SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HQE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 8 PHE A 197
HIS A 204
HIS A 231
HIS A 208
 None
ZN  A 302 ( 3.4A)
ZN  A 302 (-3.1A)
HQE  A 303 ( 3.0A)
 0.94A 1azmA-5i3aA:
undetectable		 1azmA-5i3aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 8 PHE A 197
HIS A 204
HIS A 208
HIS A  69
 None
ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 4.9A)
 0.97A 1bzmA-5i3aA:
undetectable		 1bzmA-5i3aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 8 PHE A 197
HIS A 204
HIS A 231
HIS A 208
 None
ZN  A 302 ( 3.4A)
ZN  A 302 (-3.1A)
HQE  A 303 ( 3.0A)
 0.92A 1bzmA-5i3aA:
undetectable		 1bzmA-5i3aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 7 TYR A  72
HIS A  42
HIS A 208
TRP A  68
 None
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
None
 1.45A 1yvmA-5i3aA:
undetectable		 1yvmA-5i3aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 5 HIS A 204
HIS A 208
VAL A 234
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
None
ZN  A 302 (-3.1A)
 1.02A 2wkoF-5i3aA:
undetectable		 2wkoF-5i3aA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii) 		4 / 6 ARG C 402
ARG C 388
ILE C 350
TYR C 406
 None
SO4  C1588 ( 3.9A)
HQE  C1583 ( 4.9A)
None
 1.15A 2yfbB-5fseC:
undetectable		 2yfbB-5fseC:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  60
HIS A  42
HIS A 208
HIS A 204
ASP A 235
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 3.4A)
None
 1.50A 2zweA-5i3aA:
39.4
2zweB-5i3aA:
undetectable		 2zweA-5i3aA:
43.84
2zweB-5i3aA:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.32A 2zwfA-5i3aA:
39.5
2zwfB-5i3aA:
undetectable		 2zwfA-5i3aA:
43.84
2zwfB-5i3aA:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  60
HIS A  42
HIS A 208
HIS A 204
ASP A 235
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 3.4A)
None
 1.46A 2zwfA-5i3aA:
39.5
2zwfB-5i3aA:
undetectable		 2zwfA-5i3aA:
43.84
2zwfB-5i3aA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 12 HIS A 208
HIS A 204
HIS A  60
PHE A  65
PRO A 268
 HQE  A 303 ( 3.0A)
ZN  A 302 ( 3.4A)
ZN  A 301 ( 3.2A)
None
None
 1.33A 4bz6A-5i3aA:
undetectable
4bz6B-5i3aA:
undetectable		 4bz6A-5i3aA:
18.16
4bz6B-5i3aA:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6S_A_DAHA305_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		7 / 7 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
ALA A 221
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
HQE  A 303 (-3.3A)
 0.15A 4p6sA-5i3aA:
50.8		 4p6sA-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6S_A_DAHA305_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 7 HIS A  60
HIS A 231
HIS A 208
VAL A 218
ALA A 221
 ZN  A 301 ( 3.2A)
ZN  A 302 (-3.1A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
HQE  A 303 (-3.3A)
 1.36A 4p6sA-5i3aA:
50.8		 4p6sA-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6S_A_DAHA305_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 7 HIS A 208
HIS A 231
HIS A  42
ALA A 221
 HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
ZN  A 301 ( 3.2A)
HQE  A 303 (-3.3A)
 0.62A 4p6sA-5i3aA:
50.8		 4p6sA-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6S_B_DAHB305_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		6 / 7 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
 0.21A 4p6sB-5i3aA:
50.8		 4p6sB-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6S_B_DAHB305_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		6 / 7 HIS A  42
HIS A  60
HIS A 204
HIS A 208
ARG A 209
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
None
HQE  A 303 (-3.3A)
 1.10A 4p6sB-5i3aA:
50.8		 4p6sB-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3B_A_HQEA303_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		7 / 7 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
ALA A 221
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
HQE  A 303 (-3.3A)
 0.11A 5i3bA-5i3aA:
52.5		 5i3bA-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3B_A_HQEA303_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 7 HIS A  60
HIS A 231
HIS A 208
VAL A 218
ALA A 221
 ZN  A 301 ( 3.2A)
ZN  A 302 (-3.1A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
HQE  A 303 (-3.3A)
 1.39A 5i3bA-5i3aA:
52.5		 5i3bA-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3B_A_HQEA303_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 7 HIS A 208
HIS A 231
HIS A  42
ALA A 221
 HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
ZN  A 301 ( 3.2A)
HQE  A 303 (-3.3A)
 0.68A 5i3bA-5i3aA:
52.5		 5i3bA-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3B_B_HQEB303_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 5 HIS A  42
HIS A  60
HIS A 208
VAL A 218
ALA A 221
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
HQE  A 303 (-3.3A)
 0.18A 5i3bB-5i3aA:
52.2		 5i3bB-5i3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3B_B_HQEB303_1
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 5 HIS A 208
HIS A 231
HIS A  42
ALA A 221
 HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
ZN  A 301 ( 3.2A)
HQE  A 303 (-3.3A)
 0.71A 5i3bB-5i3aA:
52.2		 5i3bB-5i3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 10 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.25A 5m8nA-5i3aA:
33.5		 5m8nA-5i3aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 10 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.18A 5m8nB-5i3aA:
33.3		 5m8nB-5i3aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 9 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.22A 5m8nC-5i3aA:
33.0		 5m8nC-5i3aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 7 HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
 0.15A 5m8rA-5i3aA:
33.4		 5m8rA-5i3aA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 8 HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
 0.21A 5m8rB-5i3aA:
33.4		 5m8rB-5i3aA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		6 / 8 HIS A  60
HIS A 204
ASN A 205
HIS A 208
GLY A 216
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
None
HQE  A 303 (-3.3A)
 0.22A 5m8rC-5i3aA:
33.4		 5m8rC-5i3aA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 8 HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
 0.23A 5m8rD-5i3aA:
33.4		 5m8rD-5i3aA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.41A 5z0fA-5i3aA:
39.5
5z0fB-5i3aA:
undetectable		 5z0fA-5i3aA:
22.40
5z0fB-5i3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  60
HIS A  42
HIS A 208
HIS A 204
ASP A 235
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 3.4A)
None
 1.48A 5z0jA-5i3aA:
39.5
5z0jB-5i3aA:
undetectable		 5z0jA-5i3aA:
22.40
5z0jB-5i3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.35A 5z0kA-5i3aA:
39.5
5z0kB-5i3aA:
undetectable		 5z0kA-5i3aA:
22.40
5z0kB-5i3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  60
HIS A  42
HIS A 208
HIS A 204
ASP A 235
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 3.4A)
None
 1.47A 5z0kA-5i3aA:
39.5
5z0kB-5i3aA:
undetectable		 5z0kA-5i3aA:
22.40
5z0kB-5i3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 11 HIS A  42
HIS A  60
HIS A 204
ASN A 205
HIS A 208
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
 0.38A 5z0lA-5i3aA:
39.4
5z0lB-5i3aA:
undetectable		 5z0lA-5i3aA:
22.40
5z0lB-5i3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		3 / 3 HIS A 204
HIS A 208
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
 0.14A 5zrdA-5i3aA:
3.4		 5zrdA-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 5 HIS A 204
HIS A 208
PHE A 227
HIS A 230
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 4.7A)
None
ZN  A 302 (-3.1A)
 0.18A 5zrdB-5i3aA:
4.0		 5zrdB-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 5 HIS A 204
HIS A 208
HIS A 231
PHE A  65
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
None
 0.97A 5zrdB-5i3aA:
4.0		 5zrdB-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 4 HIS A 204
HIS A 208
HIS A 230
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
None
ZN  A 302 (-3.1A)
 0.16A 5zrdC-5i3aA:
undetectable		 5zrdC-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 5 HIS A 204
HIS A 208
HIS A 231
PHE A  65
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
None
 1.01A 5zrdC-5i3aA:
3.6		 5zrdC-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 5 HIS A 204
HIS A 208
HIS A 231
PHE A  65
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
None
 0.97A 5zrdD-5i3aA:
5.0		 5zrdD-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		4 / 4 HIS A 204
HIS A 208
HIS A 230
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
None
ZN  A 302 (-3.1A)
 0.17A 5zrdD-5i3aA:
5.0		 5zrdD-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 12 GLN A 193
HIS A 231
ASN A 205
GLY A 196
PHE A 190
 None
ZN  A 302 (-3.1A)
HQE  A 303 (-3.4A)
None
None
 1.19A 6exiA-5i3aA:
undetectable		 6exiA-5i3aA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 12 GLN A 193
HIS A  69
ASN A 205
GLY A 196
PHE A 190
 None
ZN  A 302 ( 4.9A)
HQE  A 303 (-3.4A)
None
None
 1.32A 6exiD-5i3aA:
undetectable		 6exiD-5i3aA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5i3a TYROSINASE
(Bacillus
megaterium) 		5 / 12 GLN A 193
HIS A 231
ASN A 205
GLY A 196
PHE A 190
 None
ZN  A 302 (-3.1A)
HQE  A 303 (-3.4A)
None
None
 1.21A 6exiD-5i3aA:
undetectable		 6exiD-5i3aA:
14.29