SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HPX'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1D4F_C_ADNC603_1 (S-ADENOSYLHOMOCYSTEINE HYDROLASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 12 | HIS A 249THR A 252LEU A 303HIS A 217PHE A 270 | HPX A 406 (-3.4A)HPX A 406 ( 3.8A)None FE A 400 ( 3.4A)None | 1.46A | 1d4fC-3lm4A:undetectable | 1d4fC-3lm4A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NKI_A_PPFA5001_1 (PROBABLE FOSFOMYCINRESISTANCE PROTEIN) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 9 | HIS A 217SER A 254TYR A 258GLU A 268HIS A 155 | FE A 400 ( 3.4A)HPX A 406 ( 4.5A)None FE A 400 (-2.7A) FE A 400 ( 3.5A) | 1.23A | 1nkiA-3lm4A:8.61nkiB-3lm4A:8.5 | 1nkiA-3lm4A:18.151nkiB-3lm4A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NKI_B_PPFB5002_1 (PROBABLE FOSFOMYCINRESISTANCE PROTEIN) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 9 | HIS A 155HIS A 217SER A 254TYR A 258GLU A 268 | FE A 400 ( 3.5A) FE A 400 ( 3.4A)HPX A 406 ( 4.5A)None FE A 400 (-2.7A) | 1.24A | 1nkiA-3lm4A:8.61nkiB-3lm4A:8.5 | 1nkiA-3lm4A:18.151nkiB-3lm4A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XCT_X_CPFX1020_1 (DNA GYRASE SUBUNITB, DNA GYRASESUBUNIT A) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 4 / 4 | ARG A 181GLY A 190GLU A 188SER A 254 | NoneNoneNoneHPX A 406 ( 4.5A) | 1.24A | 2xctS-3lm4A:undetectable2xctU-3lm4A:undetectable | 2xctS-3lm4A:20.432xctU-3lm4A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2YLG_A_ASCA130_0 (CYTOCHROME C') |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 4 / 5 | ALA A 244GLY A 299LYS A 248HIS A 249 | NoneNoneNoneHPX A 406 (-3.4A) | 1.42A | 2ylgA-3lm4A:undetectable | 2ylgA-3lm4A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZWE_B_DAHB98_1 (TYROSINASEMELC) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.24A | 2zweA-3lm4A:undetectable2zweB-3lm4A:undetectable | 2zweA-3lm4A:22.542zweB-3lm4A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZWF_B_DAHB98_1 (TYROSINASEMELC) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.23A | 2zwfA-3lm4A:undetectable2zwfB-3lm4A:undetectable | 2zwfA-3lm4A:22.542zwfB-3lm4A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZWG_B_DAHB98_1 (TYROSINASEMELC) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.24A | 2zwgA-3lm4A:undetectable2zwgB-3lm4A:undetectable | 2zwgA-3lm4A:22.542zwgB-3lm4A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O8F_B_BRLB501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 12 | HIS A 155VAL A 182MET A 289MET A 205HIS A 217 | FE A 400 ( 3.5A)NoneHPX A 406 ( 4.6A)HPX A 406 (-3.5A) FE A 400 ( 3.4A) | 1.45A | 4o8fB-3lm4A:undetectable | 4o8fB-3lm4A:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O8F_B_BRLB501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 12 | SER A 254HIS A 155VAL A 182MET A 289HIS A 217 | HPX A 406 ( 4.5A) FE A 400 ( 3.5A)NoneHPX A 406 ( 4.6A) FE A 400 ( 3.4A) | 1.41A | 4o8fB-3lm4A:undetectable | 4o8fB-3lm4A:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PFJ_B_ADNB502_1 (ADENOSYLHOMOCYSTEINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 12 | HIS A 249THR A 252LEU A 303HIS A 217PHE A 270 | HPX A 406 (-3.4A)HPX A 406 ( 3.8A)None FE A 400 ( 3.4A)None | 1.42A | 4pfjB-3lm4A:undetectable | 4pfjB-3lm4A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RVG_A_SAMA503_0 (D-MYCAROSE3-C-METHYLTRANSFERASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 12 | THR A 178ILE A 189GLY A 190VAL A 182ILE A 292 | NoneHPX A 406 (-4.1A)NoneNoneNone | 1.00A | 4rvgA-3lm4A:undetectable | 4rvgA-3lm4A:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5JLI_A_ASCA202_0 (CYTOCHROME C') |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 4 / 5 | ALA A 244GLY A 299LYS A 248HIS A 249 | NoneNoneNoneHPX A 406 (-3.4A) | 1.47A | 5jliA-3lm4A:undetectable | 5jliA-3lm4A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0F_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.20A | 5z0fA-3lm4A:undetectable5z0fB-3lm4A:undetectable | 5z0fA-3lm4A:12.065z0fB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0G_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.20A | 5z0gA-3lm4A:undetectable5z0gB-3lm4A:undetectable | 5z0gA-3lm4A:12.065z0gB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0H_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.22A | 5z0hA-3lm4A:undetectable5z0hB-3lm4A:undetectable | 5z0hA-3lm4A:12.065z0hB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0I_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.21A | 5z0iA-3lm4A:undetectable5z0iB-3lm4A:undetectable | 5z0iA-3lm4A:12.065z0iB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0J_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.22A | 5z0jA-3lm4A:undetectable5z0jB-3lm4A:undetectable | 5z0jA-3lm4A:12.065z0jB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0K_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.22A | 5z0kA-3lm4A:undetectable5z0kB-3lm4A:undetectable | 5z0kA-3lm4A:12.065z0kB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0L_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.21A | 5z0lA-3lm4A:undetectable5z0lB-3lm4A:undetectable | 5z0lA-3lm4A:12.065z0lB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z0M_B_DAHB98_0 (MELCTYROSINASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 11 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.25A | 5z0mA-3lm4A:undetectable5z0mB-3lm4A:undetectable | 5z0mA-3lm4A:12.065z0mB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AYB_A_KKKA508_1 (CYP51, STEROL14ALPHA-DEMETHYLASE) |
3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) | 5 / 12 | PHE A 309ALA A 165THR A 178ILE A 251MET A 289 | HPX A 406 (-4.7A)NoneNoneHPX A 406 ( 3.9A)HPX A 406 ( 4.6A) | 1.15A | 6aybA-3lm4A:undetectable | 6aybA-3lm4A:22.77 |