SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IBI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		7 / 7 TRP A  50
PRO A  51
LEU A  61
LEU A  63
ASN A 109
ILE A 115
MET A 118
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
None
 0.48A 3u5jA-5vbrA:
19.3		 3u5jA-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		8 / 8 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
MET A 118
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
None
 0.49A 3u5kA-5vbrA:
19.3		 3u5kA-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		6 / 7 TRP A  50
PRO A  51
VAL A  56
LEU A  61
ASN A 109
ILE A 115
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.55A 3u5kB-5vbrA:
19.4		 3u5kB-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		6 / 7 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
 0.50A 3u5kB-5vbrA:
19.4		 3u5kB-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		8 / 8 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
MET A 118
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
None
 0.55A 3u5kC-5vbrA:
19.1		 3u5kC-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		8 / 8 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
MET A 118
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
None
 0.49A 3u5kD-5vbrA:
19.4		 3u5kD-5vbrA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		5 / 5 VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
 IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.76A 4a9jA-5vbrA:
20.2		 4a9jA-5vbrA:
55.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		5 / 5 VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
 IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.68A 4a9jB-5vbrA:
20.3		 4a9jB-5vbrA:
55.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		5 / 5 VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
 IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.66A 4a9jC-5vbrA:
20.1		 4a9jC-5vbrA:
55.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		4 / 6 VAL A  56
LEU A  61
TYR A 108
ASN A 109
 IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 ( 4.5A)
IBI  A 201 (-3.3A)
 0.77A 4a9kA-5vbrA:
17.4		 4a9kA-5vbrA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		8 / 9 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
MET A 118
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
None
 0.50A 4c66A-5vbrA:
19.2		 4c66A-5vbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		4 / 6 PRO A  51
VAL A  56
TYR A  66
ILE A 115
 IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 ( 4.3A)
IBI  A 201 ( 3.8A)
 0.83A 5pbeA-5vbrA:
17.2		 5pbeA-5vbrA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		4 / 6 VAL A  56
TYR A  66
ASN A 109
ILE A 115
 IBI  A 201 ( 4.6A)
IBI  A 201 ( 4.3A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.52A 5pbeA-5vbrA:
17.2		 5pbeA-5vbrA:
26.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens) 		8 / 8 PRO A  51
VAL A  56
LEU A  61
LEU A  63
CYH A 105
TYR A 108
ASN A 109
ILE A 115
 IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 ( 4.0A)
IBI  A 201 ( 4.5A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.56A 5y1yA-5vbrA:
19.2		 5y1yA-5vbrA:
64.52