SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HS8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 HIS A  93
HIS A 116
HIS A 256
ALA A 276
 CU  A 700 (-3.1A)
CU  A 700 (-3.2A)
HS8  A 252 ( 3.6A)
None
 0.60A 4p6sA-4z0zA:
20.7		 4p6sA-4z0zA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 PHE A 225
PHE A 121
PHE A 122
VAL A 247
 None
HS8  A 252 ( 4.6A)
None
None
 1.20A 5a1rA-4z0zA:
undetectable		 5a1rA-4z0zA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 HIS A  93
HIS A 116
HIS A 256
ALA A 276
 CU  A 700 (-3.1A)
CU  A 700 (-3.2A)
HS8  A 252 ( 3.6A)
None
 0.51A 5i3aA-4z0zA:
21.0		 5i3aA-4z0zA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 HIS A  93
HIS A 116
HIS A 256
ALA A 276
 CU  A 700 (-3.1A)
CU  A 700 (-3.2A)
HS8  A 252 ( 3.6A)
None
 0.46A 5i3aB-4z0zA:
20.9		 5i3aB-4z0zA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 HIS A  93
HIS A 116
HIS A 256
ALA A 276
 CU  A 700 (-3.1A)
CU  A 700 (-3.2A)
HS8  A 252 ( 3.6A)
None
 0.56A 5i3bA-4z0zA:
21.1		 5i3bA-4z0zA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
HIS A 116
HIS A 256
ALA A 276
 CU  A 700 (-3.1A)
CU  A 700 (-3.2A)
HS8  A 252 ( 3.6A)
None
 0.49A 5i3bB-4z0zA:
21.1		 5i3bB-4z0zA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.81A 5mhwA-4z0zA:
undetectable		 5mhwA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.80A 5mhxA-4z0zA:
undetectable		 5mhxA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.80A 5mhyA-4z0zA:
undetectable		 5mhyA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.80A 5mhzA-4z0zA:
undetectable		 5mhzA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.79A 5mi1A-4z0zA:
undetectable		 5mi1A-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.79A 5mi2A-4z0zA:
undetectable		 5mi2A-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.79A 5miaA-4z0zA:
undetectable		 5miaA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.79A 5mibA-4z0zA:
undetectable		 5mibA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.79A 5micA-4z0zA:
undetectable		 5micA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.79A 5midA-4z0zA:
undetectable		 5midA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.80A 5mieA-4z0zA:
undetectable		 5mieA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 256
PHE A 282
HIS A 285
HIS A 286
 HS8  A 252 ( 3.6A)
None
HS8  A 252 ( 4.1A)
HS8  A 252 ( 3.7A)
 0.63A 5zrdB-4z0zA:
3.1		 5zrdB-4z0zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4z0z AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 TYR A 128
HIS A 286
PHE A 282
 None
HS8  A 252 ( 3.7A)
None
 1.02A 6esmA-4z0zA:
undetectable		 6esmA-4z0zA:
13.02