SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HTA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 1os2A-1fblA:
28.0		 1os2A-1fblA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.45A 1os2D-1fblA:
28.0		 1os2D-1fblA:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.41A 1uttA-1fblA:
28.0		 1uttA-1fblA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.46A 1utzA-1fblA:
27.9		 1utzA-1fblA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.47A 1utzB-1fblA:
28.0		 1utzB-1fblA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 1y93A-1fblA:
27.7		 1y93A-1fblA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.41A 2hu6A-1fblA:
27.9		 2hu6A-1fblA:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 9 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.39A 2jihA-1fblA:
8.4		 2jihA-1fblA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 8 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.41A 2jihB-1fblA:
9.8		 2jihB-1fblA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.51A 2ow9A-1fblA:
27.6		 2ow9A-1fblA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.46A 2ow9B-1fblA:
27.5		 2ow9B-1fblA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.48A 2ozrC-1fblA:
27.8		 2ozrC-1fblA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 2ozrD-1fblA:
28.1		 2ozrD-1fblA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.34A 2ozrE-1fblA:
27.6		 2ozrE-1fblA:
29.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		3 / 3 HIS A 183
GLU A 219
HIS A 222
 ZN  A 997 (-3.2A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
 0.54A 3ba0A-1fblA:
31.4		 3ba0A-1fblA:
53.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 9 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 3hy7A-1fblA:
10.2		 3hy7A-1fblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 9 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.44A 3hy7B-1fblA:
10.1		 3hy7B-1fblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.41A 3kecA-1fblA:
27.6		 3kecA-1fblA:
29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.47A 3likA-1fblA:
27.8		 3likA-1fblA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.45A 3lilA-1fblA:
27.9		 3lilA-1fblA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.45A 3ljgA-1fblA:
28.1		 3ljgA-1fblA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.47A 3lkaA-1fblA:
27.8		 3lkaA-1fblA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.53A 4a7bA-1fblA:
27.8		 4a7bA-1fblA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
 0.40A 4a7bB-1fblA:
27.4		 4a7bB-1fblA:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		5 / 9 ASP A 194
ILE A 159
GLY A 193
GLY A 221
ARG A 214
 CA  A 995 (-3.3A)
None
CA  A 995 ( 4.9A)
None
HTA  A 900 ( 4.9A)
 1.27A 4acaB-1fblA:
undetectable
4acaC-1fblA:
undetectable		 4acaB-1fblA:
23.22
4acaC-1fblA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 5n5jA-1fblA:
27.9		 5n5jA-1fblA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.46A 5n5kA-1fblA:
27.4		 5n5kA-1fblA:
36.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)
(Sus
scrofa) 		4 / 9 PHE A 197
VAL A 215
HIS A 218
ASP A 209
 None
HTA  A 900 ( 4.0A)
ZN  A 998 ( 3.5A)
None
 0.92A 6c2mD-1fblA:
0.0		 6c2mD-1fblA:
12.50