SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IAC'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 10 LEU A  25
ALA A 339
VAL A 140
MET A 366
LEU A 349
None
IAC  A 702 (-4.5A)
None
None
None
1.41A 1aqbA-5kodA:
undetectable
1aqbA-5kodA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 12 SER A 272
ALA A 450
GLY A 451
LEU A 429
PHE A 467
None
None
None
NAD  A 700 (-4.5A)
IAC  A 701 (-4.5A)
1.28A 1vpoH-5iuwA:
undetectable
1vpoL-5iuwA:
undetectable
1vpoH-5iuwA:
17.35
1vpoL-5iuwA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
None
None
None
IAC  A 702 (-4.6A)
None
1.27A 3wg7A-5kodA:
2.3
3wg7B-5kodA:
undetectable
3wg7T-5kodA:
undetectable
3wg7A-5kodA:
20.72
3wg7B-5kodA:
17.51
3wg7T-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 12 PRO A 166
TYR A 487
VAL A 161
ALA A 174
MET A 172
NAD  A 700 (-4.2A)
None
None
None
IAC  A 701 ( 3.8A)
1.48A 4a84A-5iuwA:
undetectable
4a84A-5iuwA:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
6 / 11 ASN A 168
PHE A 169
MET A 173
TRP A 176
CYH A 302
ASP A 459
NAD  A 700 ( 3.0A)
IAC  A 701 (-3.7A)
NAD  A 700 (-3.9A)
None
IAC  A 701 ( 2.8A)
IAC  A 701 (-3.0A)
1.10A 4fr8A-5iuwA:
57.8
4fr8A-5iuwA:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 12 PHE A 467
TYR A 458
GLY A 468
SER A 473
SER A 306
IAC  A 701 (-4.5A)
None
None
None
None
1.44A 4ot2A-5iuwA:
undetectable
4ot2A-5iuwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 12 PHE A 467
TYR A 458
GLY A 468
SER A 473
SER A 306
IAC  A 701 (-4.5A)
None
None
None
None
1.45A 4zbrA-5iuwA:
undetectable
4zbrA-5iuwA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
7 / 12 GLY A 123
ASN A 168
PHE A 169
MET A 173
TRP A 176
CYH A 302
THR A 303
None
NAD  A 700 ( 3.0A)
IAC  A 701 (-3.7A)
NAD  A 700 (-3.9A)
None
IAC  A 701 ( 2.8A)
IAC  A 701 ( 4.2A)
0.61A 5fhzA-5iuwA:
56.4
5fhzA-5iuwA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 12 GLY A 124
ASN A 168
PHE A 169
TRP A 176
CYH A 302
None
NAD  A 700 ( 3.0A)
IAC  A 701 (-3.7A)
None
IAC  A 701 ( 2.8A)
1.11A 5fhzA-5iuwA:
56.4
5fhzA-5iuwA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
6 / 12 GLY A 123
ASN A 168
MET A 173
TRP A 176
CYH A 302
THR A 303
None
NAD  A 700 ( 3.0A)
NAD  A 700 (-3.9A)
None
IAC  A 701 ( 2.8A)
IAC  A 701 ( 4.2A)
0.63A 5fhzD-5iuwA:
56.7
5fhzD-5iuwA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
None
None
None
IAC  A 702 (-4.6A)
None
1.33A 5x19A-5kodA:
0.1
5x19B-5kodA:
undetectable
5x19T-5kodA:
undetectable
5x19A-5kodA:
20.72
5x19B-5kodA:
17.51
5x19T-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
None
None
None
IAC  A 702 (-4.6A)
None
1.27A 5xdqA-5kodA:
0.5
5xdqB-5kodA:
undetectable
5xdqT-5kodA:
undetectable
5xdqA-5kodA:
20.72
5xdqB-5kodA:
17.51
5xdqT-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
None
None
None
IAC  A 702 (-4.6A)
None
1.29A 5zcoA-5kodA:
1.3
5zcoB-5kodA:
undetectable
5zcoT-5kodA:
undetectable
5zcoA-5kodA:
20.72
5zcoB-5kodA:
17.51
5zcoT-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
None
None
None
IAC  A 702 (-4.6A)
None
1.32A 5zcpA-5kodA:
2.2
5zcpB-5kodA:
undetectable
5zcpT-5kodA:
undetectable
5zcpA-5kodA:
20.72
5zcpB-5kodA:
17.51
5zcpT-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 12 PHE A 467
TYR A 458
GLY A 468
SER A 473
SER A 306
IAC  A 701 (-4.5A)
None
None
None
None
1.40A 6ci6A-5iuwA:
undetectable
6ci6A-5iuwA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
4 / 8 GLY A 270
SER A 272
ASN A 168
VAL A 301
None
None
NAD  A 700 ( 3.0A)
IAC  A 701 ( 4.1A)
0.94A 6giqL-5iuwA:
undetectable
6giqP-5iuwA:
undetectable
6giqT-5iuwA:
undetectable
6giqL-5iuwA:
23.67
6giqP-5iuwA:
17.69
6giqT-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
4 / 8 MET A 173
GLY A 270
SER A 272
VAL A 301
NAD  A 700 (-3.9A)
None
None
IAC  A 701 ( 4.1A)
1.08A 6giqL-5iuwA:
undetectable
6giqP-5iuwA:
undetectable
6giqT-5iuwA:
undetectable
6giqL-5iuwA:
23.67
6giqP-5iuwA:
17.69
6giqT-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 11 GLY A 270
SER A 272
ALA A 431
ASN A 168
VAL A 301
None
None
None
NAD  A 700 ( 3.0A)
IAC  A 701 ( 4.1A)
1.24A 6hu9A-5iuwA:
1.0
6hu9E-5iuwA:
undetectable
6hu9I-5iuwA:
undetectable
6hu9A-5iuwA:
23.30
6hu9E-5iuwA:
15.97
6hu9I-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 11 MET A 173
GLY A 270
SER A 272
ALA A 431
VAL A 301
NAD  A 700 (-3.9A)
None
None
None
IAC  A 701 ( 4.1A)
1.42A 6hu9A-5iuwA:
1.0
6hu9E-5iuwA:
undetectable
6hu9I-5iuwA:
undetectable
6hu9A-5iuwA:
23.30
6hu9E-5iuwA:
15.97
6hu9I-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 10 GLY A 270
SER A 272
ALA A 431
ASN A 168
VAL A 301
None
None
None
NAD  A 700 ( 3.0A)
IAC  A 701 ( 4.1A)
1.18A 6hu9L-5iuwA:
undetectable
6hu9P-5iuwA:
undetectable
6hu9T-5iuwA:
undetectable
6hu9L-5iuwA:
23.30
6hu9P-5iuwA:
15.97
6hu9T-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae
group
genomosp.
3)
5 / 10 MET A 173
GLY A 270
SER A 272
ALA A 431
VAL A 301
NAD  A 700 (-3.9A)
None
None
None
IAC  A 701 ( 4.1A)
1.41A 6hu9L-5iuwA:
undetectable
6hu9P-5iuwA:
undetectable
6hu9T-5iuwA:
undetectable
6hu9L-5iuwA:
23.30
6hu9P-5iuwA:
15.97
6hu9T-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana)
5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
None
None
None
IAC  A 702 (-4.6A)
None
1.32A 6nknA-5kodA:
0.1
6nknB-5kodA:
undetectable
6nknT-5kodA:
undetectable
6nknA-5kodA:
20.72
6nknB-5kodA:
17.51
6nknT-5kodA:
9.60