SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HPR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		11 / 12 HIS A  15
HIS A  17
ASP A  19
PHE A  61
PHE A  65
MET A 155
ALA A 183
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 ZN  A 400 (-3.4A)
HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.34A 1a4lA-1uioA:
63.4		 1a4lA-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		6 / 12 HIS A  17
PHE A  65
MET A 155
ALA A 183
HIS A 214
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.6A)
 1.46A 1a4lA-1uioA:
63.4		 1a4lA-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 PHE A  61
PHE A  65
MET A 155
ALA A 183
HIS A  15
ASP A 295
ASP A 296
 HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 1.48A 1a4lA-1uioA:
63.4		 1a4lA-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		11 / 12 HIS A  17
ASP A  19
PHE A  61
LEU A  62
PHE A  65
MET A 155
ALA A 183
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-4.5A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.32A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		6 / 12 HIS A  17
ASP A  19
PHE A  61
PHE A  65
HIS A  15
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
ZN  A 400 (-3.4A)
HPR  A 353 (-2.6A)
 1.45A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
ASP A 296
LEU A  58
PHE A  61
ALA A 183
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.6A)
None
HPR  A 353 (-4.6A)
HPR  A 353 (-3.2A)
 1.45A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
PHE A  61
ALA A 183
ASP A 295
 HPR  A 353 ( 3.1A)
None
HPR  A 353 (-4.6A)
HPR  A 353 (-3.2A)
HPR  A 353 ( 2.5A)
 0.88A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
PHE A  61
ALA A 183
ASP A 296
 HPR  A 353 ( 3.1A)
None
HPR  A 353 (-4.6A)
HPR  A 353 (-3.2A)
HPR  A 353 (-2.6A)
 1.31A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		6 / 12 HIS A  17
MET A 155
ALA A 183
HIS A 214
GLU A 217
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 (-2.6A)
 1.33A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 HIS A  17
PHE A  61
LEU A  58
ALA A 183
HIS A 214
ASP A 295
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-4.6A)
None
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 1.33A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
PHE A  65
MET A 155
ALA A 183
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
HPR  A 353 (-2.6A)
 1.16A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 PHE A  61
LEU A  58
ALA A 183
HIS A  15
ASP A 296
 HPR  A 353 (-4.6A)
None
HPR  A 353 (-3.2A)
ZN  A 400 (-3.4A)
HPR  A 353 (-2.6A)
 1.44A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 PHE A  61
LEU A  62
HIS A 214
ASP A 295
ASP A 296
 HPR  A 353 (-4.6A)
HPR  A 353 (-4.5A)
ZN  A 400 ( 3.3A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 1.30A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 PHE A  61
LEU A  62
PHE A  65
MET A 155
ALA A 183
HIS A  15
ASP A 296
 HPR  A 353 (-4.6A)
HPR  A 353 (-4.5A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 (-3.4A)
HPR  A 353 (-2.6A)
 1.43A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 5 HIS A  15
LEU A  58
SER A 103
LEU A 106
GLY A 184
 ZN  A 400 (-3.4A)
None
None
None
HPR  A 353 (-3.8A)
 0.18A 1a4lB-1uioA:
63.3		 1a4lB-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		11 / 12 HIS A  15
HIS A  17
ASP A  19
PHE A  61
PHE A  65
MET A 155
ALA A 183
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 ZN  A 400 (-3.4A)
HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.31A 1a4lC-1uioA:
63.0		 1a4lC-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
MET A 155
ALA A 183
HIS A 214
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.6A)
 1.29A 1a4lC-1uioA:
63.0		 1a4lC-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
PHE A  65
MET A 155
ALA A 183
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
HPR  A 353 (-2.6A)
 1.14A 1a4lC-1uioA:
63.0		 1a4lC-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 PHE A  61
PHE A  65
MET A 155
ALA A 183
HIS A  15
ASP A 295
ASP A 296
 HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 1.47A 1a4lC-1uioA:
63.0		 1a4lC-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 5 LEU A  58
LEU A  62
SER A 103
LEU A 106
GLY A 184
 None
HPR  A 353 (-4.5A)
None
None
HPR  A 353 (-3.8A)
 0.24A 1a4lC-1uioA:
63.0		 1a4lC-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		6 / 12 HIS A  17
ASP A  19
PHE A  61
PHE A  65
HIS A  15
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
ZN  A 400 (-3.4A)
HPR  A 353 (-2.6A)
 1.47A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		11 / 12 HIS A  17
ASP A  19
PHE A  61
PHE A  65
MET A 155
ALA A 183
GLY A 184
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
HPR  A 353 (-3.8A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.33A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
ASP A 296
PHE A  61
ALA A 183
GLY A 184
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.6A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.2A)
HPR  A 353 (-3.8A)
 1.45A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 HIS A  17
MET A 155
ALA A 183
GLY A 184
HIS A 214
GLU A 217
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
HPR  A 353 (-3.8A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 (-2.6A)
 1.24A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
PHE A  61
ALA A 183
GLY A 184
ASP A 295
 HPR  A 353 ( 3.1A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.2A)
HPR  A 353 (-3.8A)
HPR  A 353 ( 2.5A)
 0.99A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 HIS A  17
PHE A  65
MET A 155
ALA A 183
GLY A 184
HIS A 214
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
HPR  A 353 (-3.8A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.6A)
 1.40A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
PHE A 300
PHE A  61
HIS A  15
ASP A 296
 HPR  A 353 ( 3.1A)
None
HPR  A 353 (-4.6A)
ZN  A 400 (-3.4A)
HPR  A 353 (-2.6A)
 1.28A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		8 / 12 PHE A  61
PHE A  65
MET A 155
ALA A 183
GLY A 184
HIS A  15
ASP A 295
ASP A 296
 HPR  A 353 (-4.6A)
HPR  A 353 (-3.9A)
HPR  A 353 (-4.1A)
HPR  A 353 (-3.2A)
HPR  A 353 (-3.8A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 1.42A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 4 HIS A  15
LEU A  58
LEU A  62
LEU A 106
 ZN  A 400 (-3.4A)
None
HPR  A 353 (-4.5A)
None
 0.26A 1a4lD-1uioA:
63.3		 1a4lD-1uioA:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 11 GLU A 260
HIS A 214
GLY A 237
HIS A  17
PRO A 297
 None
ZN  A 400 ( 3.3A)
None
HPR  A 353 ( 3.1A)
None
 1.47A 1mjqA-1uioA:
undetectable
1mjqB-1uioA:
undetectable		 1mjqA-1uioA:
15.03
1mjqB-1uioA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 4 HIS A  15
GLU A 260
HIS A 214
HIS A  17
 ZN  A 400 (-3.4A)
None
ZN  A 400 ( 3.3A)
HPR  A 353 ( 3.1A)
 1.30A 2ozrE-1uioA:
undetectable		 2ozrE-1uioA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
ASP A  19
HIS A  15
SER A 265
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 4.8A)
HPR  A 353 (-2.6A)
 1.39A 2pgfA-1uioA:
41.7		 2pgfA-1uioA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		9 / 12 HIS A  17
ASP A  19
PHE A  61
GLY A 184
HIS A 214
GLU A 217
SER A 265
ASP A 295
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.8A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 4.8A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.48A 2pgfA-1uioA:
41.7		 2pgfA-1uioA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		9 / 12 HIS A  15
HIS A  17
ASP A  19
PHE A  61
GLY A 184
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 ZN  A 400 (-3.4A)
HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
HPR  A 353 (-4.6A)
HPR  A 353 (-3.8A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.53A 2pgrA-1uioA:
41.7		 2pgrA-1uioA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		6 / 12 HIS A 214
HIS A  17
ASP A  19
HIS A  15
GLU A 260
ASP A 181
 ZN  A 400 ( 3.3A)
HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
ZN  A 400 (-3.4A)
None
None
 1.38A 2pgrA-1uioA:
41.7		 2pgrA-1uioA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 8 HIS A 214
ASP A 181
ILE A 151
HIS A  17
 ZN  A 400 ( 3.3A)
None
None
HPR  A 353 ( 3.1A)
 0.91A 2xadA-1uioA:
undetectable		 2xadA-1uioA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 8 HIS A 214
ASP A 181
ILE A 151
HIS A  17
 ZN  A 400 ( 3.3A)
None
None
HPR  A 353 ( 3.1A)
 0.93A 2xadB-1uioA:
undetectable		 2xadB-1uioA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 8 HIS A 214
ASP A 181
ILE A 151
HIS A  17
 ZN  A 400 ( 3.3A)
None
None
HPR  A 353 ( 3.1A)
 0.95A 2xadC-1uioA:
undetectable		 2xadC-1uioA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 8 HIS A 214
ASP A 181
ILE A 151
HIS A  17
 ZN  A 400 ( 3.3A)
None
None
HPR  A 353 ( 3.1A)
 0.90A 2xadD-1uioA:
undetectable		 2xadD-1uioA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 5 HIS A  15
HIS A 214
ASP A 295
ASP A 296
 ZN  A 400 (-3.4A)
ZN  A 400 ( 3.3A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 1.17A 3c0zA-1uioA:
undetectable		 3c0zA-1uioA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		3 / 3 HIS A 214
HIS A  15
HIS A  17
 ZN  A 400 ( 3.3A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 3.1A)
 0.60A 3qpkA-1uioA:
undetectable		 3qpkA-1uioA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 THR A 233
GLU A 260
HIS A  15
ASP A 295
ASP A 181
 None
None
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
None
 1.45A 3ximB-1uioA:
4.0		 3ximB-1uioA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 THR A 233
GLU A 260
HIS A  15
ASP A 295
ASP A 181
 None
None
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
None
 1.49A 3ximC-1uioA:
3.8		 3ximC-1uioA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 LEU A  58
LEU A  62
HIS A 214
GLU A 217
GLU A 186
SER A 265
ASP A 295
 None
HPR  A 353 (-4.5A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
None
HPR  A 353 ( 4.8A)
HPR  A 353 ( 2.5A)
 0.88A 4aqlA-1uioA:
21.8		 4aqlA-1uioA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
HIS A 214
GLU A 217
ASP A 295
 HPR  A 353 ( 3.1A)
None
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
 0.37A 4r88B-1uioA:
22.9		 4r88B-1uioA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
HIS A 214
GLU A 217
ASP A 295
 HPR  A 353 ( 3.1A)
None
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
 0.40A 4r88C-1uioA:
22.7		 4r88C-1uioA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
HIS A 214
GLU A 217
ASP A 295
 HPR  A 353 ( 3.1A)
None
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
 0.36A 4r88D-1uioA:
22.7		 4r88D-1uioA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
HIS A 214
GLU A 217
ASP A 295
 HPR  A 353 ( 3.1A)
None
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
 0.39A 4r88E-1uioA:
22.9		 4r88E-1uioA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A  17
LEU A  58
HIS A 214
GLU A 217
ASP A 295
 HPR  A 353 ( 3.1A)
None
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
 0.39A 4r88F-1uioA:
20.7		 4r88F-1uioA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 8 ASP A 296
ASP A 295
GLU A 260
ASP A 181
 HPR  A 353 (-2.6A)
HPR  A 353 ( 2.5A)
None
None
 0.95A 4xjeA-1uioA:
undetectable		 4xjeA-1uioA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		4 / 8 ASP A 296
ASP A 295
GLU A 260
ASP A 181
 HPR  A 353 (-2.6A)
HPR  A 353 ( 2.5A)
None
None
 0.84A 5cfsA-1uioA:
undetectable		 5cfsA-1uioA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		3 / 3 HIS A 214
HIS A  15
HIS A  17
 ZN  A 400 ( 3.3A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 3.1A)
 0.55A 5migA-1uioA:
undetectable		 5migA-1uioA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 THR A 233
GLU A 260
HIS A  15
ASP A 295
ASP A 181
 None
None
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
None
 1.50A 5ximA-1uioA:
3.8		 5ximA-1uioA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 THR A 233
GLU A 260
HIS A  15
ASP A 295
ASP A 181
 None
None
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
None
 1.48A 5ximD-1uioA:
4.8		 5ximD-1uioA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		9 / 12 HIS A  17
ASP A  19
LEU A  58
LEU A  62
ALA A 183
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
None
HPR  A 353 (-4.5A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.54A 6n91A-1uioA:
45.3		 6n91A-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		7 / 12 HIS A  17
LEU A  58
LEU A  62
ALA A 183
HIS A 214
GLU A 217
ASP A 296
 HPR  A 353 ( 3.1A)
None
HPR  A 353 (-4.5A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 (-2.6A)
 1.13A 6n91A-1uioA:
45.3		 6n91A-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A 214
LEU A  62
LEU A  58
SER A 265
HIS A  17
 ZN  A 400 ( 3.3A)
HPR  A 353 (-4.5A)
None
HPR  A 353 ( 4.8A)
HPR  A 353 ( 3.1A)
 1.23A 6n91A-1uioA:
45.3		 6n91A-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 LEU A  58
ALA A 183
HIS A 214
HIS A  15
ASP A 295
 None
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
 1.32A 6n91A-1uioA:
45.3		 6n91A-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		9 / 12 HIS A  17
ASP A  19
LEU A  58
LEU A  62
ALA A 183
HIS A 214
GLU A 217
ASP A 295
ASP A 296
 HPR  A 353 ( 3.1A)
HPR  A 353 (-2.7A)
None
HPR  A 353 (-4.5A)
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
HPR  A 353 (-2.7A)
HPR  A 353 ( 2.5A)
HPR  A 353 (-2.6A)
 0.58A 6n91B-1uioA:
45.3		 6n91B-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		6 / 12 HIS A  17
LEU A  58
LEU A  62
ALA A 183
GLU A 217
ASP A 296
 HPR  A 353 ( 3.1A)
None
HPR  A 353 (-4.5A)
HPR  A 353 (-3.2A)
HPR  A 353 (-2.7A)
HPR  A 353 (-2.6A)
 1.12A 6n91B-1uioA:
45.3		 6n91B-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 HIS A 214
LEU A  62
LEU A  58
SER A 265
HIS A  17
 ZN  A 400 ( 3.3A)
HPR  A 353 (-4.5A)
None
HPR  A 353 ( 4.8A)
HPR  A 353 ( 3.1A)
 1.19A 6n91B-1uioA:
45.3		 6n91B-1uioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 1uio ADENOSINE DEAMINASE
(Mus
musculus) 		5 / 12 LEU A  58
ALA A 183
HIS A 214
HIS A  15
ASP A 295
 None
HPR  A 353 (-3.2A)
ZN  A 400 ( 3.3A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 2.5A)
 1.30A 6n91B-1uioA:
45.3		 6n91B-1uioA:
11.46