SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IDV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
VAL A 109
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.59A 1fmoE-5i3oA:
25.8		 1fmoE-5i3oA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 ASN A 140
LEU A  57
ALA A  77
LEU A  67
 IDV  A 401 ( 4.5A)
IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
 1.05A 1hwiB-5i3oA:
2.5		 1hwiB-5i3oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 ASN A 140
LEU A  57
ALA A  77
LEU A  67
 IDV  A 401 ( 4.5A)
IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
 1.04A 1hwiC-5i3oA:
2.7		 1hwiC-5i3oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-4.4A)
 0.53A 1opjA-5i3oA:
22.2		 1opjA-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
MET A  99
VAL A 109
GLY A 136
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.4A)
 0.89A 1opjB-5i3oA:
21.7		 1opjB-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 9 LEU A  57
VAL A  65
ALA A  77
MET A 130
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.57A 1xbbA-5i3oA:
24.7		 1xbbA-5i3oA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
MET A 130
TYR A 132
ASN A 185
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
 0.82A 2fumB-5i3oA:
25.7		 2fumB-5i3oA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
VAL A  65
ALA A  77
MET A 130
TYR A 132
ASN A 185
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.1A)
 0.62A 2fumC-5i3oA:
24.4		 2fumC-5i3oA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
ALA A  77
LYS A  79
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.77A 2gqgA-5i3oA:
24.8		 2gqgA-5i3oA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.53A 2gqgB-5i3oA:
24.8		 2gqgB-5i3oA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.77A 2hyyA-5i3oA:
22.4		 2hyyA-5i3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.74A 2hyyB-5i3oA:
5.1		 2hyyB-5i3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.43A 2hyyB-5i3oA:
9.9		 2hyyB-5i3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
LYS A  79
MET A  99
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.48A 2hyyC-5i3oA:
22.6		 2hyyC-5i3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
MET A  99
ILE A 128
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.73A 2hyyD-5i3oA:
22.3		 2hyyD-5i3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.85A 2oiqA-5i3oA:
22.0		 2oiqA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
MET A  99
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.72A 2oiqA-5i3oA:
22.0		 2oiqA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.78A 2pl0A-5i3oA:
21.6		 2pl0A-5i3oA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 ALA A  77
LYS A  79
MET A  99
VAL A 109
ILE A 128
TYR A 132
LEU A 187
 IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.81A 2pl0A-5i3oA:
21.6		 2pl0A-5i3oA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 ALA A  77
MET A  99
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.44A 2y6oA-5i3oA:
22.8		 2y6oA-5i3oA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
VAL A 109
CYH A 133
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.79A 3c7qA-5i3oA:
21.5		 3c7qA-5i3oA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 10 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.50A 3cs9A-5i3oA:
22.4		 3cs9A-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 9 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
 0.62A 3cs9B-5i3oA:
22.5		 3cs9B-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 9 LEU A  57
VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.55A 3cs9C-5i3oA:
22.0		 3cs9C-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
VAL A  65
LYS A  79
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-4.4A)
 0.88A 3cs9D-5i3oA:
21.7		 3cs9D-5i3oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
GLY A  60
VAL A  65
ALA A  77
LYS A  79
MET A 130
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.84A 3eygA-5i3oA:
25.5		 3eygA-5i3oA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 GLY A  60
VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
LEU A 187
ASP A 198
 IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.78A 3fupB-5i3oA:
25.6		 3fupB-5i3oA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
GLY A  60
VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.56A 3fupB-5i3oA:
25.6		 3fupB-5i3oA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 11 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
CYH A 133
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.73A 3g0eA-5i3oA:
21.0		 3g0eA-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 11 VAL A  65
ALA A  77
VAL A 109
TYR A 132
CYH A 133
LEU A 187
CYH A 197
ALA A  58
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.3A)
 1.19A 3g0eA-5i3oA:
21.0		 3g0eA-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 11 LEU A  57
VAL A  65
ALA A  77
TYR A 132
CYH A 133
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.76A 3g0fA-5i3oA:
22.0		 3g0fA-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 10 LEU A  57
VAL A  65
ALA A  77
TYR A 132
CYH A 133
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.69A 3g0fB-5i3oA:
22.4		 3g0fB-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.58A 3g5dA-5i3oA:
23.6		 3g5dA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.60A 3g5dA-5i3oA:
23.6		 3g5dA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
MET A  99
VAL A 109
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.70A 3g5dB-5i3oA:
23.5		 3g5dB-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.68A 3g5dB-5i3oA:
23.5		 3g5dB-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
GLU A  95
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.70A 3gvuA-5i3oA:
22.6		 3gvuA-5i3oA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.66A 3k54A-5i3oA:
22.9		 3k54A-5i3oA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.44A 3k5vA-5i3oA:
22.0		 3k5vA-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.53A 3k5vB-5i3oA:
21.8		 3k5vB-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.69A 3lxkA-5i3oA:
25.9		 3lxkA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
TYR A 132
LEU A 187
ASP A 198
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.75A 3lxkA-5i3oA:
25.9		 3lxkA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.39A 3mssD-5i3oA:
22.1		 3mssD-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.71A 3octA-5i3oA:
23.6		 3octA-5i3oA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.63A 3octA-5i3oA:
23.6		 3octA-5i3oA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.62A 3octA-5i3oA:
23.6		 3octA-5i3oA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
ILE A 128
TYR A 132
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.74A 3oezB-5i3oA:
21.9		 3oezB-5i3oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 9 LEU A  57
LYS A  79
ILE A 128
ARG A 179
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
 1.05A 3oxzA-5i3oA:
22.2		 3oxzA-5i3oA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-4.4A)
 0.57A 3pyyB-5i3oA:
21.9		 3pyyB-5i3oA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.70A 3pyyB-5i3oA:
21.9		 3pyyB-5i3oA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.72A 3qlgA-5i3oA:
22.6		 3qlgA-5i3oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.67A 3qlgB-5i3oA:
23.3		 3qlgB-5i3oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.39A 3sxrA-5i3oA:
24.7		 3sxrA-5i3oA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.46A 3sxrA-5i3oA:
24.7		 3sxrA-5i3oA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.45A 3sxrB-5i3oA:
24.2		 3sxrB-5i3oA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
ALA A  77
LYS A  79
GLU A  95
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.74A 3ue4A-5i3oA:
24.4		 3ue4A-5i3oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
VAL A  65
ALA A  77
GLU A  95
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.62A 3ue4B-5i3oA:
24.2		 3ue4B-5i3oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 LEU A  57
VAL A  65
ALA A  77
CYH A 133
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
 0.45A 3wzdA-5i3oA:
22.4		 3wzdA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 LYS A  79
ILE A  98
VAL A 109
LEU A 187
 IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
 0.74A 3wzdA-5i3oA:
22.4		 3wzdA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 8 VAL A 109
CYH A 133
LEU A 187
CYH A 197
ASP A 198
 None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.0A)
 0.63A 3wzeA-5i3oA:
22.7		 3wzeA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 9 LEU A  57
ILE A  98
MET A  99
ILE A 108
TYR A 132
 IDV  A 401 (-3.8A)
None
None
None
IDV  A 401 (-3.5A)
 0.95A 3zosB-5i3oA:
21.6		 3zosB-5i3oA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.67A 4ag8A-5i3oA:
4.7		 4ag8A-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
VAL A 109
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.79A 4ag8A-5i3oA:
4.7		 4ag8A-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
VAL A  65
ALA A  77
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.44A 4agcA-5i3oA:
22.3		 4agcA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 11 LEU A  57
ALA A  77
VAL A 109
CYH A 133
GLY A 136
LEU A 187
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.63A 4agdA-5i3oA:
21.8		 4agdA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LYS A  79
ILE A 128
ASP A 180
LYS A 182
ASN A 185
ASP A 198
 IDV  A 401 ( 4.8A)
None
None
IDV  A 401 ( 4.2A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
 1.03A 4an2A-5i3oA:
23.2		 4an2A-5i3oA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LYS A  79
ILE A 128
MET A 130
ASP A 180
LYS A 182
ASN A 185
 IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
None
IDV  A 401 ( 4.2A)
IDV  A 401 (-4.1A)
 0.79A 4an2A-5i3oA:
23.2		 4an2A-5i3oA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 9 LEU A  57
VAL A  65
ALA A  77
MET A 130
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.45A 4ansA-5i3oA:
23.6		 4ansA-5i3oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
GLY A 136
LEU A 169
HIS A 178
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
None
None
 0.97A 4asdA-5i3oA:
22.3		 4asdA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 VAL A 109
CYH A 133
LEU A 187
CYH A 197
 None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.40A 4asdA-5i3oA:
4.9		 4asdA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
ILE A  98
MET A  99
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.89A 4bkjB-5i3oA:
21.8		 4bkjB-5i3oA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  65
ALA A  77
GLU A  95
ILE A  98
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.91A 4csvA-5i3oA:
22.4		 4csvA-5i3oA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  65
ALA A  77
ILE A  98
MET A  99
VAL A 109
TYR A 132
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.74A 4csvA-5i3oA:
22.4		 4csvA-5i3oA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LYS A  79
ILE A 128
MET A 130
ASN A 185
ASP A 198
PHE A 199
 IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
None
 1.19A 4lmnA-5i3oA:
23.0		 4lmnA-5i3oA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.0A)
 1.04A 4mxoA-5i3oA:
23.3		 4mxoA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.87A 4mxxA-5i3oA:
23.3		 4mxxA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.79A 4mxxB-5i3oA:
22.2		 4mxxB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		10 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
ILE A 128
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.79A 4mxyA-5i3oA:
23.6		 4mxyA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.83A 4mxyB-5i3oA:
23.6		 4mxyB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.89A 4mxyB-5i3oA:
23.6		 4mxyB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		10 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
ILE A 128
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.79A 4mxzA-5i3oA:
23.6		 4mxzA-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.83A 4mxzB-5i3oA:
23.6		 4mxzB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.89A 4mxzB-5i3oA:
23.6		 4mxzB-5i3oA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 8 VAL A  65
ALA A  77
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.49A 4ogrA-5i3oA:
24.4		 4ogrA-5i3oA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 9 VAL A  65
ALA A  77
CYH A 133
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.6A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.50A 4ogrI-5i3oA:
24.7		 4ogrI-5i3oA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
GLY A  60
VAL A  65
ALA A  77
LYS A  79
VAL A 109
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.4A)
 0.62A 4otiA-5i3oA:
21.2		 4otiA-5i3oA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
VAL A 109
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.63A 4otwA-5i3oA:
16.3		 4otwA-5i3oA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
GLU A  95
MET A  99
CYH A 133
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
 0.73A 4r7iA-5i3oA:
22.1		 4r7iA-5i3oA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
VAL A  65
LYS A  79
ILE A 108
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
 0.55A 4tyjA-5i3oA:
22.5		 4tyjA-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 10 LEU A  57
VAL A  65
LEU A 102
ILE A 108
VAL A 109
TYR A 132
ARG A 179
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
None
None
None
IDV  A 401 (-3.5A)
None
 0.88A 4u0iA-5i3oA:
22.6		 4u0iA-5i3oA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 ALA A  77
LYS A  79
CYH A 133
GLY A 136
HIS A 178
LEU A 187
CYH A 197
 IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
None
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.77A 4u0iA-5i3oA:
22.6		 4u0iA-5i3oA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 11 LEU A  57
GLY A  60
VAL A  65
ALA A  77
TYR A 132
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.75A 4u5jA-5i3oA:
24.9		 4u5jA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 11 LEU A  57
VAL A  65
ALA A  77
TYR A 132
GLY A 136
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.76A 4u5jA-5i3oA:
24.9		 4u5jA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 9 LEU A  57
VAL A  65
ALA A  77
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.55A 4u5jB-5i3oA:
24.0		 4u5jB-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 9 LEU A  57
VAL A  65
LYS A  79
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.39A 4v01A-5i3oA:
21.7		 4v01A-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 LYS A  79
MET A  99
TYR A 132
LEU A 187
 IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.70A 4v04A-5i3oA:
21.6		 4v04A-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 10 LEU A  57
VAL A  65
LYS A  79
MET A  99
TYR A 132
ARG A 179
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
None
IDV  A 401 (-4.4A)
 1.31A 4v04B-5i3oA:
21.9		 4v04B-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A  57
ALA A  77
MET A 130
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.71A 4wboC-5i3oA:
23.6		 4wboC-5i3oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
LYS A  79
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.77A 4wkqA-5i3oA:
24.0		 4wkqA-5i3oA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.53A 4xeyB-5i3oA:
23.7		 4xeyB-5i3oA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  65
ALA A  77
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.56A 4xeyB-5i3oA:
23.7		 4xeyB-5i3oA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.62A 4xliA-5i3oA:
25.1		 4xliA-5i3oA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
ALA A  77
LYS A  79
MET A  99
VAL A 109
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.70A 4xliB-5i3oA:
25.1		 4xliB-5i3oA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
ALA A  77
CYH A 133
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.54A 5ajqA-5i3oA:
23.2		 5ajqA-5i3oA:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.79A 5bvwA-5i3oA:
21.5		 5bvwA-5i3oA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
MET A  99
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.68A 5bvwA-5i3oA:
21.5		 5bvwA-5i3oA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 LEU A  57
ALA A  77
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.54A 5h2uC-5i3oA:
23.0		 5h2uC-5i3oA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
VAL A  65
ALA A  77
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.51A 5h2uD-5i3oA:
17.1		 5h2uD-5i3oA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
ILE A 128
TYR A 132
CYH A 197
PHE A 199
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.6A)
None
 0.93A 5hesA-5i3oA:
21.3		 5hesA-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
ILE A 128
TYR A 132
CYH A 197
PHE A 199
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.6A)
None
 0.97A 5hesB-5i3oA:
21.2		 5hesB-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
LYS A  79
ILE A 128
CYH A 197
GLY A 200
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.6A)
None
 1.24A 5hesB-5i3oA:
21.2		 5hesB-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  65
ALA A  77
LYS A  79
ILE A 128
CYH A 197
PHE A 199
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.6A)
None
 0.90A 5hesB-5i3oA:
21.2		 5hesB-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 ALA A  77
LYS A  79
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.58A 5i9xA-5i3oA:
23.0		 5i9xA-5i3oA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 VAL A 109
GLN A 137
CYH A 133
 None
IDV  A 401 (-3.7A)
IDV  A 401 (-4.6A)
 0.81A 5icxC-5i3oA:
2.5
5icxF-5i3oA:
undetectable		 5icxC-5i3oA:
19.80
5icxF-5i3oA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 11 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.63A 5lvnA-5i3oA:
25.9		 5lvnA-5i3oA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 10 LEU A  57
VAL A  65
LYS A  79
ILE A 128
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
 0.62A 5mo4A-5i3oA:
18.9		 5mo4A-5i3oA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 10 LEU A  57
VAL A  65
ALA A  77
VAL A 109
MET A 130
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.63A 5n3hA-5i3oA:
25.8		 5n3hA-5i3oA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 8 ALA A  77
GLU A  95
CYH A 133
LEU A 187
ASP A 198
 IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.78A 5owrA-5i3oA:
10.1		 5owrA-5i3oA:
29.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 GLU A  55
ALA A  58
LEU A  67
ALA A  77
GLU A  95
MET A  99
VAL A 109
LEU A 187
 None
IDV  A 401 (-3.3A)
None
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.93A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLU A  55
LEU A  67
ALA A  77
GLU A  95
MET A  99
VAL A 109
GLY A 136
GLN A 137
LEU A 187
 None
None
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 (-4.4A)
 0.85A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 GLU A  55
LEU A  67
GLU A  95
VAL A 109
GLY A 136
GLN A 137
ASN A 140
LEU A 187
 None
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 ( 4.5A)
IDV  A 401 (-4.4A)
 0.99A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 5 LEU A  57
VAL A  65
MET A 130
CYH A 133
CYH A 197
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
 0.68A 5te0A-5i3oA:
36.4		 5te0A-5i3oA:
77.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 GLU A  55
ALA A  77
TYR A 132
CYH A 133
GLY A 136
ASP A 198
 None
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.0A)
 0.82A 5vc3A-5i3oA:
15.2		 5vc3A-5i3oA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  57
ALA A  77
LYS A  79
GLU A  95
VAL A 109
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
 0.99A 5vcvA-5i3oA:
25.0		 5vcvA-5i3oA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		5 / 9 LEU A  57
ALA A  77
VAL A 109
CYH A 133
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
 0.67A 5w5vA-5i3oA:
14.4		 5w5vA-5i3oA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
GLU A  95
CYH A 133
GLY A 136
GLN A 137
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 (-4.4A)
 0.74A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
ALA A  77
GLU A  95
CYH A 133
GLY A 136
GLN A 137
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 (-4.4A)
 0.74A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.64A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.64A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
CYH A 197
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.0A)
 0.64A 5y7zB-5i3oA:
33.2		 5y7zB-5i3oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.72A 5y80A-5i3oA:
10.0		 5y80A-5i3oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.73A 6bsdA-5i3oA:
21.4		 6bsdA-5i3oA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  65
ALA A  77
LYS A  79
MET A  99
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.67A 6bsdA-5i3oA:
21.4		 6bsdA-5i3oA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.74A 6hd4A-5i3oA:
21.9		 6hd4A-5i3oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.74A 6hd4B-5i3oA:
21.8		 6hd4B-5i3oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.72A 6hd6A-5i3oA:
21.9		 6hd6A-5i3oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 LEU A  57
VAL A  65
ALA A  77
LYS A  79
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
 0.68A 6hd6B-5i3oA:
16.8		 6hd6B-5i3oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-4.4A)
 0.79A 6hd6B-5i3oA:
16.8		 6hd6B-5i3oA:
19.53