SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IB2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O1C_A_ADNA127_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	1fhi	FRAGILE HISTIDINE TRIAD PROTEIN (Homo sapiens)	5 / 10	PHE A 5 ILE A 10 LEU A 37 HIS A 96 HIS A 98	IB2 A 301 (-4.6A) IB2 A 301 (-4.8A) IB2 A 301 (-4.6A) IB2 A 301 ( 3.9A) IB2 A 301 ( 3.2A)	0.57A	3o1cA-1fhiA: 10.5	3o1cA-1fhiA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O1X_A_ADNA1450_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	1fhi	FRAGILE HISTIDINE TRIAD PROTEIN (Homo sapiens)	5 / 10	PHE A 5 ILE A 10 LEU A 37 HIS A 96 HIS A 98	IB2 A 301 (-4.6A) IB2 A 301 (-4.8A) IB2 A 301 (-4.6A) IB2 A 301 ( 3.9A) IB2 A 301 ( 3.2A)	0.56A	3o1xA-1fhiA: 10.5	3o1xA-1fhiA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QGZ_A_ADNA127_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	1fhi	FRAGILE HISTIDINE TRIAD PROTEIN (Homo sapiens)	5 / 10	PHE A 5 ILE A 10 LEU A 37 HIS A 96 HIS A 98	IB2 A 301 (-4.6A) IB2 A 301 (-4.8A) IB2 A 301 (-4.6A) IB2 A 301 ( 3.9A) IB2 A 301 ( 3.2A)	0.57A	3qgzA-1fhiA: 10.5	3qgzA-1fhiA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KM9_B_ADNB201_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL)	1fhi	FRAGILE HISTIDINE TRIAD PROTEIN (Homo sapiens)	6 / 12	PHE A 5 ILE A 10 LEU A 37 VAL A 92 HIS A 96 HIS A 98	IB2 A 301 (-4.6A) IB2 A 301 (-4.8A) IB2 A 301 (-4.6A) IB2 A 301 (-4.5A) IB2 A 301 ( 3.9A) IB2 A 301 ( 3.2A)	0.47A	5km9B-1fhiA: 11.1	5km9B-1fhiA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UVM_B_ADNB207_1 (HISTIDINE TRIAD (HIT) PROTEIN)	1fhi	FRAGILE HISTIDINE TRIAD PROTEIN (Homo sapiens)	7 / 12	PHE A 5 ILE A 10 LEU A 37 THR A 91 VAL A 92 HIS A 96 HIS A 98	IB2 A 301 (-4.6A) IB2 A 301 (-4.8A) IB2 A 301 (-4.6A) IB2 A 301 (-2.9A) IB2 A 301 (-4.5A) IB2 A 301 ( 3.9A) IB2 A 301 ( 3.2A)	0.46A	5uvmB-1fhiA: 10.9	5uvmB-1fhiA: 23.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3O1C_A_ADNA127_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1","1fhi","FRAGILE HISTIDINE TRIAD PROTEIN","Homo sapiens",5,"PHE A   5;ILE A  10;LEU A  37;HIS A  96;HIS A  98","IB2 A 301 (-4.6A);IB2 A 301 (-4.8A);IB2 A 301 (-4.6A);IB2 A 301 ( 3.9A);IB2 A 301 ( 3.2A)","0.57A","3o1cA-1fhiA:10.5",null],["3O1X_A_ADNA1450_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1","1fhi","FRAGILE HISTIDINE TRIAD PROTEIN","Homo sapiens",5,"PHE A   5;ILE A  10;LEU A  37;HIS A  96;HIS A  98","IB2 A 301 (-4.6A);IB2 A 301 (-4.8A);IB2 A 301 (-4.6A);IB2 A 301 ( 3.9A);IB2 A 301 ( 3.2A)","0.56A","3o1xA-1fhiA:10.5","3o1cA-1fhiA:20.96"],["3QGZ_A_ADNA127_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1","1fhi","FRAGILE HISTIDINE TRIAD PROTEIN","Homo sapiens",5,"PHE A   5;ILE A  10;LEU A  37;HIS A  96;HIS A  98","IB2 A 301 (-4.6A);IB2 A 301 (-4.8A);IB2 A 301 (-4.6A);IB2 A 301 ( 3.9A);IB2 A 301 ( 3.2A)","0.57A","3qgzA-1fhiA:10.5","3o1xA-1fhiA:20.36"],["5KM9_B_ADNB201_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL","1fhi","FRAGILE HISTIDINE TRIAD PROTEIN","Homo sapiens",6,"PHE A   5;ILE A  10;LEU A  37;VAL A  92;HIS A  96;HIS A  98","IB2 A 301 (-4.6A);IB2 A 301 (-4.8A);IB2 A 301 (-4.6A);IB2 A 301 (-4.5A);IB2 A 301 ( 3.9A);IB2 A 301 ( 3.2A)","0.47A","5km9B-1fhiA:11.1","3qgzA-1fhiA:20.36"],["5UVM_B_ADNB207_1","HISTIDINE TRIAD (HIT) PROTEIN","1fhi","FRAGILE HISTIDINE TRIAD PROTEIN","Homo sapiens",7,"PHE A   5;ILE A  10;LEU A  37;THR A  91;VAL A  92;HIS A  96;HIS A  98","IB2 A 301 (-4.6A);IB2 A 301 (-4.8A);IB2 A 301 (-4.6A);IB2 A 301 (-2.9A);IB2 A 301 (-4.5A);IB2 A 301 ( 3.9A);IB2 A 301 ( 3.2A)","0.46A","5uvmB-1fhiA:10.9","5km9B-1fhiA:20.00"]]