SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HMH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 TRP A 205
TYR A 138
TYR A 164
TYR A  85
 None
HMH  A 301 (-3.3A)
None
None
 1.37A 1nbhB-2gm8A:
undetectable		 1nbhB-2gm8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 TRP A 205
TYR A 138
TYR A 164
TYR A  85
 None
HMH  A 301 (-3.3A)
None
None
 1.37A 1nbhD-2gm8A:
undetectable		 1nbhD-2gm8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 8 GLU A 210
VAL A 142
TRP A  43
GLU A  88
 HMH  A1300 (-2.8A)
None
None
HMH  A1300 ( 4.8A)
 1.02A 1s3zA-2q4xA:
undetectable
1s3zB-2q4xA:
undetectable		 1s3zA-2q4xA:
22.51
1s3zB-2q4xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 GLY A  11
GLU A  44
GLY A  19
THR A  39
VAL A  42
 HMH  A2001 (-3.6A)
HMH  A2001 (-3.0A)
HMH  A2001 ( 3.8A)
None
None
 1.29A 1v3qE-1jxiA:
2.5		 1v3qE-1jxiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		4 / 8 TYR B  47
ASP B  44
TYR B 139
HIS B  21
 HMH  B 302 (-3.7A)
HMH  B 302 (-2.8A)
HMH  B 302 (-3.5A)
None
 1.37A 2ha2A-1to9B:
undetectable		 2ha2A-1to9B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 TYR A  46
ASP A  43
TYR A 138
HIS A  20
 HMH  A 301 (-3.6A)
HMH  A 301 (-2.6A)
HMH  A 301 (-3.3A)
None
 1.37A 2ha2A-2gm8A:
undetectable		 2ha2A-2gm8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		4 / 8 TYR B  47
ASP B  44
TYR B 139
HIS B  21
 HMH  B 302 (-3.7A)
HMH  B 302 (-2.8A)
HMH  B 302 (-3.5A)
None
 1.38A 2ha2B-1to9B:
undetectable		 2ha2B-1to9B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 TYR A  46
ASP A  43
TYR A 138
HIS A  20
 HMH  A 301 (-3.6A)
HMH  A 301 (-2.6A)
HMH  A 301 (-3.3A)
None
 1.38A 2ha2B-2gm8A:
undetectable		 2ha2B-2gm8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A 131
GLU A 122
LEU A 121
TYR A  46
 None
None
None
HMH  A 301 (-3.6A)
 1.21A 2w8yA-2gm8A:
undetectable		 2w8yA-2gm8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 12 GLU A 140
LEU A  18
ILE A 141
PHE A 135
PHE A 194
 None
None
None
HMH  A 301 ( 4.9A)
None
 1.46A 3ko0G-2gm8A:
1.3
3ko0H-2gm8A:
1.3
3ko0I-2gm8A:
1.3
3ko0J-2gm8A:
1.3		 3ko0G-2gm8A:
20.23
3ko0H-2gm8A:
20.23
3ko0I-2gm8A:
20.23
3ko0J-2gm8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ASP A  13
GLY A  17
ALA A  18
ILE A 256
VAL A  49
 None
None
HMH  A2001 ( 4.0A)
None
None
 1.09A 3nu9B-1jxiA:
undetectable		 3nu9B-1jxiA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 9 PHE A 124
ALA A  57
PHE A 135
ALA A  74
THR A  77
 None
None
HMH  A 301 ( 4.9A)
None
None
 1.27A 3t3sA-2gm8A:
0.0		 3t3sA-2gm8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 8 PHE A 124
ALA A  57
PHE A 135
ALA A  74
THR A  77
 None
None
HMH  A 301 ( 4.9A)
None
None
 1.22A 3t3sF-2gm8A:
undetectable		 3t3sF-2gm8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 6 CYH A 213
THR A 214
GLY A  19
ASP A  23
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
 1.20A 3w9tE-1jxiA:
undetectable		 3w9tE-1jxiA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 5 SER A 146
GLU A 210
THR A  22
TYR A  18
 None
HMH  A1300 (-2.8A)
None
None
 1.35A 3zs3A-2q4xA:
undetectable		 3zs3A-2q4xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 11 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.26A 4c5lA-1jxiA:
32.2		 4c5lA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 11 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.52A 4c5lA-1jxiA:
32.2		 4c5lA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 9 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.28A 4c5lB-1jxiA:
31.7		 4c5lB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.52A 4c5lB-1jxiA:
31.7		 4c5lB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.22A 4c5lC-1jxiA:
32.0		 4c5lC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5lC-1jxiA:
32.0		 4c5lC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.25A 4c5lD-1jxiA:
31.8		 4c5lD-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5lD-1jxiA:
31.8		 4c5lD-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		7 / 7 GLY A  11
ASP A  13
GLY A  19
VAL A  42
MET A  80
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.55A 4c5nA-1jxiA:
31.5		 4c5nA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.23A 4c5nB-1jxiA:
31.9		 4c5nB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.51A 4c5nB-1jxiA:
31.9		 4c5nB-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		8 / 8 GLY A  11
ASP A  13
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5nC-1jxiA:
31.3		 4c5nC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.54A 4c5nD-1jxiA:
31.8		 4c5nD-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		5 / 10 ASP A 105
GLY A  11
ILE A  38
VAL A  90
ILE A  78
 SO4  A2003 (-2.9A)
HMH  A2001 (-3.6A)
None
None
None
 1.10A 4dqcA-1jxiA:
undetectable		 4dqcA-1jxiA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  80
GLY A  76
LEU A  47
TYR A 169
TYR A 164
 None
None
HMH  A 301 (-4.6A)
None
None
 1.16A 4lg1C-2gm8A:
undetectable		 4lg1C-2gm8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		4 / 5 ASP A  13
VAL A 107
ASP A 105
GLY A 212
 None
HMH  A2001 ( 4.7A)
SO4  A2003 (-2.9A)
SO4  A2003 (-3.2A)
 1.09A 4xp6A-1jxiA:
0.0		 4xp6A-1jxiA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.08A 5h8tA-1to9B:
undetectable		 5h8tA-1to9B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1jxi PHOSPHOMETHYLPYRIMID
INE KINASE
(Salmonella
enterica) 		6 / 12 VAL A 103
ALA A 220
LYS A  77
ALA A 236
ASP A 187
GLY A  19
 None
None
None
None
None
HMH  A2001 ( 3.8A)
 1.44A 5hesB-1jxiA:
undetectable		 5hesB-1jxiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.09A 5ljbA-1to9B:
undetectable		 5ljbA-1to9B:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 6 GLU A  88
PHE A  57
TYR A 143
PHE A  92
 HMH  A1300 ( 4.8A)
None
HMH  A1300 (-3.6A)
None
 1.40A 5lrbA-2q4xA:
undetectable		 5lrbA-2q4xA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC
(Caulobacter
vibrioides) 		5 / 12 VAL A 418
PRO A 378
GLU A 392
ARG A 377
THR A 311
 None
None
None
HMH  A1001 (-4.6A)
None
 1.43A 5xipD-3epmA:
undetectable		 5xipD-3epmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC
(Caulobacter
vibrioides) 		4 / 7 ARG A 377
HIS A 417
ASP A 374
GLU A 413
 HMH  A1001 (-4.6A)
ZN  A 613 (-3.4A)
None
None
 1.35A 6mn4F-3epmA:
undetectable		 6mn4F-3epmA:
19.74