SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HXA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  24
ILE A  28
ILE A 173
ALA A 133
LEU A 131
 None
HXA  A1215 ( 4.8A)
None
None
None
 1.16A 2m9qA-2byoA:
undetectable		 2m9qA-2byoA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 5 GLN A 122
THR A 259
LEU A 192
LEU A 157
 None
HXA  A9136 ( 3.7A)
None
None
 0.98A 4lvcB-2g7zA:
undetectable		 4lvcB-2g7zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 ILE A 263
ASP A  40
ARG A 172
 HXA  A9136 (-4.2A)
None
TRS  A5081 ( 3.6A)
 0.75A 4pstA-2g7zA:
undetectable		 4pstA-2g7zA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 THR A 267
HIS A  89
LEU A  29
 HXA  A9136 ( 4.2A)
None
None
 0.80A 5axdA-2g7zA:
2.1		 5axdA-2g7zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 THR A 267
HIS A  89
LEU A  29
 HXA  A9136 ( 4.2A)
None
None
 0.84A 5axdC-2g7zA:
2.1		 5axdC-2g7zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		5 / 12 GLY A 160
VAL A 188
ILE A 159
GLY A 170
GLY A 171
 None
None
HXA  A9136 ( 4.3A)
GOL  A2647 (-2.9A)
None
 0.95A 5koxA-2g7zA:
undetectable		 5koxA-2g7zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 4 GLN A 122
THR A 259
LEU A 192
LEU A 157
 None
HXA  A9136 ( 3.7A)
None
None
 0.98A 5m5kB-2g7zA:
undetectable		 5m5kB-2g7zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 7 THR A 259
PHE A  49
MET A  53
THR A  62
 HXA  A9136 ( 3.7A)
None
None
GOL  A2647 ( 3.3A)
 1.42A 5u6mA-2g7zA:
3.1		 5u6mA-2g7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 7 THR A 259
PHE A  49
MET A  53
THR A  62
 HXA  A9136 ( 3.7A)
None
None
GOL  A2647 ( 3.3A)
 1.44A 5u6mB-2g7zA:
2.2		 5u6mB-2g7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 5 ILE A 263
GLN A 122
THR A 259
LEU A 192
 HXA  A9136 (-4.2A)
None
HXA  A9136 ( 3.7A)
None
 0.97A 6f3mD-2g7zA:
undetectable		 6f3mD-2g7zA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 184
VAL A 171
ARG A 183
ASP A 140
 LNL  A1217 ( 4.1A)
HXA  A1215 ( 4.4A)
None
None
 0.99A 6hu9a-2byoA:
undetectable
6hu9e-2byoA:
undetectable		 6hu9a-2byoA:
19.35
6hu9e-2byoA:
23.76