SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HMG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.43A 1hwiB-1qaxA:
17.9		 1hwiB-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  81
ASN A 267
ALA A 368
LEU A 369
 HMG  A 500 (-3.8A)
HMG  A 500 (-3.8A)
HMG  A 500 ( 3.7A)
HMG  A 500 (-4.7A)
 0.40A 1hwiB-5wpkA:
28.7		 1hwiB-5wpkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.42A 1hwiD-1qaxA:
27.8		 1hwiD-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.42A 1hwiC-1qaxA:
28.1		 1hwiC-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  81
ASN A 267
ALA A 368
LEU A 369
 HMG  A 500 (-3.8A)
HMG  A 500 (-3.8A)
HMG  A 500 ( 3.7A)
HMG  A 500 (-4.7A)
 0.39A 1hwiC-5wpkA:
28.9		 1hwiC-5wpkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.16A 1kiaB-1qaxA:
undetectable		 1kiaB-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.22A 1nbhA-1qaxA:
undetectable		 1nbhA-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.22A 1nbhC-1qaxA:
undetectable		 1nbhC-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.21A 1nbhD-1qaxA:
undetectable		 1nbhD-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 11 GLN A 364
VAL A  87
ALA A  90
SER A  66
VAL A  64
 HMG  A1002 (-4.2A)
None
None
HMG  A1002 ( 4.9A)
None
 1.40A 2c12B-1qaxA:
0.0		 2c12B-1qaxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 10 GLN A 364
VAL A  87
ALA A  90
SER A  66
VAL A  64
 HMG  A1002 (-4.2A)
None
None
HMG  A1002 ( 4.9A)
None
 1.47A 2c12D-1qaxA:
0.0		 2c12D-1qaxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.85A 2f162-2wyaA:
undetectable		 2f162-2wyaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.84A 2f16N-2wyaA:
undetectable		 2f16N-2wyaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 265
ALA A 271
GLY A 358
VAL A  63
ASN A 267
 None
None
None
None
HMG  A 500 (-3.8A)
 1.09A 2okcA-5wpkA:
undetectable		 2okcA-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 265
ALA A 271
GLY A 358
VAL A  63
ASN A 267
 None
None
None
None
HMG  A 500 (-3.8A)
 1.06A 2okcB-5wpkA:
undetectable		 2okcB-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.83A 3mg02-2wyaA:
undetectable
3mg0V-2wyaA:
undetectable		 3mg02-2wyaA:
18.18
3mg0V-2wyaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.84A 3mg0N-2wyaA:
undetectable		 3mg0N-2wyaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 5 ASN A 115
ALA A 116
TYR A 357
ALA A 363
 None
HMG  A 500 (-2.5A)
HMG  A 500 (-4.4A)
None
 1.33A 3twpD-2fa0A:
undetectable		 3twpD-2fa0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASN A 164
ALA A 165
TYR A 412
ALA A 418
 None
HMG  A1509 (-3.1A)
HMG  A1509 ( 4.8A)
None
 1.30A 3twpD-2wyaA:
undetectable		 3twpD-2wyaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 LEU A 319
GLY A 361
VAL A 287
ILE A  86
VAL A  81
 None
None
None
HMG  A1002 ( 4.9A)
None
 1.34A 4okwA-1qaxA:
0.0		 4okwA-1qaxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 8 ASN A 326
LEU A  39
VAL A 254
GLY A 206
 HMG  A 500 (-3.2A)
None
None
HMG  A 500 (-3.7A)
 0.87A 4r3aA-2fa0A:
0.7		 4r3aA-2fa0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.93A 4txnA-1qaxA:
undetectable		 4txnA-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.94A 4txnB-1qaxA:
undetectable		 4txnB-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.95A 4txnC-1qaxA:
undetectable		 4txnC-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.92A 4txnD-1qaxA:
undetectable		 4txnD-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 GLY A 161
TYR A  13
SER A 248
ALA A 149
TYR A 151
 None
None
None
None
HMG  A 500 (-4.1A)
 1.37A 4ymgA-2fa0A:
undetectable		 4ymgA-2fa0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 GLY A 161
TYR A  13
SER A 248
ALA A 149
TYR A 151
 None
None
None
None
HMG  A 500 (-4.1A)
 1.36A 4ymgB-2fa0A:
undetectable		 4ymgB-2fa0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 363
ALA A 365
HIS A 261
LEU A 359
 None
HMG  A 500 (-3.3A)
None
None
 1.11A 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable		 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.81A 5l5zV-2wyaA:
undetectable
5l5zb-2wyaA:
undetectable		 5l5zV-2wyaA:
19.74
5l5zb-2wyaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.81A 5l5zH-2wyaA:
undetectable
5l5zN-2wyaA:
undetectable		 5l5zH-2wyaA:
19.74
5l5zN-2wyaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 303
SER A 375
HIS A 377
PHE A 304
GLY A  89
 HMG  A1509 (-3.7A)
None
None
HMG  A1509 (-4.1A)
None
 0.98A 5l6eA-2wyaA:
undetectable		 5l6eA-2wyaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.88A 5lf3b-2wyaA:
undetectable		 5lf3b-2wyaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.88A 5lf3N-2wyaA:
undetectable		 5lf3N-2wyaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 MET A  93
GLY A  94
SER A 384
TYR A 382
GLN A  90
 None
None
None
HMG  A1509 ( 4.4A)
None
 1.45A 5ttfC-2wyaA:
undetectable		 5ttfC-2wyaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 MET A  93
GLY A  94
SER A 384
TYR A 382
GLN A  90
 None
None
None
HMG  A1509 ( 4.4A)
None
 1.47A 5v9iD-2wyaA:
undetectable		 5v9iD-2wyaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 TRP A 307
SER A 303
GLY A 268
ARG A 261
 None
None
HMG  A1002 (-3.5A)
HMG  A1002 (-3.0A)
 1.07A 6btxA-1qaxA:
undetectable		 6btxA-1qaxA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 GLY A 161
GLY A 160
GLY A  81
HIS A 247
PRO A 202
 None
None
None
HMG  A 500 (-3.3A)
None
 1.06A 6gngB-2fa0A:
undetectable		 6gngB-2fa0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 210
GLY A 209
GLY A 130
HIS A 301
PRO A 251
 None
None
None
HMG  A1509 (-4.1A)
None
 1.11A 6gngB-2wyaA:
undetectable		 6gngB-2wyaA:
21.78