SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HNA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HNA  A 351 (-3.8A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.6A)
 1.48A 1xlxA-1m2pA:
undetectable		 1xlxA-1m2pA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HNA  A 351 (-3.8A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.6A)
 1.44A 1xomA-1m2pA:
undetectable		 1xomA-1m2pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HNA  A 351 (-3.8A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.6A)
 1.43A 1xomB-1m2pA:
undetectable		 1xomB-1m2pA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		6 / 12 VAL A  53
LYS A  68
VAL A  95
PHE A 113
ASN A 161
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
None
HNA  A 351 (-3.6A)
None
HNA  A 351 (-3.3A)
 0.53A 2eufB-1m2pA:
30.6		 2eufB-1m2pA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		7 / 12 GLY A  46
VAL A  53
VAL A 116
ASP A 156
LYS A 158
ASN A 161
MET A 163
 HNA  A 351 (-2.8A)
HNA  A 351 (-4.5A)
HNA  A 351 (-3.8A)
None
None
None
HNA  A 351 ( 3.8A)
 0.88A 2fumA-1m2pA:
24.5		 2fumA-1m2pA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		7 / 12 VAL A  53
VAL A 116
ASP A 156
LYS A 158
ASN A 161
MET A 163
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-3.8A)
None
None
None
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.3A)
 0.93A 2fumA-1m2pA:
24.5		 2fumA-1m2pA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HNA  A 351 (-3.8A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.6A)
 1.42A 3g4lB-1m2pA:
undetectable		 3g4lB-1m2pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		4 / 8 VAL A  45
LYS A  68
GLU A  81
LEU A 111
 HNA  A 351 (-4.3A)
HNA  A 351 (-2.6A)
None
None
 0.29A 3lfaA-1m2pA:
24.8		 3lfaA-1m2pA:
27.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		6 / 8 VAL A  53
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.46A 3warA-1m2pA:
50.0		 3warA-1m2pA:
76.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		7 / 12 VAL A  53
ASP A 120
ASP A 156
LYS A 158
ASN A 161
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
None
None
None
None
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.71A 4i41A-1m2pA:
25.3		 4i41A-1m2pA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		6 / 10 VAL A  53
GLU A  81
LEU A  88
ILE A  94
VAL A  95
TYR A 115
 HNA  A 351 (-4.5A)
None
None
None
None
None
 0.84A 4u0iA-1m2pA:
21.8		 4u0iA-1m2pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		4 / 7 GLY A  46
GLY A  48
LYS A  68
LEU A  70
 HNA  A 351 (-2.8A)
HNA  A 351 ( 4.6A)
HNA  A 351 (-2.6A)
None
 0.72A 5izfA-1m2pA:
24.5		 5izfA-1m2pA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		4 / 7 GLY A  46
GLY A  48
VAL A  53
LYS A  68
 HNA  A 351 (-2.8A)
HNA  A 351 ( 4.6A)
HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
 0.44A 5izjA-1m2pA:
24.6		 5izjA-1m2pA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		4 / 7 GLY A  46
GLY A  48
VAL A  53
LYS A  68
 HNA  A 351 (-2.8A)
HNA  A 351 ( 4.6A)
HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
 0.43A 5j5xA-1m2pA:
24.5		 5j5xA-1m2pA:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		6 / 8 VAL A  53
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.72A 5y9mA-1m2pA:
47.8		 5y9mA-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 8 VAL A  53
LYS A  68
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.72A 5y9mX-1m2pA:
47.9		 5y9mX-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 8 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.29A 5y9mX-1m2pA:
47.9		 5y9mX-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 7 VAL A  53
LYS A  68
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.83A 5yf9B-1m2pA:
47.6		 5yf9B-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 7 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.39A 5yf9B-1m2pA:
47.6		 5yf9B-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 9 VAL A  53
LYS A  68
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.79A 5yf9X-1m2pA:
47.5		 5yf9X-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 9 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.34A 5yf9X-1m2pA:
47.5		 5yf9X-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 1m2p CASEIN KINASE II,
ALPHA CHAIN
(Zea
mays) 		5 / 7 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.30A 5ywmX-1m2pA:
47.2		 5ywmX-1m2pA:
70.59