SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HYM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		9 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
GLU A  91
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 ( 4.7A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.49A 1fmoE-1zltA:
26.6		 1fmoE-1zltA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
 0.70A 1m17A-1zltA:
23.4		 1m17A-1zltA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 9 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.71A 1muoA-1zltA:
7.0		 1muoA-1zltA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
VAL A  68
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
 0.74A 1opjA-1zltA:
20.9		 1opjA-1zltA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.57A 1t46A-1zltA:
21.0		 1t46A-1zltA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
 0.52A 1uwhA-1zltA:
13.3		 1uwhA-1zltA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
None
None
 0.64A 1uwhB-1zltA:
8.5		 1uwhB-1zltA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
 0.58A 1uwjA-1zltA:
6.8		 1uwjA-1zltA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
 0.57A 1uwjB-1zltA:
21.2		 1uwjB-1zltA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		3 / 3 LYS A  38
ASP A 130
CYH A 168
 HYM  A 400 (-3.2A)
None
None
 1.50A 2br4F-1zltA:
undetectable		 2br4F-1zltA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
ASP A 130
LYS A 132
ASN A 135
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
 0.82A 2fumA-1zltA:
4.0		 2fumA-1zltA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
LYS A 132
ASN A 135
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
 0.69A 2fumB-1zltA:
25.3		 2fumB-1zltA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
ASN A 135
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
 0.47A 2fumC-1zltA:
23.1		 2fumC-1zltA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
VAL A  68
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.61A 2gqgB-1zltA:
24.7		 2gqgB-1zltA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
 0.70A 2itoA-1zltA:
22.4		 2itoA-1zltA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
 0.81A 2ityA-1zltA:
22.2		 2ityA-1zltA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.78A 2ityA-1zltA:
22.2		 2ityA-1zltA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.79A 2itzA-1zltA:
16.4		 2itzA-1zltA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
LYS A  38
LEU A  82
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.64A 2ivuA-1zltA:
25.0		 2ivuA-1zltA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 GLY A  16
VAL A  23
ALA A  36
LEU A  84
TYR A  86
GLY A  90
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-3.9A)
 0.88A 2wgjA-1zltA:
21.1		 2wgjA-1zltA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 9 LEU A  15
VAL A  23
ALA A  36
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.83A 2xp2A-1zltA:
21.4		 2xp2A-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
SER A 147
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.76A 2y6oA-1zltA:
21.2		 2y6oA-1zltA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 8 LEU A  15
ALA A  36
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.79A 2yfxA-1zltA:
12.1		 2yfxA-1zltA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 LEU A 137
ILE A 146
LEU A 121
ILE A  58
VAL A  23
 HYM  A 400 (-4.5A)
None
None
None
HYM  A 400 (-4.3A)
 1.08A 2ygqA-1zltA:
undetectable		 2ygqA-1zltA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 10 LEU A  15
ALA A  36
LYS A  38
VAL A  68
LEU A  84
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.66A 3aoxA-1zltA:
20.9		 3aoxA-1zltA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
ALA A  36
LYS A  38
VAL A  68
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.61A 3c7qA-1zltA:
20.3		 3c7qA-1zltA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		9 / 12 LEU A  15
GLY A  16
GLY A  21
VAL A  23
ALA A  36
LYS A  38
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
None
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.68A 3eygA-1zltA:
25.2		 3eygA-1zltA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
 0.49A 3fupB-1zltA:
14.6		 3fupB-1zltA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.48A 3fupB-1zltA:
14.6		 3fupB-1zltA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 11 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.37A 3g0eA-1zltA:
19.6		 3g0eA-1zltA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 11 LEU A  15
VAL A  23
ALA A  36
TYR A  86
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.42A 3g0fA-1zltA:
20.7		 3g0fA-1zltA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 10 LEU A  15
VAL A  23
ALA A  36
TYR A  86
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.34A 3g0fB-1zltA:
13.1		 3g0fB-1zltA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.60A 3g5dA-1zltA:
16.6		 3g5dA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		9 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.78A 3g5dB-1zltA:
16.4		 3g5dB-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
VAL A  68
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
 0.69A 3gvuA-1zltA:
21.3		 3gvuA-1zltA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 ALA A  36
LYS A  38
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
SER A 147
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.72A 3k54A-1zltA:
21.3		 3k54A-1zltA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.71A 3k54A-1zltA:
21.3		 3k54A-1zltA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 8 ALA A  36
LYS A  38
GLU A  55
LEU A  82
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.28A 3lfaA-1zltA:
21.4		 3lfaA-1zltA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-3.9A)
 0.80A 3lxkA-1zltA:
24.8		 3lxkA-1zltA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
 0.58A 3lxkA-1zltA:
24.8		 3lxkA-1zltA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.59A 3octA-1zltA:
22.4		 3octA-1zltA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.74A 3og7A-1zltA:
22.0		 3og7A-1zltA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
VAL A  68
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
 0.69A 3pyyB-1zltA:
21.0		 3pyyB-1zltA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.80A 3qlgA-1zltA:
21.5		 3qlgA-1zltA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.72A 3qlgB-1zltA:
16.2		 3qlgB-1zltA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.53A 3sxrA-1zltA:
23.7		 3sxrA-1zltA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.52A 3sxrB-1zltA:
23.2		 3sxrB-1zltA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
GLY A  90
SER A 147
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-3.5A)
 0.68A 3sxrB-1zltA:
23.2		 3sxrB-1zltA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
VAL A  68
LEU A 137
SER A 147
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.79A 3v5wA-1zltA:
8.2		 3v5wA-1zltA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
 0.59A 3wzdA-1zltA:
20.9		 3wzdA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 5 ILE A  58
VAL A  68
LEU A 137
ASP A 148
 None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.90A 3wzdA-1zltA:
20.9		 3wzdA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 121
HIS A 128
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
None
 0.62A 3wzeA-1zltA:
20.7		 3wzeA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 8 VAL A  67
VAL A  68
CYH A  87
LEU A 137
ILE A 146
 None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
None
 0.49A 3wzeA-1zltA:
20.7		 3wzeA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 8 VAL A  67
VAL A  68
ILE A 146
ASP A 148
 None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-3.9A)
 0.49A 3wzeA-1zltA:
20.7		 3wzeA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A 121
HIS A 128
ARG A 129
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
 0.79A 3zosA-1zltA:
20.1		 3zosA-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 ALA A  36
LYS A  38
GLU A  55
LEU A 121
HIS A 128
ARG A 129
LEU A 137
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
 0.79A 3zosB-1zltA:
20.3		 3zosB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 9 LEU A  15
ILE A  58
LEU A  62
TYR A  86
ILE A 146
 HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-4.7A)
None
 0.73A 3zosB-1zltA:
20.3		 3zosB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.49A 4ag8A-1zltA:
20.9		 4ag8A-1zltA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
HYM  A 400 (-4.5A)
 0.50A 4agcA-1zltA:
20.5		 4agcA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 11 LEU A  15
ALA A  36
LYS A  38
VAL A  68
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.58A 4agdA-1zltA:
20.3		 4agdA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 9 LEU A  15
VAL A  23
ALA A  36
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.88A 4anqA-1zltA:
21.0		 4anqA-1zltA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 121
HIS A 128
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
None
 0.56A 4asdA-1zltA:
20.6		 4asdA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 6 VAL A  68
CYH A  87
LEU A 137
ILE A 146
 HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
None
 0.44A 4asdA-1zltA:
20.6		 4asdA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 5 LYS A  38
LEU A  62
TYR A  86
ARG A 129
 HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
 1.17A 4bkjB-1zltA:
20.2		 4bkjB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 11 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.74A 4ckiA-1zltA:
25.6		 4ckiA-1zltA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 10 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.50A 4ckjA-1zltA:
24.7		 4ckjA-1zltA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 VAL A  23
ALA A  36
GLU A  55
ILE A  58
VAL A  68
TYR A  86
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.83A 4csvA-1zltA:
16.1		 4csvA-1zltA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 8 ILE A  58
LYS A 132
ILE A 146
GLY A  18
 None
None
None
HYM  A 400 ( 3.7A)
 0.81A 4hdlA-1zltA:
undetectable		 4hdlA-1zltA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.91A 4hjoA-1zltA:
20.9		 4hjoA-1zltA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		9 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
LEU A  82
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.87A 4i22A-1zltA:
20.8		 4i22A-1zltA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 VAL A  23
ALA A  36
ASP A  94
ASP A 130
LYS A 132
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
None
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.59A 4i41A-1zltA:
27.6		 4i41A-1zltA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 11 VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLU A 134
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-3.9A)
 0.89A 4iaaA-1zltA:
27.4		 4iaaA-1zltA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  18
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.80A 4mkcA-1zltA:
21.6		 4mkcA-1zltA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.67A 4mkcA-1zltA:
21.6		 4mkcA-1zltA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.84A 4mxxB-1zltA:
14.9		 4mxxB-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.96A 4mxyA-1zltA:
16.7		 4mxyA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 VAL A  23
ALA A  36
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.87A 4mxyA-1zltA:
16.7		 4mxyA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.96A 4mxyB-1zltA:
22.8		 4mxyB-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.96A 4mxzA-1zltA:
16.7		 4mxzA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 VAL A  23
ALA A  36
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.87A 4mxzA-1zltA:
16.7		 4mxzA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.96A 4mxzB-1zltA:
22.8		 4mxzB-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 11 GLY A  16
VAL A  23
ALA A  36
LYS A  38
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.82A 4o0sA-1zltA:
21.3		 4o0sA-1zltA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 11 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
ASN A 135
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
 0.50A 4o0sA-1zltA:
21.3		 4o0sA-1zltA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 6 VAL A  23
ALA A  36
LYS A  38
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.5A)
 0.54A 4o0uA-1zltA:
7.3		 4o0uA-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.5A)
 0.35A 4o0wA-1zltA:
26.1		 4o0wA-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 8 GLY A  18
VAL A  23
ALA A  36
ASN A 135
ASP A 148
 HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
 0.59A 4ogrA-1zltA:
28.3		 4ogrA-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 8 VAL A  23
ALA A  36
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.55A 4ogrA-1zltA:
28.3		 4ogrA-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 7 GLY A  16
ALA A  36
CYH A  87
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.80A 4ogrE-1zltA:
27.0		 4ogrE-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 9 GLY A  18
VAL A  23
ALA A  36
CYH A  87
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.60A 4ogrI-1zltA:
28.2		 4ogrI-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
LYS A  38
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.70A 4otwA-1zltA:
20.5		 4otwA-1zltA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 VAL A  23
LYS A  38
VAL A  68
TYR A  86
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.77A 4otwA-1zltA:
20.5		 4otwA-1zltA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 11 ALA A  36
LYS A  38
GLU A  55
TYR A  86
LEU A 137
ASP A 148
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.71A 4qmsA-1zltA:
27.5		 4qmsA-1zltA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 8 LEU A  15
VAL A  23
HIS A 128
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
None
HYM  A 400 (-4.5A)
 0.53A 4qrcA-1zltA:
21.8		 4qrcA-1zltA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  87
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
 0.36A 4r7iA-1zltA:
14.2		 4r7iA-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 5 LEU A  15
VAL A  68
TYR A  86
ARG A 129
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
 0.64A 4r7iA-1zltA:
14.2		 4r7iA-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.80A 4rzvB-1zltA:
15.9		 4rzvB-1zltA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLY A  90
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.66A 4twpA-1zltA:
24.1		 4twpA-1zltA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 10 LEU A  15
VAL A  23
GLU A  55
LEU A  62
VAL A  68
TYR A  86
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
None
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
 0.89A 4u0iA-1zltA:
20.9		 4u0iA-1zltA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 10 LEU A  15
VAL A  23
LEU A  62
VAL A  68
TYR A  86
ARG A 129
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
None
 0.88A 4u0iA-1zltA:
20.9		 4u0iA-1zltA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
CYH A  87
GLY A  90
HIS A 128
LEU A 137
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-4.5A)
 0.49A 4u0iA-1zltA:
20.9		 4u0iA-1zltA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 11 LEU A  15
VAL A  23
ALA A  36
TYR A  86
GLY A  90
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.56A 4u5jA-1zltA:
12.8		 4u5jA-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 9 LEU A  15
VAL A  23
ALA A  36
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.63A 4u5jB-1zltA:
16.4		 4u5jB-1zltA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 LEU A  15
ALA A  36
LEU A 121
HIS A 128
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.5A)
 0.59A 4uxqA-1zltA:
21.4		 4uxqA-1zltA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 9 LEU A  15
VAL A  23
TYR A  86
ARG A 129
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
None
 0.55A 4v01A-1zltA:
21.1		 4v01A-1zltA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 9 LEU A  15
VAL A  23
LYS A  38
ILE A  58
TYR A  86
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
None
 1.30A 4v01B-1zltA:
21.4		 4v01B-1zltA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 9 LEU A  15
VAL A  23
LYS A  38
TYR A  86
ARG A 129
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
None
 0.79A 4v01B-1zltA:
21.4		 4v01B-1zltA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
TYR A  86
ARG A 129
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
None
 0.79A 4v04B-1zltA:
21.1		 4v04B-1zltA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 8 LEU A  15
ALA A  36
LEU A 137
SER A 147
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.49A 4wboB-1zltA:
24.6		 4wboB-1zltA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
ASP A  94
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
None
HYM  A 400 (-4.5A)
 0.80A 4wkqA-1zltA:
23.9		 4wkqA-1zltA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
VAL A  68
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.75A 4xeyA-1zltA:
24.1		 4xeyA-1zltA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.68A 4xliA-1zltA:
24.0		 4xliA-1zltA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.78A 4xliB-1zltA:
24.5		 4xliB-1zltA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  87
ASP A 148
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
None
 0.74A 4xv2A-1zltA:
15.3		 4xv2A-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 ALA A  36
LYS A  38
CYH A  87
ASP A 148
PHE A 149
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
None
 0.67A 4xv2B-1zltA:
14.5		 4xv2B-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 8 LEU A  15
GLY A  16
VAL A  23
ALA A  36
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
 0.81A 4zauA-1zltA:
23.1		 4zauA-1zltA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 9 LEU A  15
VAL A  23
ALA A  36
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.85A 5aaaA-1zltA:
21.3		 5aaaA-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 10 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.95A 5aabA-1zltA:
21.1		 5aabA-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 10 LEU A  15
VAL A  23
ALA A  36
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.85A 5aacA-1zltA:
21.2		 5aacA-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 10 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.85A 5aacA-1zltA:
21.2		 5aacA-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
ALA A  36
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.54A 5ajqA-1zltA:
22.2		 5ajqA-1zltA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 10 ALA A  36
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.34A 5ajqB-1zltA:
22.7		 5ajqB-1zltA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.57A 5bvwA-1zltA:
20.7		 5bvwA-1zltA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.59A 5cswA-1zltA:
22.0		 5cswA-1zltA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.64A 5cswB-1zltA:
12.0		 5cswB-1zltA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.81A 5h2uB-1zltA:
16.3		 5h2uB-1zltA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
TYR A  86
ASP A  94
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
None
 0.96A 5hesB-1zltA:
20.5		 5hesB-1zltA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
None
None
 0.69A 5hi2A-1zltA:
21.7		 5hi2A-1zltA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 GLY A  16
GLY A  18
VAL A  23
ALA A  36
LYS A  38
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-3.9A)
 0.84A 5hieC-1zltA:
14.6		 5hieC-1zltA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
TYR A  86
GLY A  90
LEU A 137
SER A 147
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.63A 5i9yA-1zltA:
21.0		 5i9yA-1zltA:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 11 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
LEU A  84
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.32A 5lvnA-1zltA:
21.2		 5lvnA-1zltA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 11 LEU A  15
VAL A  23
ALA A  36
VAL A  68
LEU A  84
TYR A  86
GLU A  91
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
HYM  A 400 ( 4.7A)
HYM  A 400 (-4.5A)
 0.42A 5lvnA-1zltA:
21.2		 5lvnA-1zltA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		9 / 12 GLY A  16
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  84
TYR A  86
GLY A  90
GLU A  91
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 ( 4.7A)
 0.65A 5mafA-1zltA:
27.5		 5mafA-1zltA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.66A 5n3hA-1zltA:
26.1		 5n3hA-1zltA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 8 ALA A  36
GLU A  55
CYH A  87
LEU A 137
ASP A 148
 HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.49A 5owrA-1zltA:
21.0		 5owrA-1zltA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  25
ALA A  36
GLU A  55
VAL A  68
GLY A  90
LEU A 137
 None
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-4.5A)
 0.49A 5te0A-1zltA:
24.7		 5te0A-1zltA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 ALA A  36
GLU A  55
TYR A  86
CYH A  87
GLY A  90
ASP A 148
 HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-3.9A)
 0.66A 5vc3A-1zltA:
24.9		 5vc3A-1zltA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 GLU A  55
TYR A  86
CYH A  87
GLY A  90
ASP A  94
ASP A 148
 None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-3.9A)
 0.88A 5vc3A-1zltA:
24.9		 5vc3A-1zltA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
ALA A  36
GLU A  55
VAL A  68
LEU A  82
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
None
None
 1.13A 5vcvA-1zltA:
25.5		 5vcvA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  89
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
 0.80A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
LEU A  82
CYH A  87
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.2A)
 0.58A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  89
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.92A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  82
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.69A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		5 / 9 LEU A  15
ALA A  36
VAL A  68
CYH A  87
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
None
 0.41A 5w5vA-1zltA:
14.1		 5w5vA-1zltA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.64A 5y7zA-1zltA:
23.8		 5y7zA-1zltA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.64A 5y7zA-1zltA:
23.8		 5y7zA-1zltA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
ALA A  36
GLU A  55
LEU A  82
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.77A 5y7zB-1zltA:
23.8		 5y7zB-1zltA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.55A 5y80A-1zltA:
23.1		 5y80A-1zltA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		4 / 8 LEU A  15
VAL A  23
LYS A  38
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
HYM  A 400 (-3.9A)
 0.80A 5y9mA-1zltA:
7.2		 5y9mA-1zltA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
LEU A  82
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
 0.58A 5yu9A-1zltA:
20.3		 5yu9A-1zltA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  82
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 1.05A 5yu9A-1zltA:
20.3		 5yu9A-1zltA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
TYR A  86
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
None
 0.44A 5zv2A-1zltA:
21.3		 5zv2A-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.49A 5zv2B-1zltA:
11.0		 5zv2B-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		3 / 3 TYR A  86
LEU A 137
ASP A 148
 HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.70A 5zv2B-1zltA:
15.3		 5zv2B-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens) 		7 / 12 VAL A  23
ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.60A 6bsdA-1zltA:
20.8		 6bsdA-1zltA:
15.14