SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IBM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 THR A 795
ASP A 722
HIS A 681
HIS A 685
 MG  A   2 ( 4.7A)
MG  A   2 ( 2.6A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-3.4A)
 1.00A 1ei6D-2r8qA:
undetectable		 1ei6D-2r8qA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 10 ILE A 158
ASN A 365
PHE A 156
TYR A 227
ALA A 361
 None
IBM  A 503 ( 4.7A)
None
None
None
 1.24A 1ju6C-1zklA:
undetectable		 1ju6C-1zklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 9 TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.79A 1tbfA-1zklA:
38.5		 1tbfA-1zklA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.79A 1udtA-1zklA:
35.3		 1udtA-1zklA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.52A 1udtA-2r8qA:
38.2		 1udtA-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 12 TYR A 555
HIS A 556
ALA A 742
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 1.25A 1udtA-3ecnA:
35.2		 1udtA-3ecnA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 11 TYR A 211
VAL A 380
PHE A 384
LEU A 401
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.88A 1uduA-1zklA:
34.1		 1uduA-1zklA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.58A 1uduA-2r8qA:
37.0		 1uduA-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.73A 1uduB-1zklA:
34.2		 1uduB-1zklA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.58A 1uduB-2r8qA:
37.0		 1uduB-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 10 TYR A 736
HIS A 737
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.31A 1uhoA-1sojA:
34.7		 1uhoA-1sojA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 10 TYR A 211
HIS A 212
PHE A 384
GLN A 413
GLY A 415
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
 0.62A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 10 TYR A 211
HIS A 212
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.76A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 10 TYR A 211
HIS A 216
GLN A 413
GLY A 415
PHE A 416
 IBM  A 503 (-4.6A)
ZN  A 501 (-3.3A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
 1.43A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 10 TYR A 680
HIS A 681
PHE A 857
GLN A 887
GLY A 889
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
None
IBM  A   3 (-3.6A)
 0.63A 1uhoA-2r8qA:
38.1		 1uhoA-2r8qA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
HIS A 825
THR A 952
ILE A 955
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.59A 1xlxA-1sojA:
41.6		 1xlxA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
HIS A 256
ASN A 365
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 ( 4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.42A 1xlxA-1zklA:
45.3		 1xlxA-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
ASN A 838
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.64A 1xlxA-2r8qA:
39.7		 1xlxA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
None
 1.41A 1xlxA-2r8qA:
39.7		 1xlxA-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		9 / 12 TYR A 555
HIS A 556
HIS A 600
MET A 670
ASN A 729
ILE A 744
SER A 777
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.42A 1xlxA-3ecnA:
44.7		 1xlxA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
HIS A 296
MET A 365
ASN A 405
GLN A 453
 None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
 0.83A 1xlxA-3n3zA:
41.1		 1xlxA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
HIS A 296
MET A 365
GLN A 453
PHE A 456
 None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.63A 1xlxA-3n3zA:
41.1		 1xlxA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		8 / 12 TYR A 736
HIS A 737
HIS A 825
THR A 952
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.53A 1xlxB-1sojA:
41.8		 1xlxB-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
HIS A 256
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.53A 1xlxB-1zklA:
45.1		 1xlxB-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
None
 1.49A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 12 HIS A 556
HIS A 600
ILE A 744
SER A 777
PHE A 781
 None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.69A 1xlxB-3ecnA:
44.9		 1xlxB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		7 / 12 TYR A 555
HIS A 556
HIS A 600
MET A 670
ILE A 744
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.33A 1xlxB-3ecnA:
44.9		 1xlxB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
HIS A 296
MET A 365
GLN A 453
PHE A 456
 None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.57A 1xlxB-3n3zA:
40.8		 1xlxB-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 292
MET A 365
PHE A 251
GLN A 453
PHE A 456
 ZN  A 507 (-3.5A)
None
IBM  A   1 ( 4.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 1.30A 1xlxB-3n3zA:
40.8		 1xlxB-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
 IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
 1.24A 1xmuA-1sojA:
41.8		 1xmuA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		8 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
ILE A 955
PHE A 959
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.6A)
 0.57A 1xmuA-1sojA:
41.8		 1xmuA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 384
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.4A)
 0.34A 1xmuA-1zklA:
45.2		 1xmuA-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
ASP A 835
TRP A 849
PHE A 857
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.6A)
 0.37A 1xmuA-2r8qA:
39.8		 1xmuA-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
 None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.37A 1xmuA-3ecnA:
44.6		 1xmuA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
ILE A 955
PHE A 959
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-4.2A)
None
 0.48A 1xmuB-1sojA:
41.8		 1xmuB-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 384
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-4.5A)
 0.24A 1xmuB-1zklA:
45.2		 1xmuB-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
PHE A 857
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.9A)
 0.36A 1xmuB-2r8qA:
39.8		 1xmuB-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
 0.38A 1xmuB-3ecnA:
44.7		 1xmuB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
ASP A 937
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.54A 1xomA-1sojA:
42.2		 1xomA-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.58A 1xomA-1zklA:
45.6		 1xomA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		8 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.78A 1xomA-2r8qA:
39.4		 1xomA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
ILE A 744
SER A 777
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.37A 1xomA-3ecnA:
44.8		 1xomA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
MET A 365
ASP A 402
GLN A 453
PHE A 456
 None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.58A 1xomA-3n3zA:
41.3		 1xomA-3n3zA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
THR A 952
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.54A 1xomB-1sojA:
42.3		 1xomB-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.61A 1xomB-1zklA:
45.4		 1xomB-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xomB-2r8qA:
39.4		 1xomB-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		7 / 12 TYR A 555
HIS A 556
MET A 670
ILE A 744
SER A 777
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.41A 1xomB-3ecnA:
45.0		 1xomB-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
 IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
 1.24A 1xoqA-1sojA:
42.0		 1xoqA-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
THR A 952
ILE A 955
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
 0.52A 1xoqA-1sojA:
42.0		 1xoqA-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
IBM  A 503 (-3.4A)
 0.37A 1xoqA-1zklA:
45.5		 1xoqA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-3.6A)
 0.39A 1xoqA-2r8qA:
39.4		 1xoqA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.29A 1xoqA-2r8qA:
39.4		 1xoqA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 12 MET A 670
ASP A 726
PRO A 730
SER A 780
PHE A 781
 IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-3.5A)
 1.12A 1xoqA-3ecnA:
44.9		 1xoqA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
ILE A 744
SER A 777
PHE A 781
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.41A 1xoqA-3ecnA:
44.9		 1xoqA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		3 / 3 ASN A 365
TRP A 376
GLN A 413
 IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
 0.20A 1xoqA-1zklA:
45.5		 1xoqA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 ASN A 838
TRP A 849
GLN A 887
 IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.3A)
 0.36A 1xoqA-2r8qA:
39.4		 1xoqA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		3 / 3 ASN A 729
TRP A 740
GLN A 778
 None
None
IBM  A   3 (-3.4A)
 0.16A 1xoqA-3ecnA:
44.9		 1xoqA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		3 / 3 ASN A 405
TRP A 416
GLN A 453
 IBM  A   1 (-3.5A)
None
IBM  A   1 (-3.5A)
 0.86A 1xoqA-3n3zA:
41.3		 1xoqA-3n3zA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
 IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
 1.25A 1xoqB-1sojA:
42.2		 1xoqB-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		8 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
 0.52A 1xoqB-1sojA:
42.2		 1xoqB-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
 0.36A 1xoqB-1zklA:
45.5		 1xoqB-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
ASP A 835
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.6A)
 0.42A 1xoqB-2r8qA:
39.4		 1xoqB-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
 None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.37A 1xoqB-3ecnA:
45.0		 1xoqB-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 MET A 797
ASN A 838
GLN A 887
 None
IBM  A   3 (-4.5A)
IBM  A   3 (-3.3A)
 0.58A 1xoqB-2r8qA:
39.4		 1xoqB-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		3 / 3 MET A 670
ASN A 729
GLN A 778
 IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.4A)
 0.34A 1xoqB-3ecnA:
45.0		 1xoqB-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		3 / 3 MET A 365
ASN A 405
GLN A 453
 None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
 0.88A 1xoqB-3n3zA:
41.3		 1xoqB-3n3zA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
ASP A 937
PHE A 959
GLN A 988
PHE A 991
ILE A 995
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
 0.52A 1xosA-1sojA:
41.8		 1xosA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 12 TYR A 736
HIS A 737
ASP A 937
PHE A 959
SER A 974
GLN A 988
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.3A)
 1.00A 1xosA-1sojA:
41.8		 1xosA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 TYR A 736
HIS A 741
GLN A 988
PHE A 991
ILE A 995
 IBM  A2111 (-4.5A)
MG  A2123 (-3.0A)
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
 1.48A 1xosA-1sojA:
41.8		 1xosA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.47A 1xosA-1zklA:
45.2		 1xosA-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.76A 1xosA-2r8qA:
39.8		 1xosA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.52A 1xosA-2r8qA:
39.8		 1xosA-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		6 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.44A 1xosA-3ecnA:
44.8		 1xosA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
MET A 365
ASP A 402
GLN A 453
PHE A 456
 None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.51A 1xosA-3n3zA:
41.3		 1xosA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
ILE A 955
SER A 974
GLN A 988
PHE A 991
ILE A 995
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
 0.67A 1xotA-1sojA:
41.8		 1xotA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
SER A 399
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.87A 1xotA-1zklA:
45.3		 1xotA-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.50A 1xotA-2r8qA:
39.6		 1xotA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
MET A 797
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
None
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xotA-2r8qA:
39.6		 1xotA-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		6 / 12 TYR A 555
HIS A 556
ILE A 744
GLN A 778
PHE A 781
ILE A 786
 None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
None
 1.31A 1xotA-3ecnA:
44.8		 1xotA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		7 / 12 TYR A 555
HIS A 556
MET A 670
ILE A 744
SER A 777
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.57A 1xotA-3ecnA:
44.8		 1xotA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 12 TYR A 736
HIS A 737
ILE A 955
SER A 974
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.51A 1xotB-1sojA:
41.9		 1xotB-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASN A 365
SER A 399
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.67A 1xotB-1zklA:
45.2		 1xotB-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
ASN A 838
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.5A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.72A 1xotB-2r8qA:
39.8		 1xotB-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		6 / 12 TYR A 555
HIS A 556
ASN A 729
ILE A 744
SER A 777
PHE A 781
 None
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.60A 1xotB-3ecnA:
44.7		 1xotB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		7 / 12 TYR A 555
HIS A 556
MET A 670
ASN A 729
ILE A 744
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.40A 1xotB-3ecnA:
44.7		 1xotB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
MET A 365
ASN A 405
GLN A 453
PHE A 456
 None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.80A 1xotB-3n3zA:
41.2		 1xotB-3n3zA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.82A 1xozA-1zklA:
38.4		 1xozA-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.87A 1xozA-1zklA:
38.4		 1xozA-1zklA:
29.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.49A 1xozA-2r8qA:
40.5		 1xozA-2r8qA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 10 TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.85A 1xp0A-1zklA:
38.6		 1xp0A-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 11 TYR A 736
HIS A 737
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.37A 2h42A-1sojA:
34.3		 2h42A-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 11 TYR A 211
HIS A 212
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.66A 2h42A-1zklA:
34.9		 2h42A-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 11 TYR A 211
HIS A 212
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.81A 2h42A-1zklA:
34.9		 2h42A-1zklA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.59A 2h42A-2r8qA:
38.4		 2h42A-2r8qA:
31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 11 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.37A 2h42A-3ecnA:
35.0		 2h42A-3ecnA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.68A 2h42B-1zklA:
34.8		 2h42B-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
VAL A 380
LEU A 401
GLN A 413
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
 0.92A 2h42B-1zklA:
34.8		 2h42B-1zklA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 2h42B-2r8qA:
38.1		 2h42B-2r8qA:
31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 12 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.46A 2h42B-3ecnA:
34.8		 2h42B-3ecnA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 TYR A 736
LEU A 895
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.41A 2h42C-1sojA:
34.1		 2h42C-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.72A 2h42C-1zklA:
34.9		 2h42C-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
VAL A 380
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.54A 2h42C-1zklA:
34.9		 2h42C-1zklA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.56A 2h42C-2r8qA:
38.1		 2h42C-2r8qA:
31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		8 / 12 TYR A 736
HIS A 737
LEU A 895
ILE A 955
GLU A 958
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-4.2A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.59A 2weyA-1sojA:
36.5		 2weyA-1sojA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
GLU A 383
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.74A 2weyA-1zklA:
36.9		 2weyA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
GLU A 856
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.70A 2weyA-2r8qA:
38.9		 2weyA-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
VAL A 839
GLU A 856
PHE A 857
MET A 874
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.69A 2weyA-2r8qA:
38.9		 2weyA-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		6 / 12 TYR A 555
HIS A 556
ILE A 744
GLU A 747
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.92A 2weyA-3ecnA:
36.5		 2weyA-3ecnA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 8 LEU A 895
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 None
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.35A 2weyB-1sojA:
36.2		 2weyB-1sojA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.59A 2weyB-2r8qA:
39.1		 2weyB-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 VAL A 839
PHE A 857
MET A 874
PHE A 890
 None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.63A 2weyB-2r8qA:
39.1		 2weyB-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		4 / 8 HIS A 821
ASP A 937
ILE A 938
HIS A 741
 MG  A2123 (-3.1A)
MG  A2123 (-2.5A)
IBM  A2111 (-4.1A)
MG  A2123 (-3.0A)
 1.05A 2xadA-1sojA:
undetectable		 2xadA-1sojA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
 ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
 0.99A 2xadA-3n3zA:
undetectable		 2xadA-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		4 / 8 HIS A 821
ASP A 937
ILE A 938
HIS A 741
 MG  A2123 (-3.1A)
MG  A2123 (-2.5A)
IBM  A2111 (-4.1A)
MG  A2123 (-3.0A)
 1.09A 2xadB-1sojA:
undetectable		 2xadB-1sojA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
 ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
 1.02A 2xadB-3n3zA:
undetectable		 2xadB-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		4 / 8 HIS A 821
ASP A 937
ILE A 938
HIS A 741
 MG  A2123 (-3.1A)
MG  A2123 (-2.5A)
IBM  A2111 (-4.1A)
MG  A2123 (-3.0A)
 1.07A 2xadC-1sojA:
undetectable		 2xadC-1sojA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
 ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
 1.02A 2xadC-3n3zA:
undetectable		 2xadC-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		4 / 8 HIS A 821
ASP A 937
ILE A 938
HIS A 741
 MG  A2123 (-3.1A)
MG  A2123 (-2.5A)
IBM  A2111 (-4.1A)
MG  A2123 (-3.0A)
 1.07A 2xadD-1sojA:
undetectable		 2xadD-1sojA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 8 HIS A 292
ASP A 402
ILE A 403
HIS A 256
 ZN  A 507 (-3.5A)
ZN  A 507 (-2.9A)
IBM  A   1 (-4.3A)
ZN  A 507 (-3.8A)
 1.01A 2xadD-3n3zA:
undetectable		 2xadD-3n3zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 MET A 874
GLU A 856
ASP A 722
 IBM  A   3 ( 3.8A)
None
MG  A   2 ( 2.6A)
 1.04A 3a25A-2r8qA:
undetectable		 3a25A-2r8qA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 7 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.00A 3asnP-3n3zA:
3.3
3asnW-3n3zA:
undetectable		 3asnP-3n3zA:
21.17
3asnW-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 7 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.01A 3asoP-3n3zA:
3.2
3asoW-3n3zA:
undetectable		 3asoP-3n3zA:
21.17
3asoW-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 TYR A 736
HIS A 737
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.50A 3b2rA-1sojA:
30.1		 3b2rA-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 12 TYR A 211
HIS A 212
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.86A 3b2rA-1zklA:
30.7		 3b2rA-1zklA:
28.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 3b2rA-2r8qA:
33.6		 3b2rA-2r8qA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 12 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.58A 3b2rA-3ecnA:
30.5		 3b2rA-3ecnA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 11 TYR A 211
HIS A 212
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.78A 3b2rB-1zklA:
30.6		 3b2rB-1zklA:
28.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.41A 3b2rB-2r8qA:
33.4		 3b2rB-2r8qA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 11 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.55A 3b2rB-3ecnA:
30.7		 3b2rB-3ecnA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 HIS A 741
HIS A 821
PHE A 991
THR A 893
VAL A 996
 MG  A2123 (-3.0A)
MG  A2123 (-3.1A)
IBM  A2111 (-3.6A)
None
None
 1.23A 3czvA-1sojA:
undetectable
3czvB-1sojA:
undetectable		 3czvA-1sojA:
21.65
3czvB-1sojA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 HIS A 216
HIS A 252
PHE A 416
THR A 321
VAL A 421
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
IBM  A 503 (-3.4A)
None
None
 1.18A 3czvA-1zklA:
undetectable
3czvB-1zklA:
undetectable		 3czvA-1zklA:
19.72
3czvB-1zklA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 12 TYR A 736
HIS A 737
PRO A 941
SER A 990
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.6A)
 1.25A 3g4lA-1sojA:
42.0		 3g4lA-1sojA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
 0.53A 3g4lA-1sojA:
42.0		 3g4lA-1sojA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASN A 365
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 ( 4.7A)
None
None
IBM  A 503 (-3.4A)
 0.42A 3g4lA-1zklA:
45.4		 3g4lA-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASN A 838
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.6A)
 0.40A 3g4lA-2r8qA:
38.8		 3g4lA-2r8qA:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 12 MET A 670
ASN A 729
PRO A 730
SER A 780
PHE A 781
 IBM  A   3 (-4.5A)
None
None
None
IBM  A   3 (-3.5A)
 1.01A 3g4lA-3ecnA:
44.8		 3g4lA-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		9 / 12 TYR A 555
HIS A 556
MET A 670
ASN A 729
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
 None
None
IBM  A   3 (-4.5A)
None
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.43A 3g4lA-3ecnA:
44.8		 3g4lA-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		8 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
 0.48A 3g4lB-1sojA:
41.7		 3g4lB-1sojA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
 0.44A 3g4lB-1zklA:
45.4		 3g4lB-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.27A 3g4lB-2r8qA:
38.9		 3g4lB-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.6A)
 0.41A 3g4lB-2r8qA:
38.9		 3g4lB-2r8qA:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
PHE A 781
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.5A)
 0.33A 3g4lB-3ecnA:
44.8		 3g4lB-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
MET A 365
ASP A 402
TRP A 416
PHE A 456
 None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.4A)
 0.60A 3g4lB-3n3zA:
41.0		 3g4lB-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		7 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
 0.49A 3g4lC-1sojA:
41.6		 3g4lC-1sojA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
ASN A 365
PRO A 366
TRP A 376
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 ( 4.7A)
None
None
 0.25A 3g4lC-1zklA:
45.3		 3g4lC-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
ASN A 838
TRP A 849
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.5A)
None
 0.41A 3g4lC-2r8qA:
38.9		 3g4lC-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.27A 3g4lC-2r8qA:
38.9		 3g4lC-2r8qA:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
ASN A 729
PRO A 730
TRP A 740
ILE A 744
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
None
IBM  A   3 (-4.3A)
 0.31A 3g4lC-3ecnA:
44.8		 3g4lC-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
MET A 365
ASP A 402
ASN A 405
TRP A 416
 None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
None
 0.85A 3g4lC-3n3zA:
41.1		 3g4lC-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		3 / 3 SER A 777
GLN A 778
PHE A 781
 None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.22A 3g4lC-3ecnA:
44.8		 3g4lC-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		8 / 12 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
GLN A 988
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.3A)
 0.51A 3g4lD-1sojA:
41.3		 3g4lD-1sojA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
GLN A 413
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.0A)
 0.36A 3g4lD-1zklA:
45.1		 3g4lD-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.30A 3g4lD-2r8qA:
39.2		 3g4lD-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
GLN A 887
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.3A)
 0.45A 3g4lD-2r8qA:
39.2		 3g4lD-2r8qA:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		9 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
GLN A 778
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
 0.41A 3g4lD-3ecnA:
44.7		 3g4lD-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 HIS A 252
MET A 365
ASP A 402
TRP A 416
GLN A 453
 None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.5A)
 0.62A 3g4lD-3n3zA:
40.9		 3g4lD-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 9 TYR A 736
ILE A 955
PHE A 959
GLN A 988
PHE A 991
ILE A 995
 IBM  A2111 (-4.5A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
 0.58A 3iakA-1sojA:
42.0		 3iakA-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 9 TYR A 211
ASN A 365
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.53A 3iakA-1zklA:
44.9		 3iakA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 9 TYR A 680
MET A 797
ASN A 838
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.74A 3iakA-2r8qA:
38.9		 3iakA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 9 TYR A 680
MET A 797
ASN A 838
PHE A 857
MET A 874
PHE A 890
 IBM  A   3 ( 4.7A)
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.85A 3iakA-2r8qA:
38.9		 3iakA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 9 TYR A 555
ILE A 744
GLN A 778
PHE A 781
ILE A 786
 None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
None
 1.45A 3iakA-3ecnA:
43.0		 3iakA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		6 / 9 TYR A 555
MET A 670
ASN A 729
ILE A 744
GLN A 778
PHE A 781
 None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.53A 3iakA-3ecnA:
43.0		 3iakA-3ecnA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 9 TYR A 736
HIS A 737
LEU A 895
LEU A 984
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.52A 3jwqA-1sojA:
37.4		 3jwqA-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 9 TYR A 211
HIS A 212
VAL A 380
GLN A 413
PHE A 416
VAL A 421
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
None
 1.33A 3jwqA-1zklA:
38.1		 3jwqA-1zklA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 9 TYR A 680
HIS A 681
VAL A 853
LEU A 883
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.66A 3jwqA-2r8qA:
40.5		 3jwqA-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 9 TYR A 680
HIS A 681
VAL A 853
MET A 874
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.67A 3jwqA-2r8qA:
40.5		 3jwqA-2r8qA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 11 TYR A 736
HIS A 737
LEU A 895
LEU A 984
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.66A 3jwqB-1sojA:
37.3
3jwqC-1sojA:
37.3		 3jwqB-1sojA:
24.24
3jwqC-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 11 TYR A 211
HIS A 212
ASN A 260
VAL A 380
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.82A 3jwqB-1zklA:
37.8
3jwqC-1zklA:
38.0		 3jwqB-1zklA:
27.69
3jwqC-1zklA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 HIS A 681
ASN A 729
VAL A 853
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.8A)
None
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 3jwqB-2r8qA:
40.5
3jwqC-2r8qA:
40.3		 3jwqB-2r8qA:
31.58
3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
VAL A 853
LEU A 883
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.76A 3jwqB-2r8qA:
40.5
3jwqC-2r8qA:
40.3		 3jwqB-2r8qA:
31.58
3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
VAL A 853
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.67A 3jwqB-2r8qA:
40.5
3jwqC-2r8qA:
40.3		 3jwqB-2r8qA:
31.58
3jwqC-2r8qA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 7 TYR A 736
HIS A 737
LEU A 984
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.55A 3jwqC-1sojA:
37.3		 3jwqC-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 7 TYR A 211
HIS A 212
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.64A 3jwqC-1zklA:
38.0		 3jwqC-1zklA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 7 TYR A 680
HIS A 681
LEU A 883
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.62A 3jwqC-2r8qA:
40.3		 3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 7 TYR A 680
HIS A 681
MET A 874
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.70A 3jwqC-2r8qA:
40.3		 3jwqC-2r8qA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		4 / 7 TYR A 555
HIS A 556
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.43A 3jwqC-3ecnA:
37.9		 3jwqC-3ecnA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 7 HIS A 252
GLN A 453
PHE A 456
VAL A 460
 None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
None
 0.57A 3jwqC-3n3zA:
41.8		 3jwqC-3n3zA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 7 HIS A 256
GLN A 453
PHE A 456
VAL A 460
 ZN  A 507 (-3.8A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
None
 0.83A 3jwqC-3n3zA:
41.8		 3jwqC-3n3zA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 11 GLN A 962
TYR A 736
HIS A 737
LEU A 984
GLN A 988
 None
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
 1.47A 3jwqA-1sojA:
37.4
3jwqD-1sojA:
37.1		 3jwqA-1sojA:
24.24
3jwqD-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 11 TYR A 736
HIS A 737
LEU A 895
LEU A 984
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 1.07A 3jwqA-1sojA:
37.4
3jwqD-1sojA:
37.1		 3jwqA-1sojA:
24.24
3jwqD-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 11 TYR A 736
HIS A 737
LEU A 895
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.45A 3jwqA-1sojA:
37.4
3jwqD-1sojA:
37.1		 3jwqA-1sojA:
24.24
3jwqD-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 11 TYR A 211
HIS A 212
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.61A 3jwqA-1zklA:
38.1
3jwqD-1zklA:
37.7		 3jwqA-1zklA:
27.69
3jwqD-1zklA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 TYR A 680
HIS A 681
LEU A 883
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 1.14A 3jwqA-2r8qA:
40.5
3jwqD-2r8qA:
40.0		 3jwqA-2r8qA:
31.58
3jwqD-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.77A 3jwqA-2r8qA:
40.5
3jwqD-2r8qA:
40.0		 3jwqA-2r8qA:
31.58
3jwqD-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		6 / 9 TYR A 736
PRO A 941
THR A 952
ILE A 955
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.53A 3tvxA-1sojA:
41.2		 3tvxA-1sojA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 9 TYR A 211
ASN A 365
PRO A 366
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.56A 3tvxA-1zklA:
45.2		 3tvxA-1zklA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		6 / 9 TYR A 555
ASN A 729
PRO A 730
ILE A 744
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.36A 3tvxA-3ecnA:
44.3		 3tvxA-3ecnA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		5 / 7 TYR A 736
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.59A 3tvxB-1sojA:
41.3		 3tvxB-1sojA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 7 TYR A 211
ASN A 365
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.57A 3tvxB-1zklA:
45.1		 3tvxB-1zklA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 7 TYR A 680
ASN A 838
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.77A 3tvxB-2r8qA:
39.6		 3tvxB-2r8qA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens) 		5 / 7 TYR A 555
ASN A 729
ILE A 744
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.38A 3tvxB-3ecnA:
44.5		 3tvxB-3ecnA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 6 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.03A 3wg7C-3n3zA:
3.3
3wg7J-3n3zA:
1.4		 3wg7C-3n3zA:
21.17
3wg7J-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 6 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 0.97A 3wg7P-3n3zA:
3.2
3wg7W-3n3zA:
undetectable		 3wg7P-3n3zA:
21.17
3wg7W-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 4 ILE A 323
SER A 324
ASP A 253
ASP A 255
 IBM  A 503 ( 4.8A)
None
MG  A 502 ( 2.6A)
None
 1.48A 4krhB-1zklA:
undetectable		 4krhB-1zklA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		5 / 12 ALA A 406
LEU A 420
MET A 365
HIS A 368
LEU A 483
 IBM  A   1 ( 4.7A)
IBM  A   1 (-4.8A)
None
None
None
 1.08A 4zn7A-3n3zA:
undetectable		 4zn7A-3n3zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 8 GLU A 856
VAL A 678
HIS A 681
ASP A 722
HIS A 757
 None
None
IBM  A   3 ( 4.8A)
MG  A   2 ( 2.6A)
None
 1.24A 5f8yA-2r8qA:
undetectable		 5f8yA-2r8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 8 GLU A 856
VAL A 678
HIS A 681
ASP A 722
HIS A 757
 None
None
IBM  A   3 ( 4.8A)
MG  A   2 ( 2.6A)
None
 1.27A 5f8yB-2r8qA:
undetectable		 5f8yB-2r8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens) 		3 / 3 HIS A 741
HIS A 737
HIS A 825
 MG  A2123 (-3.0A)
IBM  A2111 ( 4.8A)
None
 1.00A 5oexA-1sojA:
undetectable		 5oexA-1sojA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens) 		4 / 5 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.02A 5x19C-3n3zA:
undetectable
5x19J-3n3zA:
undetectable		 5x19C-3n3zA:
21.17
5x19J-3n3zA:
9.82