictD-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IE4_A_T44A128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 10 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.62A 1ie4A-3fc8A:
22.6
1ie4C-3fc8A:
22.6
1ie4A-3fc8A:
83.87
1ie4C-3fc8A:
83.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IE4_A_T44A128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 10 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.76A 1ie4A-3fc8A:
22.6
1ie4C-3fc8A:
22.6
1ie4A-3fc8A:
83.87
1ie4C-3fc8A:
83.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 8 LYS A  15
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.67A 1ie4B-3fc8A:
22.3
1ie4D-3fc8A:
22.3
1ie4B-3fc8A:
83.87
1ie4D-3fc8A:
83.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 8 LYS A  15
GLU A  54
ALA A 108
THR A 119
IFA  A3000 (-3.0A)
None
IFA  A3000 (-3.1A)
IFA  A3000 ( 4.9A)
0.76A 1ie4B-3fc8A:
22.3
1ie4D-3fc8A:
22.3
1ie4B-3fc8A:
83.87
1ie4D-3fc8A:
83.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_C_T3C601_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 6 GLU A  54
ALA A 108
LEU A 110
VAL A 121
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.62A 1sn5A-3fc8A:
20.7
1sn5A-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_C_T3C601_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 6 LEU A  17
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.53A 1sn5A-3fc8A:
20.7
1sn5A-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_C_T3C601_2
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 8 LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.68A 1sn5C-3fc8A:
20.5
1sn5C-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_C_T3C601_2
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 8 LYS A  15
LEU A  17
GLU A  54
THR A 106
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-4.1A)
1.05A 1sn5C-3fc8A:
20.5
1sn5C-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_D_T3D602_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 12 LEU A  17
GLU A  54
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.67A 1sn5B-3fc8A:
20.9
1sn5D-3fc8A:
21.0
1sn5B-3fc8A:
55.12
1sn5D-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_D_T3D602_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 12 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.93A 1sn5B-3fc8A:
20.9
1sn5D-3fc8A:
21.0
1sn5B-3fc8A:
55.12
1sn5D-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SN5_D_T3D602_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 12 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.97A 1sn5B-3fc8A:
20.9
1sn5D-3fc8A:
21.0
1sn5B-3fc8A:
55.12
1sn5D-3fc8A:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TT6_A_DESA129_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.63A 1tt6A-3fc8A:
23.3
1tt6A-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TT6_B_DESB128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.58A 1tt6B-3fc8A:
24.6
1tt6B-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.74A 1tyrA-3fc8A:
22.4
1tyrA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 6 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.98A 1tyrA-3fc8A:
22.4
1tyrA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 7 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.71A 1tyrB-3fc8A:
21.5
1tyrB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 7 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.48A 1tyrB-3fc8A:
21.5
1tyrB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 11 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.74A 1tz8A-3fc8A:
23.3
1tz8B-3fc8A:
23.5
1tz8A-3fc8A:
100.00
1tz8B-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 11 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.73A 1tz8A-3fc8A:
23.3
1tz8B-3fc8A:
23.5
1tz8A-3fc8A:
100.00
1tz8B-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.69A 1tz8C-3fc8A:
23.3
1tz8D-3fc8A:
23.8
1tz8C-3fc8A:
100.00
1tz8D-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.97A 1tz8D-3fc8A:
23.8
1tz8D-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ROX_A_T44A128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
0.81A 2roxA-3fc8A:
23.2
2roxA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ROX_B_T44B128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.70A 2roxB-3fc8A:
22.2
2roxB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.76A 3cfqA-3fc8A:
24.0
3cfqA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.88A 3cfqA-3fc8A:
24.0
3cfqA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.70A 3cfqA-3fc8A:
24.0
3cfqB-3fc8A:
23.0
3cfqA-3fc8A:
100.00
3cfqB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.48A 3cfqA-3fc8A:
24.0
3cfqB-3fc8A:
23.0
3cfqA-3fc8A:
100.00
3cfqB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
ALA A 108
LEU A 110
SER A 117
THR A 119
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
None
0.40A 3d2tB-3fc8A:
22.6
3d2tB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZK_A_T44A128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 9 MET A  13
LEU A  17
ALA A 108
LEU A 110
THR A 118
None
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
1.47A 3ozkA-3fc8A:
24.0
3ozkA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZK_A_T44A128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
8 / 9 MET A  13
LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
VAL A 121
None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
0.56A 3ozkA-3fc8A:
24.0
3ozkA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZK_B_T44B128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LEU A  17
ALA A 108
LEU A 110
THR A 119
VAL A 121
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
0.47A 3ozkB-3fc8A:
23.4
3ozkB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZK_B_T44B128_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.82A 3ozkB-3fc8A:
23.4
3ozkB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.30A 4d7bB-3fc8A:
23.9
4d7bB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LYS A  15
LEU A  17
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.73A 4d7bA-3fc8A:
23.7
4d7bA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 7 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.22A 4d7bA-3fc8A:
23.7
4d7bA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I89_A_1FLA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.64A 4i89A-3fc8A:
24.2
4i89A-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I89_B_1FLB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
ALA A 108
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 (-3.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.13A 4i89B-3fc8A:
22.9
4i89B-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
3 / 3 LYS A  15
LEU A  17
ALA A 108
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
0.28A 4iizA-3fc8A:
23.2
4iizA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
8 / 8 MET A  13
LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.65A 4iizB-3fc8A:
22.4
4iizB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IK6_A_LURA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
ALA A 108
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
None
0.36A 4ik6A-3fc8A:
23.4
4ik6A-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IK6_B_LURB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
8 / 8 MET A  13
LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
VAL A 121
None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.52A 4ik6B-3fc8A:
22.6
4ik6B-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 MET A  13
LYS A  15
LEU A  17
ALA A 108
THR A 118
None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
None
1.30A 4ik7A-3fc8A:
23.7
4ik7A-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
7 / 7 MET A  13
LYS A  15
LEU A  17
THR A 106
ALA A 108
THR A 119
VAL A 121
None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 ( 4.9A)
None
0.52A 4ik7A-3fc8A:
23.7
4ik7A-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
7 / 8 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
0.75A 4ik7B-3fc8A:
22.7
4ik7B-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.78A 4ikiB-3fc8A:
23.0
4ikiB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 6 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
1.04A 4ikiB-3fc8A:
23.0
4ikiB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.63A 4ikjA-3fc8A:
23.6
4ikjB-3fc8A:
22.6
4ikjA-3fc8A:
100.00
4ikjB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.90A 4ikkA-3fc8A:
23.3
4ikkB-3fc8A:
22.4
4ikkA-3fc8A:
100.00
4ikkB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 7 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.63A 4iklA-3fc8A:
24.1
4iklB-3fc8A:
23.1
4iklA-3fc8A:
100.00
4iklB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 8 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.89A 4iklA-3fc8A:
24.1
4iklB-3fc8A:
23.1
4iklA-3fc8A:
100.00
4iklB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.66A 4pwjA-3fc8A:
23.7
4pwjA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 7 LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.38A 4pwjB-3fc8A:
23.5
4pwjB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 7 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.70A 4pwjB-3fc8A:
23.5
4pwjB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.46A 5a6iA-3fc8A:
23.5
5a6iA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 6 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.77A 5a6iA-3fc8A:
23.5
5a6iA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.51A 5bojA-3fc8A:
24.1
5bojA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
7 / 7 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.46A 5bojB-3fc8A:
22.8
5bojB-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CR1_A_T44A201_1
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
5 / 5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.78A 5cr1A-3fc8A:
24.2
5cr1A-3fc8A:
99.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.34A 5l4iA-3fc8A:
24.1
5l4iA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
6 / 6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.30A 5l4iB-3fc8A:
22.8
5l4iB-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
3 / 3 LYS A  15
SER A  50
SER A  52
IFA  A3000 (-3.0A)
None
None
0.85A 6gbfA-3fc8A:
undetectable
6gbfA-3fc8A:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
1.01A 6gnrA-3fc8A:
21.0
6gnrA-3fc8A:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)
3fc8 TRANSTHYRETIN
(Homo
sapiens)
4 / 4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
1.01A 6gnrB-3fc8A:
20.9
6gnrB-3fc8A:
54.55