SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HWG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1r20 ECDYSONE RECEPTOR
(Heliothis
virescens) 		4 / 6 ARG D 387
ASN D 400
ASN D 504
LEU D 522
 None
None
HWG  D2000 (-3.0A)
None
 1.26A 2nyrA-1r20D:
undetectable		 2nyrA-1r20D:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1r20 ECDYSONE RECEPTOR
(Heliothis
virescens) 		3 / 3 LEU D 421
MET D 381
TYR D 428
 None
HWG  D2000 ( 4.2A)
None
 0.70A 4p6xG-1r20D:
20.9		 4p6xG-1r20D:
24.16