SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IF6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		4 / 8 GLN A 169
ASP A 216
HIS A 241
GLY A  79
 None
None
None
IF6  A1476 (-3.1A)
 0.96A 1ekjA-5g0qA:
undetectable
1ekjB-5g0qA:
undetectable		 1ekjA-5g0qA:
18.95
1ekjB-5g0qA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		6 / 12 GLY A 103
GLY A 329
GLY A 328
HIS A 327
TYR A  84
GLY A 107
 None
None
None
IF6  A1476 (-4.2A)
None
None
 1.25A 1n2xB-5g0qA:
undetectable		 1n2xB-5g0qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.20A 4hvcB-5g0qA:
undetectable		 4hvcB-5g0qA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.24A 4q15B-5g0qA:
undetectable		 4q15B-5g0qA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 329
 None
None
IF6  A1476 (-2.9A)
None
None
 1.36A 4q15B-5g0qA:
undetectable		 4q15B-5g0qA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.24A 4ydqA-5g0qA:
undetectable		 4ydqA-5g0qA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 329
 None
None
IF6  A1476 (-2.9A)
None
None
 1.37A 4ydqA-5g0qA:
undetectable		 4ydqA-5g0qA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.24A 5f9zA-5g0qA:
undetectable		 5f9zA-5g0qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.28A 5f9zB-5g0qA:
undetectable		 5f9zB-5g0qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		4 / 8 GLU A 287
GLU A 173
GLY A  78
THR A  81
 IF6  A1476 (-1.9A)
IF6  A1476 (-3.1A)
None
None
 1.05A 5sxqB-5g0qA:
undetectable		 5sxqB-5g0qA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		4 / 8 GLU A 287
GLU A 173
GLY A  78
THR A  81
 IF6  A1476 (-1.9A)
IF6  A1476 (-3.1A)
None
None
 1.04A 5syjA-5g0qA:
undetectable		 5syjA-5g0qA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		5 / 12 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.26A 5xiqA-5g0qA:
undetectable		 5xiqA-5g0qA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		4 / 6 TYR A 334
HIS A 241
TYR A 292
GLU A 268
 IF6  A1476 (-4.4A)
None
IF6  A1476 (-4.0A)
None
 1.27A 6gneA-5g0qA:
undetectable		 6gneA-5g0qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5g0q BETA-GLUCURONIDASE
(Acidobacterium
capsulatum) 		4 / 8 TYR A 334
HIS A 241
TYR A 292
GLU A 268
 IF6  A1476 (-4.4A)
None
IF6  A1476 (-4.0A)
None
 1.27A 6gneB-5g0qA:
undetectable		 6gneB-5g0qA:
21.83