SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HP7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3q2i DEHYDROGENASE
(Chromobacterium
violaceum) 		3 / 3 SER A  83
ASP A 182
GLN A 189
 NAI  A 500 (-2.7A)
None
HP7  A 550 (-4.8A)
 0.54A 4oltA-3q2iA:
undetectable
4oltB-3q2iA:
undetectable		 4oltA-3q2iA:
22.56
4oltB-3q2iA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3q2k OXIDOREDUCTASE
(Bordetella
pertussis) 		3 / 3 SER A  82
ASP A 181
GLN A 188
 NAI  A 500 (-2.7A)
None
HP7  A 550 (-3.9A)
 0.65A 4oltA-3q2kA:
undetectable
4oltB-3q2kA:
undetectable		 4oltA-3q2kA:
21.74
4oltB-3q2kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3q2i DEHYDROGENASE
(Chromobacterium
violaceum) 		3 / 3 GLN A 189
SER A  83
ASP A 182
 HP7  A 550 (-4.8A)
NAI  A 500 (-2.7A)
None
 0.58A 4qwpA-3q2iA:
undetectable
4qwpB-3q2iA:
undetectable		 4qwpA-3q2iA:
21.75
4qwpB-3q2iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3q2k OXIDOREDUCTASE
(Bordetella
pertussis) 		3 / 3 GLN A 188
SER A  82
ASP A 181
 HP7  A 550 (-3.9A)
NAI  A 500 (-2.7A)
None
 0.64A 4qwpA-3q2kA:
undetectable
4qwpB-3q2kA:
undetectable		 4qwpA-3q2kA:
21.74
4qwpB-3q2kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3q2k OXIDOREDUCTASE
(Bordetella
pertussis) 		4 / 5 GLN A 139
GLU A 319
ASP A 306
ASN A 132
 None
None
None
HP7  A 550 ( 3.9A)
 1.36A 6iftA-3q2kA:
2.6		 6iftA-3q2kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 7 ARG A  16
ALA A  20
ILE A  13
ALA A  14
 HP7  A 312 ( 3.6A)
None
NAD  A 311 (-4.0A)
None
 0.99A 6ma7A-3oa0A:
undetectable		 6ma7A-3oa0A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3q2k OXIDOREDUCTASE
(Bordetella
pertussis) 		4 / 7 GLY A 265
HIS A 191
ASN A 132
GLY A 298
 None
HP7  A 550 ( 3.7A)
HP7  A 550 ( 3.9A)
HP7  A 550 ( 4.4A)
 0.95A 6n7fA-3q2kA:
undetectable		 6n7fA-3q2kA:
13.70