SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IEY'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 12	GLU A 212 ARG A 66 MET A 14 GLY A 27 LEU A 42	IEY A 64 ( 3.6A) IEY A 64 ( 3.0A) NFA A 61 ( 3.7A) None NFA A 61 ( 4.3A)	1.05A	2jfaB-2btjA: undetectable	2jfaB-2btjA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BA0_A_HAEA477_1 (MACROPHAGE METALLOELASTASE)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	3 / 3	HIS A 213 GLU A 212 HIS A 194	None IEY A 64 ( 3.6A) IEY A 64 ( 3.6A)	0.82A	3ba0A-2btjA: undetectable	3ba0A-2btjA: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PAE_A_NIZA804_1 (CATALASE-PEROXIDASE)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	4 / 6	PHE A 95 TYR A 169 LEU A 161 THR A 59	None None None IEY A 64 ( 4.2A)	1.26A	4paeA-2btjA: undetectable	4paeA-2btjA: 14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW8_C_FK5C201_1 (FK506-BINDING PROTEIN 1)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 10	TYR A 177 ARG A 91 VAL A 67 TYR A 71 ILE A 196	None IEY A 64 ( 2.9A) None None IEY A 64 ( 3.7A)	1.31A	5hw8C-2btjA: undetectable 5hw8H-2btjA: undetectable	5hw8C-2btjA: 22.22 5hw8H-2btjA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UH6_C_RFPC1201_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 12	GLN A 38 LEU A 210 ASP A 26 ASN A 105 ARG A 13	IEY A 64 ( 3.6A) IEY A 64 ( 3.7A) None IEY A 64 ( 4.3A) None	1.36A	5uh6C-2btjA: 1.3	5uh6C-2btjA: 10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W8A_A_SAMA300_0 (AUTOINDUCER SYNTHASE)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 12	THR A 58 MET A 159 PHE A 173 ILE A 157 THR A 175	None IEY A 64 ( 3.5A) None IEY A 64 ( 4.8A) None	1.22A	5w8aA-2btjA: undetectable	5w8aA-2btjA: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 12	TRP A 89 LEU A 93 HIS A 194 THR A 58 LEU A 57	IEY A 64 ( 4.0A) None IEY A 64 ( 3.6A) None NFA A 61 ( 4.4A)	1.18A	6djzB-2btjA: undetectable	6djzB-2btjA: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWJ_B_GLYB710_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	4 / 5	ARG A 91 ARG A 174 GLY A 155 ASP A 156	IEY A 64 ( 2.9A) None None None	1.22A	6dwjB-2btjA: undetectable 6dwjD-2btjA: undetectable	6dwjB-2btjA: 16.67 6dwjD-2btjA: 16.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"GLU A 212;ARG A  66;MET A  14;GLY A  27;LEU A  42","IEY A  64 ( 3.6A);IEY A  64 ( 3.0A);NFA A  61 ( 3.7A);None;NFA A  61 ( 4.3A)","1.05A","2jfaB-2btjA:undetectable",null],["3BA0_A_HAEA477_1","MACROPHAGE METALLOELASTASE","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",3,"HIS A 213;GLU A 212;HIS A 194","None;IEY A  64 ( 3.6A);IEY A  64 ( 3.6A)","0.82A","3ba0A-2btjA:undetectable","2jfaB-2btjA:19.32"],["4PAE_A_NIZA804_1","CATALASE-PEROXIDASE","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",4,"PHE A  95;TYR A 169;LEU A 161;THR A  59","None;None;None;IEY A  64 ( 4.2A)","1.26A","4paeA-2btjA:undetectable","3ba0A-2btjA:19.18"],["5HW8_C_FK5C201_1","FK506-BINDING PROTEIN 1;FK506-BINDING PROTEIN 1","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"TYR A 177;ARG A  91;VAL A  67;TYR A  71;ILE A 196","None;IEY A  64 ( 2.9A);None;None;IEY A  64 ( 3.7A)","1.31A","5hw8C-2btjA:undetectable;5hw8H-2btjA:undetectable","4paeA-2btjA:14.83"],["5UH6_C_RFPC1201_1","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"GLN A  38;LEU A 210;ASP A  26;ASN A 105;ARG A  13","IEY A  64 ( 3.6A);IEY A  64 ( 3.7A);None;IEY A  64 ( 4.3A);None","1.36A","5uh6C-2btjA:1.3","5hw8C-2btjA:22.22;5hw8H-2btjA:22.22"],["5W8A_A_SAMA300_0","AUTOINDUCER SYNTHASE","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"THR A  58;MET A 159;PHE A 173;ILE A 157;THR A 175","None;IEY A  64 ( 3.5A);None;IEY A  64 ( 4.8A);None","1.22A","5w8aA-2btjA:undetectable","5uh6C-2btjA:10.71"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"TRP A  89;LEU A  93;HIS A 194;THR A  58;LEU A  57","IEY A  64 ( 4.0A);None;IEY A  64 ( 3.6A);None;NFA A  61 ( 4.4A)","1.18A","6djzB-2btjA:undetectable","5w8aA-2btjA:20.33"],["6DWJ_B_GLYB710_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",4,"ARG A  91;ARG A 174;GLY A 155;ASP A 156","IEY A  64 ( 2.9A);None;None;None","1.22A","6dwjB-2btjA:undetectable;6dwjD-2btjA:undetectable","6djzB-2btjA:19.62"]]