SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HMO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 10 GLY A 196
ASP A 219
VAL A 223
ASP A 239
ASN A 258
TRP A 259
 SAH  A1699 (-3.8A)
SAH  A1699 (-2.9A)
None
SAH  A1699 (-3.8A)
HMO  A2000 (-3.1A)
None
 0.26A 1fpqA-1fp2A:
22.0		 1fpqA-1fp2A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		4 / 6 ALA A 167
LEU A 123
LEU A 154
LEU A 314
 None
HMO  A2000 (-3.8A)
None
None
 0.89A 1mt1D-1fp2A:
undetectable
1mt1E-1fp2A:
undetectable		 1mt1D-1fp2A:
13.07
1mt1E-1fp2A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 GLY A 196
GLY A 197
GLY A 198
ASP A 239
ASN A 258
TRP A 259
 SAH  A1699 (-3.8A)
SAH  A1699 ( 4.2A)
SAH  A1699 ( 3.9A)
SAH  A1699 (-3.8A)
HMO  A2000 (-3.1A)
None
 0.58A 1qzzA-1fp2A:
26.3		 1qzzA-1fp2A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		7 / 12 TRP A 151
GLY A 196
GLY A 197
GLY A 198
ASP A 239
ASN A 258
TRP A 259
 SAH  A1699 ( 3.8A)
SAH  A1699 (-3.8A)
SAH  A1699 ( 4.2A)
SAH  A1699 ( 3.9A)
SAH  A1699 (-3.8A)
HMO  A2000 (-3.1A)
None
 0.65A 1xdsA-1fp2A:
29.5		 1xdsA-1fp2A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 TRP A 151
GLY A 197
ASP A 239
ASN A 258
TRP A 259
 SAH  A1699 ( 3.8A)
SAH  A1699 ( 4.2A)
SAH  A1699 (-3.8A)
HMO  A2000 (-3.1A)
None
 0.87A 1xdsA-1fp2A:
29.5		 1xdsA-1fp2A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		7 / 12 TRP A 151
GLY A 196
GLY A 197
GLY A 198
ASP A 239
ASN A 258
TRP A 259
 SAH  A1699 ( 3.8A)
SAH  A1699 (-3.8A)
SAH  A1699 ( 4.2A)
SAH  A1699 ( 3.9A)
SAH  A1699 (-3.8A)
HMO  A2000 (-3.1A)
None
 0.58A 1xdsB-1fp2A:
29.1		 1xdsB-1fp2A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 TRP A 151
PHE A 164
MET A 168
GLY A 197
GLY A 198
TRP A 259
 SAH  A1699 ( 3.8A)
HMO  A2000 (-4.9A)
HMO  A2000 ( 4.0A)
SAH  A1699 ( 4.2A)
SAH  A1699 ( 3.9A)
None
 0.63A 3i5uA-1fp2A:
29.6		 3i5uA-1fp2A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 TRP A 151
PHE A 164
MET A 168
GLY A 198
TRP A 259
 SAH  A1699 ( 3.8A)
HMO  A2000 (-4.9A)
HMO  A2000 ( 4.0A)
SAH  A1699 ( 3.9A)
None
 0.98A 3i5uA-1fp2A:
29.6		 3i5uA-1fp2A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1fp2 ISOFLAVONE
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 TRP A 151
MET A 168
GLY A 197
GLY A 198
TRP A 259
 SAH  A1699 ( 3.8A)
HMO  A2000 ( 4.0A)
SAH  A1699 ( 4.2A)
SAH  A1699 ( 3.9A)
None
 0.62A 3i5uB-1fp2A:
29.7		 3i5uB-1fp2A:
25.34