SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HSM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		4 / 6 TYR A  21
GLY A  20
GLY A  17
SER A 109
 HSM  A 301 (-3.2A)
None
None
None
 0.94A 1eswA-3bu1A:
undetectable		 1eswA-3bu1A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 9 SER A  12
TYR A  21
VAL A  37
ASP A  94
TRP A 105
 HSM  A 301 (-3.6A)
HSM  A 301 (-3.2A)
None
HSM  A 301 (-2.9A)
HSM  A 301 (-3.3A)
 0.53A 1qftA-3bu1A:
16.9		 1qftA-3bu1A:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		7 / 9 SER A  20
TYR A  29
PHE A  98
TYR A 100
ASP A 120
ILE A 122
TRP A 137
 None
None
None
HSM  A 174 (-3.6A)
None
None
None
 0.55A 1qftA-3g7xA:
35.0		 1qftA-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		7 / 9 TYR A  29
VAL A  51
PHE A  98
TYR A 100
ASP A 120
ILE A 122
TRP A 137
 None
None
None
HSM  A 174 (-3.6A)
None
None
None
 0.22A 1qftA-3g7xA:
35.0		 1qftA-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFT_A_HSMA177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		10 / 10 TYR A  36
ASP A  39
VAL A  41
TRP A  42
GLU A  82
TYR A 100
PHE A 108
ASP A 110
VAL A 124
GLU A 135
 None
HSM  A 174 (-2.8A)
HSM  A 174 ( 4.3A)
HSM  A 174 (-3.7A)
HSM  A 174 (-2.8A)
HSM  A 174 (-3.6A)
HSM  A 174 (-4.0A)
HSM  A 174 (-3.2A)
HSM  A 174 (-4.4A)
HSM  A 174 (-3.4A)
 0.18A 1qftA-3g7xA:
35.0		 1qftA-3g7xA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 9 SER A  12
TYR A  21
VAL A  37
ASP A  94
TRP A 105
 HSM  A 301 (-3.6A)
HSM  A 301 (-3.2A)
None
HSM  A 301 (-2.9A)
HSM  A 301 (-3.3A)
 0.45A 1qftB-3bu1A:
17.5		 1qftB-3bu1A:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		7 / 9 SER A  20
TYR A  29
PHE A  98
TYR A 100
ASP A 120
ILE A 122
TRP A 137
 None
None
None
HSM  A 174 (-3.6A)
None
None
None
 0.54A 1qftB-3g7xA:
33.4		 1qftB-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		7 / 9 TYR A  29
VAL A  51
PHE A  98
TYR A 100
ASP A 120
ILE A 122
TRP A 137
 None
None
None
HSM  A 174 (-3.6A)
None
None
None
 0.24A 1qftB-3g7xA:
33.4		 1qftB-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFT_B_HSMB177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		10 / 10 TYR A  36
ASP A  39
VAL A  41
TRP A  42
GLU A  82
TYR A 100
PHE A 108
ASP A 110
VAL A 124
GLU A 135
 None
HSM  A 174 (-2.8A)
HSM  A 174 ( 4.3A)
HSM  A 174 (-3.7A)
HSM  A 174 (-2.8A)
HSM  A 174 (-3.6A)
HSM  A 174 (-4.0A)
HSM  A 174 (-3.2A)
HSM  A 174 (-4.4A)
HSM  A 174 (-3.4A)
 0.19A 1qftB-3g7xA:
33.4		 1qftB-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFV_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		10 / 10 TYR A  36
ASP A  39
VAL A  41
TRP A  42
GLU A  82
TYR A 100
PHE A 108
ASP A 110
VAL A 124
GLU A 135
 None
HSM  A 174 (-2.8A)
HSM  A 174 ( 4.3A)
HSM  A 174 (-3.7A)
HSM  A 174 (-2.8A)
HSM  A 174 (-3.6A)
HSM  A 174 (-4.0A)
HSM  A 174 (-3.2A)
HSM  A 174 (-4.4A)
HSM  A 174 (-3.4A)
 0.14A 1qfvA-3g7xA:
35.1		 1qfvA-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QFV_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		10 / 10 TYR A  36
ASP A  39
VAL A  41
TRP A  42
GLU A  82
TYR A 100
PHE A 108
ASP A 110
VAL A 124
GLU A 135
 None
HSM  A 174 (-2.8A)
HSM  A 174 ( 4.3A)
HSM  A 174 (-3.7A)
HSM  A 174 (-2.8A)
HSM  A 174 (-3.6A)
HSM  A 174 (-4.0A)
HSM  A 174 (-3.2A)
HSM  A 174 (-4.4A)
HSM  A 174 (-3.4A)
 0.21A 1qfvB-3g7xA:
33.3		 1qfvB-3g7xA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 6 ASP A  94
SER A  88
SER A   8
VAL A   7
GLY A  15
 HSM  A 301 (-2.9A)
None
None
None
None
 1.38A 1tnlA-3bu1A:
undetectable		 1tnlA-3bu1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 6 ASP A  94
SER A  88
SER A   8
VAL A   7
GLY A  15
 HSM  A 301 (-2.9A)
None
None
None
None
 1.43A 2otvA-3bu1A:
undetectable		 2otvA-3bu1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 8 ASP A  94
SER A  88
SER A   8
VAL A   7
GLY A  15
 HSM  A 301 (-2.9A)
None
None
None
None
 1.34A 2vinA-3bu1A:
undetectable		 2vinA-3bu1A:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		6 / 6 SER A  12
TYR A  21
VAL A  37
TYR A  51
ASP A  94
TRP A 105
 HSM  A 301 (-3.6A)
HSM  A 301 (-3.2A)
None
HSM  A 301 (-4.6A)
HSM  A 301 (-2.9A)
HSM  A 301 (-3.3A)
 0.30A 2x45A-3bu1A:
26.0		 2x45A-3bu1A:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 5 VAL A  37
TYR A  53
VAL A  78
ASP A  81
SER A  83
 None
None
None
None
HSM  A 301 ( 4.0A)
 0.48A 2x45A-3bu1A:
26.0		 2x45A-3bu1A:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		7 / 7 SER A  12
TYR A  21
VAL A  37
TYR A  51
ILE A  76
ASP A  94
TRP A 105
 HSM  A 301 (-3.6A)
HSM  A 301 (-3.2A)
None
HSM  A 301 (-4.6A)
HSM  A 301 ( 4.0A)
HSM  A 301 (-2.9A)
HSM  A 301 (-3.3A)
 0.34A 2x45B-3bu1A:
25.9		 2x45B-3bu1A:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		4 / 4 VAL A  37
TYR A  53
VAL A  78
SER A  83
 None
None
None
HSM  A 301 ( 4.0A)
 0.33A 2x45B-3bu1A:
25.9		 2x45B-3bu1A:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		7 / 7 SER A  12
TYR A  21
VAL A  37
TYR A  51
ILE A  76
ASP A  94
TRP A 105
 HSM  A 301 (-3.6A)
HSM  A 301 (-3.2A)
None
HSM  A 301 (-4.6A)
HSM  A 301 ( 4.0A)
HSM  A 301 (-2.9A)
HSM  A 301 (-3.3A)
 0.33A 2x45C-3bu1A:
25.9		 2x45C-3bu1A:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3bu1 LIPOCALIN
(Argas
monolakensis) 		5 / 5 VAL A  37
TYR A  53
VAL A  78
ASP A  81
SER A  83
 None
None
None
None
HSM  A 301 ( 4.0A)
 0.53A 2x45C-3bu1A:
25.9		 2x45C-3bu1A:
48.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		4 / 5 TRP A 137
PHE A 152
TYR A 134
VAL A 124
 None
None
None
HSM  A 174 (-4.4A)
 1.33A 2zbuB-3g7xA:
0.4		 2zbuB-3g7xA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2
(Rhipicephalus
appendiculatus) 		4 / 8 ASP A  39
PHE A  67
ILE A 122
TRP A 137
 HSM  A 174 (-2.8A)
None
None
None
 0.99A 5hw8H-3g7xA:
undetectable		 5hw8H-3g7xA:
19.21