SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HPN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_5 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	1nww	LIMONENE-1,2-EPOXIDE HYDROLASE (Rhodococcus erythropolis)	3 / 3	THR A 70 LEU A 74 VAL A 77	None HPN A 900 ( 4.8A) None	0.47A	1mz9E-1nwwA: undetectable	1mz9E-1nwwA: 16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FUK_A_SNPA1236_1 (MROUPO)	1nww	LIMONENE-1,2-EPOXIDE HYDROLASE (Rhodococcus erythropolis)	4 / 7	ILE A 5 ILE A 80 ILE A 116 LEU A 35	None HPN A 900 ( 4.4A) None None	0.81A	5fukA-1nwwA: undetectable 5fukB-1nwwA: undetectable	5fukA-1nwwA: 21.16 5fukB-1nwwA: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEF_A_NBVA1005_1 (NEUTRAL ALPHA-GLUCOSIDASE AB)	1nww	LIMONENE-1,2-EPOXIDE HYDROLASE (Rhodococcus erythropolis)	5 / 12	TRP A 130 ASP A 132 ILE A 116 ASP A 101 PHE A 75	None HPN A 900 (-4.3A) None HPN A 900 (-3.4A) None	1.28A	5iefA-1nwwA: undetectable	5iefA-1nwwA: 11.08