SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HPO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 12 ASP A 212
VAL A 213
SER A 154
GLY A  19
PHE A  32
 MG  A1258 (-2.6A)
None
HPO  A1261 (-2.3A)
MG  A1258 ( 4.4A)
HPO  A1261 (-4.6A)
 1.24A 4pevB-1ynsA:
4.2		 4pevB-1ynsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1yns E-1 ENZYME
(Homo
sapiens) 		4 / 8 GLU A  36
VAL A  27
LEU A  31
GLY A 115
 None
HPO  A1261 ( 4.8A)
None
None
 0.89A 4r3aA-1ynsA:
undetectable		 4r3aA-1ynsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 11 GLY A 155
GLY A 115
GLN A 114
THR A 107
THR A 108
 HPO  A1261 ( 3.8A)
None
None
None
None
 1.24A 5x1bG-1ynsA:
0.0
5x1bN-1ynsA:
0.0
5x1bO-1ynsA:
0.0		 5x1bG-1ynsA:
13.79
5x1bN-1ynsA:
17.94
5x1bO-1ynsA:
20.92