SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'I24'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.02A 1c9sP-2vvtA:
undetectable
1c9sQ-2vvtA:
undetectable		 1c9sP-2vvtA:
12.76
1c9sQ-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.11A 1gtfJ-2vvtA:
undetectable
1gtfK-2vvtA:
undetectable		 1gtfJ-2vvtA:
12.76
1gtfK-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.02A 1gtfQ-2vvtA:
undetectable
1gtfR-2vvtA:
undetectable		 1gtfQ-2vvtA:
12.76
1gtfR-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.03A 1gtfS-2vvtA:
undetectable
1gtfT-2vvtA:
undetectable		 1gtfS-2vvtA:
12.76
1gtfT-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.05A 1gtnT-2vvtA:
undetectable
1gtnU-2vvtA:
undetectable		 1gtnT-2vvtA:
12.76
1gtnU-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.07A 1utdE-2vvtA:
undetectable
1utdF-2vvtA:
undetectable		 1utdE-2vvtA:
12.76
1utdF-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.07A 1utdH-2vvtA:
undetectable
1utdI-2vvtA:
undetectable		 1utdH-2vvtA:
12.76
1utdI-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 HIS A 187
THR A 121
THR A 118
GLY A 184
THR A 186
 I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 1.04A 1utdS-2vvtA:
undetectable
1utdT-2vvtA:
undetectable		 1utdS-2vvtA:
12.76
1utdT-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.06A 1utdL-2vvtA:
undetectable
1utdV-2vvtA:
undetectable		 1utdL-2vvtA:
12.76
1utdV-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 11 HIS A 236
PHE A 238
PHE A 247
GLY A  16
GLY A  15
 None
None
None
None
I24  A1269 ( 3.8A)
 1.35A 4fglA-2vvtA:
undetectable
4fglB-2vvtA:
undetectable		 4fglA-2vvtA:
20.45
4fglB-2vvtA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		4 / 5 GLY A  15
ASP A  11
GLU A  22
VAL A 216
 I24  A1269 ( 3.8A)
DGL  A1270 (-3.4A)
None
None
 0.95A 4nkvD-2vvtA:
undetectable		 4nkvD-2vvtA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5eevA-2vvtA:
undetectable
5eevB-2vvtA:
undetectable		 5eevA-2vvtA:
12.76
5eevB-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5eewA-2vvtA:
undetectable
5eewB-2vvtA:
undetectable		 5eewA-2vvtA:
12.76
5eewB-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5eexA-2vvtA:
undetectable
5eexB-2vvtA:
undetectable		 5eexA-2vvtA:
12.76
5eexB-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5eeyA-2vvtA:
undetectable
5eeyB-2vvtA:
undetectable		 5eeyA-2vvtA:
12.76
5eeyB-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5eezA-2vvtA:
undetectable
5eezB-2vvtA:
undetectable		 5eezA-2vvtA:
12.76
5eezB-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5ef0A-2vvtA:
undetectable
5ef0B-2vvtA:
undetectable		 5ef0A-2vvtA:
12.76
5ef0B-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5ef1A-2vvtA:
undetectable
5ef1B-2vvtA:
undetectable		 5ef1A-2vvtA:
12.76
5ef1B-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5ef2A-2vvtA:
undetectable
5ef2B-2vvtA:
undetectable		 5ef2A-2vvtA:
12.76
5ef2B-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2vvt GLUTAMATE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 184
THR A 186
HIS A 187
THR A 121
THR A 118
 None
DGL  A1270 (-3.0A)
I24  A1269 (-3.9A)
None
DGL  A1270 (-3.6A)
 1.10A 5ef3A-2vvtA:
undetectable
5ef3B-2vvtA:
undetectable		 5ef3A-2vvtA:
12.76
5ef3B-2vvtA:
12.76