SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HPA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 10 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1c9sN-2w55B:
undetectable
1c9sO-2w55B:
undetectable		 1c9sN-2w55B:
7.21
1c9sO-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1c9sP-2w55B:
undetectable
1c9sQ-2w55B:
undetectable		 1c9sP-2w55B:
7.21
1c9sQ-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 10 GLY B 345
GLY B 456
HIS B 314
ALA B 529
ILE B 457
 None
None
None
HPA  B1780 ( 3.2A)
None
 0.90A 1c9sL-2w55B:
undetectable
1c9sV-2w55B:
undetectable		 1c9sL-2w55B:
7.21
1c9sV-2w55B:
7.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 LEU B 303
ARG B 310
PHE B 344
LEU B 461
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
None
 0.87A 1fiqC-2w55B:
53.6		 1fiqC-2w55B:
40.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 8 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.35A 1fiqC-2w55B:
53.6		 1fiqC-2w55B:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 1fo4A-2w55B:
43.4		 1fo4A-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 7 ARG B 310
PHE B 344
THR B 460
ALA B 528
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
 0.33A 1fo4B-2w55B:
35.1		 1fo4B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1gtfQ-2w55B:
undetectable
1gtfR-2w55B:
undetectable		 1gtfQ-2w55B:
7.21
1gtfR-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1gtfS-2w55B:
undetectable
1gtfT-2w55B:
undetectable		 1gtfS-2w55B:
7.21
1gtfT-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.92A 1gtnT-2w55B:
undetectable
1gtnU-2w55B:
undetectable		 1gtnT-2w55B:
7.21
1gtnU-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 GLY B 345
GLY B 456
HIS B 314
ALA B 529
ILE B 457
 None
None
None
HPA  B1780 ( 3.2A)
None
 0.92A 1gtnL-2w55B:
undetectable
1gtnV-2w55B:
undetectable		 1gtnL-2w55B:
7.21
1gtnV-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 12 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.34A 1n5xA-2w55B:
55.7		 1n5xA-2w55B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 12 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.34A 1n5xB-2w55B:
55.8		 1n5xB-2w55B:
26.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		9 / 10 GLY A 118
PHE A 200
GLU A 201
VAL A 217
GLY A 218
MET A 219
THR A 242
ASN A 243
HIS A 257
 HPA  A 300 (-3.6A)
HPA  A 300 (-4.7A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 (-4.5A)
HPA  A 300 ( 2.9A)
None
 0.68A 1pwyE-1vfnA:
41.2		 1pwyE-1vfnA:
88.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 GLY A 218
PHE A 200
GLU A 201
GLY A 197
VAL A 217
HIS A 257
 HPA  A 300 (-3.6A)
HPA  A 300 (-4.7A)
HPA  A 300 ( 2.8A)
None
HPA  A 300 (-4.5A)
None
 1.16A 1pwyE-1vfnA:
41.2		 1pwyE-1vfnA:
88.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 102
GLU A 181
VAL A 197
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.52A 1pwyE-3ozbA:
23.4		 1pwyE-3ozbA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		6 / 10 GLY A 110
GLU A 185
VAL A 201
GLY A 202
THR A 226
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.2A)
HPA  A 301 (-3.0A)
 0.62A 1pwyE-4uc0A:
32.6		 1pwyE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		7 / 10 GLY A 110
PHE A 184
GLU A 185
GLY A 202
MET A 203
THR A 226
ASN A 227
 HPA  A 301 (-3.5A)
None
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-4.2A)
HPA  A 301 (-3.0A)
 0.60A 1pwyE-4uc0A:
32.6		 1pwyE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 GLY A 202
PHE A 184
GLU A 185
GLY A 181
VAL A 201
 HPA  A 301 (-3.6A)
None
HPA  A 301 (-2.9A)
None
HPA  A 301 (-4.9A)
 1.25A 1pwyE-4uc0A:
32.6		 1pwyE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 10 GLY A 131
PHE A 213
GLU A 214
VAL A 230
GLY A 231
MET A 232
THR A 255
ASN A 256
HIS A 281
 HPA  A 401 (-3.5A)
HPA  A 401 (-4.9A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-4.0A)
HPA  A 401 (-2.9A)
None
 0.73A 1pwyE-5ifkA:
37.1		 1pwyE-5ifkA:
44.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1utdO-2w55B:
undetectable
1utdP-2w55B:
undetectable		 1utdO-2w55B:
7.21
1utdP-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.92A 1utdP-2w55B:
undetectable
1utdQ-2w55B:
undetectable		 1utdP-2w55B:
7.21
1utdQ-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.90A 1utdS-2w55B:
undetectable
1utdT-2w55B:
undetectable		 1utdS-2w55B:
7.21
1utdT-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 10 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1utdU-2w55B:
undetectable
1utdV-2w55B:
undetectable		 1utdU-2w55B:
7.21
1utdV-2w55B:
7.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		9 / 10 GLY A 118
PHE A 200
GLU A 201
VAL A 217
GLY A 218
MET A 219
THR A 242
ASN A 243
HIS A 257
 HPA  A 300 (-3.6A)
HPA  A 300 (-4.7A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 (-4.5A)
HPA  A 300 ( 2.9A)
None
 0.57A 1v3qE-1vfnA:
42.9		 1v3qE-1vfnA:
88.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 GLY A 218
PHE A 200
GLU A 201
GLY A 197
HIS A 257
 HPA  A 300 (-3.6A)
HPA  A 300 (-4.7A)
HPA  A 300 ( 2.8A)
None
None
 1.18A 1v3qE-1vfnA:
42.9		 1v3qE-1vfnA:
88.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 PHE A 200
GLU A 201
GLY A 197
VAL A 217
HIS A 257
 HPA  A 300 (-4.7A)
HPA  A 300 ( 2.8A)
None
HPA  A 300 (-4.5A)
None
 1.12A 1v3qE-1vfnA:
42.9		 1v3qE-1vfnA:
88.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 102
GLU A 181
VAL A 197
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.32A 1v3qE-3ozbA:
24.2		 1v3qE-3ozbA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 10 GLY A 110
PHE A 184
GLU A 185
VAL A 201
GLY A 202
MET A 203
THR A 226
ASN A 227
 HPA  A 301 (-3.5A)
None
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-4.2A)
HPA  A 301 (-3.0A)
 0.54A 1v3qE-4uc0A:
32.9		 1v3qE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 10 GLY A 131
PHE A 213
GLU A 214
VAL A 230
GLY A 231
MET A 232
THR A 255
ASN A 256
HIS A 281
 HPA  A 401 (-3.5A)
HPA  A 401 (-4.9A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-4.0A)
HPA  A 401 (-2.9A)
None
 0.54A 1v3qE-5ifkA:
38.3		 1v3qE-5ifkA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 10 GLY A 231
PHE A 213
GLU A 214
GLY A 210
HIS A 281
 HPA  A 401 (-3.5A)
HPA  A 401 (-4.9A)
HPA  A 401 (-2.7A)
None
None
 1.27A 1v3qE-5ifkA:
38.3		 1v3qE-5ifkA:
44.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		8 / 10 LEU B 303
ARG B 310
PHE B 344
PHE B 459
THR B 460
ALA B 528
ALA B 529
GLU B 730
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-4.8A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
XAX  B1778 (-3.3A)
 0.51A 1wygA-2w55B:
48.4		 1wygA-2w55B:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 10 LEU B 303
PHE B 344
PHE B 459
ALA B 528
GLU B 730
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-4.8A)
XAX  B1778 ( 3.2A)
XAX  B1778 (-3.3A)
 1.48A 1wygA-2w55B:
48.4		 1wygA-2w55B:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.21A 1ymxA-1jftA:
undetectable		 1ymxA-1jftA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.21A 1ymxB-1jftA:
undetectable		 1ymxB-1jftA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 197
GLY A 198
ALA A 173
LEU A 189
ARG A 188
 HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
None
None
None
 1.19A 2bxgA-3ozbA:
undetectable		 2bxgA-3ozbA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 6 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.43A 2e1qA-2w55B:
43.5		 2e1qA-2w55B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_B_SALB3006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 4 ARG B 310
PHE B 344
THR B 460
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
HPA  B1780 ( 3.2A)
 0.36A 2e1qB-2w55B:
47.4		 2e1qB-2w55B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 6 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 2e1qC-2w55B:
56.8		 2e1qC-2w55B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 5 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.38A 2e1qD-2w55B:
52.5		 2e1qD-2w55B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 LEU B 464
LEU B 461
ALA B 529
ALA B 340
 None
None
HPA  B1780 ( 3.2A)
XAX  B1778 ( 4.1A)
 0.80A 2vcvP-2w55B:
undetectable		 2vcvP-2w55B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 GLN B 348
PHE B 344
GLY B 345
GLY B 230
 None
HPA  B1780 (-3.4A)
None
None
 0.91A 2y6rB-2w55B:
undetectable		 2y6rB-2w55B:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 2zj0A-2w55B:
undetectable		 2zj0A-2w55B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 8 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.43A 3ax7A-2w55B:
49.9		 3ax7A-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.41A 3ax7B-2w55B:
51.4		 3ax7B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 8 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
HPA  B1780 ( 3.2A)
 0.40A 3ax9A-2w55B:
52.8		 3ax9A-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 8 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.29A 3ax9B-2w55B:
56.5		 3ax9B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 3ce6A-2w55B:
undetectable		 3ce6A-2w55B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 3ce6C-2w55B:
undetectable		 3ce6C-2w55B:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		5 / 6 GLY A 118
GLU A 201
GLY A 218
MET A 219
ASN A 243
 HPA  A 300 (-3.6A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 ( 2.9A)
 0.65A 3e9rA-1vfnA:
39.6		 3e9rA-1vfnA:
48.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		5 / 6 GLY A 102
GLU A 181
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.62A 3e9rA-3ozbA:
24.8		 3e9rA-3ozbA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 6 GLY A 110
GLU A 185
GLY A 202
MET A 203
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3e9rA-4uc0A:
33.0		 3e9rA-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 6 GLY A 131
GLU A 214
GLY A 231
MET A 232
ASN A 256
 HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
 0.49A 3e9rA-5ifkA:
39.6		 3e9rA-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		5 / 6 GLY A 118
GLU A 201
GLY A 218
MET A 219
ASN A 243
 HPA  A 300 (-3.6A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 ( 2.9A)
 0.66A 3e9rC-1vfnA:
39.7		 3e9rC-1vfnA:
48.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		5 / 6 GLY A 102
GLU A 181
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.64A 3e9rC-3ozbA:
24.8		 3e9rC-3ozbA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 6 GLY A 110
GLU A 185
GLY A 202
MET A 203
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.63A 3e9rC-4uc0A:
32.8		 3e9rC-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 6 GLY A 131
GLU A 214
GLY A 231
MET A 232
ASN A 256
 HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
 0.53A 3e9rC-5ifkA:
39.3		 3e9rC-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		10 / 12 SER A  33
TYR A  88
ALA A 116
GLY A 118
GLU A 201
VAL A 217
GLY A 218
MET A 219
ASN A 243
HIS A 257
 None
None
HPA  A 300 ( 4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 ( 2.9A)
None
 0.51A 3f8wA-1vfnA:
41.0		 3f8wA-1vfnA:
48.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 100
GLU A 181
GLY A 198
MET A 199
ASN A 223
VAL A 222
 HPA  A 260 (-4.6A)
HPA  A 260 (-2.9A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
None
 1.36A 3f8wA-3ozbA:
25.0		 3f8wA-3ozbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		7 / 12 ALA A 100
GLY A 102
GLU A 181
VAL A 197
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-4.6A)
HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.44A 3f8wA-3ozbA:
25.0		 3f8wA-3ozbA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 SER A  25
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3f8wA-4uc0A:
33.4		 3f8wA-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 TYR A  80
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.43A 3f8wA-4uc0A:
33.4		 3f8wA-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 12 SER A  42
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 1.00A 3f8wA-5ifkA:
38.8		 3f8wA-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		10 / 12 TYR A 100
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
HIS A 281
VAL A 284
 None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
None
HPA  A 401 ( 4.7A)
 0.41A 3f8wA-5ifkA:
38.8		 3f8wA-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		10 / 12 SER A  33
HIS A  86
TYR A  88
GLY A 118
GLU A 201
VAL A 217
GLY A 218
MET A 219
ASN A 243
HIS A 257
 None
None
None
HPA  A 300 (-3.6A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 ( 2.9A)
None
 0.46A 3f8wB-1vfnA:
40.8		 3f8wB-1vfnA:
48.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 181
GLY A 198
MET A 199
ASN A 223
VAL A 222
 HPA  A 260 (-2.9A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
None
 1.20A 3f8wB-3ozbA:
25.0		 3f8wB-3ozbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 102
GLU A 181
VAL A 197
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.40A 3f8wB-3ozbA:
25.0		 3f8wB-3ozbA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 HIS A  78
TYR A  80
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.43A 3f8wB-4uc0A:
33.3		 3f8wB-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 SER A  25
HIS A  78
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.62A 3f8wB-4uc0A:
33.3		 3f8wB-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		10 / 12 HIS A  98
TYR A 100
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
HIS A 281
VAL A 284
 None
None
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
None
HPA  A 401 ( 4.7A)
 0.41A 3f8wB-5ifkA:
38.7		 3f8wB-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		8 / 12 SER A  42
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 0.97A 3f8wB-5ifkA:
38.7		 3f8wB-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Bos
taurus) 		10 / 12 SER A  33
HIS A  86
TYR A  88
ALA A 116
GLY A 118
GLU A 201
VAL A 217
GLY A 218
MET A 219
ASN A 243
 None
None
None
HPA  A 300 ( 4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-4.5A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 ( 2.9A)
 0.45A 3f8wC-1vfnA:
41.0		 3f8wC-1vfnA:
48.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 100
GLU A 181
GLY A 198
MET A 199
ASN A 223
VAL A 222
 HPA  A 260 (-4.6A)
HPA  A 260 (-2.9A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
None
 1.37A 3f8wC-3ozbA:
25.1		 3f8wC-3ozbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		7 / 12 ALA A 100
GLY A 102
GLU A 181
VAL A 197
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-4.6A)
HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.44A 3f8wC-3ozbA:
25.1		 3f8wC-3ozbA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		9 / 12 HIS A  78
TYR A  80
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.40A 3f8wC-4uc0A:
33.5		 3f8wC-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		9 / 12 SER A  25
HIS A  78
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3f8wC-4uc0A:
33.5		 3f8wC-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		10 / 12 HIS A  98
TYR A 100
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 0.35A 3f8wC-5ifkA:
38.9		 3f8wC-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 12 SER A  42
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 1.00A 3f8wC-5ifkA:
38.9		 3f8wC-5ifkA:
42.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 ARG B 310
THR B 460
LEU B 461
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.71A 3hrdA-2w55B:
26.1
3hrdB-2w55B:
20.7		 3hrdA-2w55B:
19.60
3hrdB-2w55B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		4 / 7 LEU A 298
LEU A 142
SER A  42
THR A 255
 None
None
None
HPA  A 401 (-4.0A)
 0.92A 3lm8A-5ifkA:
undetectable
3lm8C-5ifkA:
undetectable		 3lm8A-5ifkA:
19.56
3lm8C-5ifkA:
19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 6 ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.44A 3ns1C-2w55B:
55.5		 3ns1C-2w55B:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 8 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.42A 3ns1L-2w55B:
48.9		 3ns1L-2w55B:
40.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.21A 3q07A-1jftA:
undetectable		 3q07A-1jftA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.20A 3q07B-1jftA:
undetectable		 3q07B-1jftA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.40A 3unaA-2w55B:
58.4		 3unaA-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.39A 3unaB-2w55B:
51.7		 3unaB-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.42A 3uncA-2w55B:
55.9		 3uncA-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 3uncB-2w55B:
47.0		 3uncB-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 7 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.39A 3uniA-2w55B:
51.7		 3uniA-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 8 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 3uniB-2w55B:
56.6		 3uniB-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 VAL A 183
GLY A 186
PHE A 244
GLY A 273
ASP A 275
 None
None
None
None
HPA  A 599 (-2.8A)
 1.39A 4pevB-1jftA:
19.0		 4pevB-1jftA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 11 PHE A 244
ASP A 248
TYR A  73
GLY A 166
GLY A 273
 None
None
HPA  A 599 (-3.2A)
None
None
 1.01A 4xnxA-1jftA:
0.0		 4xnxA-1jftA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.01A 4z4cA-1jftA:
7.5		 4z4cA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.02A 4z4fA-1jftA:
7.4		 4z4fA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.02A 4z4gA-1jftA:
7.5		 4z4gA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 0.98A 4z4iA-1jftA:
7.1		 4z4iA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 MET A 201
PHE A 200
GLY A 195
ARG A 196
GLY A 166
 None
None
None
HPA  A 599 (-3.1A)
None
 1.41A 5l8rA-1jftA:
undetectable		 5l8rA-1jftA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 PRO B 306
THR B 460
TRP B 674
ALA B 528
 HPA  B1780 (-4.8A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
 1.01A 5x2tI-2w55B:
undetectable
5x2tJ-2w55B:
undetectable
5x2tK-2w55B:
undetectable
5x2tL-2w55B:
undetectable		 5x2tI-2w55B:
11.04
5x2tJ-2w55B:
10.86
5x2tK-2w55B:
11.04
5x2tL-2w55B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 PHE B 272
ARG B 330
TRP B 146
HIS B 404
THR B 460
 None
None
None
None
HPA  B1780 (-3.6A)
 1.36A 5xioA-2w55B:
undetectable		 5xioA-2w55B:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 PHE B 272
ARG B 330
TRP B 146
HIS B 404
THR B 460
 None
None
None
None
HPA  B1780 (-3.6A)
 1.35A 5xioB-2w55B:
undetectable		 5xioB-2w55B:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 PHE B 272
ARG B 330
TRP B 146
HIS B 404
THR B 460
 None
None
None
None
HPA  B1780 (-3.6A)
 1.39A 5xipB-2w55B:
undetectable		 5xipB-2w55B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 PHE B 272
ARG B 330
TRP B 146
HIS B 404
THR B 460
 None
None
None
None
HPA  B1780 (-3.6A)
 1.43A 5xiqB-2w55B:
undetectable		 5xiqB-2w55B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 PHE B 272
ARG B 330
TRP B 146
HIS B 404
THR B 460
 None
None
None
None
HPA  B1780 (-3.6A)
 1.41A 5xiqC-2w55B:
undetectable		 5xiqC-2w55B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 198
ILE A 196
VAL A 222
ALA A 173
PRO A 116
 HPA  A 260 (-3.3A)
None
None
None
None
 1.08A 6bq4B-3ozbA:
undetectable		 6bq4B-3ozbA:
16.81