SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HM3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.77A 2nmzA-3rhyA:
undetectable		 2nmzA-3rhyA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.71A 2nnkA-3rhyA:
undetectable		 2nnkA-3rhyA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 130
ARG A 132
PRO A  80
GLY A  81
 None
HM3  A 255 ( 4.2A)
None
None
 1.36A 2y7kB-3rhyA:
undetectable		 2y7kB-3rhyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 130
ARG A 132
PRO A  80
GLY A  81
 None
HM3  A 255 ( 4.2A)
None
None
 1.41A 2y7pA-3rhyA:
undetectable		 2y7pA-3rhyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.63A 3k4vA-3rhyA:
undetectable		 3k4vA-3rhyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.71A 3k4vD-3rhyA:
undetectable		 3k4vD-3rhyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.74A 3ndtA-3rhyA:
undetectable		 3ndtA-3rhyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.77A 3nduD-3rhyA:
undetectable		 3nduD-3rhyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.78A 3pwrA-3rhyA:
undetectable		 3pwrA-3rhyA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.73A 3tl9A-3rhyA:
undetectable		 3tl9A-3rhyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 246
VAL A  64
ARG A  85
ILE A 213
VAL A 208
 None
None
HM3  A 255 ( 4.7A)
None
None
 1.04A 4ok1A-3rhyA:
undetectable		 4ok1A-3rhyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 246
VAL A  64
ARG A  85
ILE A 213
VAL A 208
 None
None
HM3  A 255 ( 4.7A)
None
None
 1.02A 4okwA-3rhyA:
undetectable		 4okwA-3rhyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 117
HIS A 162
LYS A 164
 None
HM3  A 255 (-3.7A)
None
 0.99A 4qzuD-3rhyA:
undetectable		 4qzuD-3rhyA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  66
GLU A  88
PRO A  59
ARG A  85
LEU A  14
 HM3  A 255 (-4.3A)
None
None
HM3  A 255 ( 4.7A)
None
 1.40A 5m50B-3rhyA:
undetectable		 5m50B-3rhyA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  64
ASP A  66
GLU A  88
ARG A  85
LEU A  14
 None
HM3  A 255 (-4.3A)
None
HM3  A 255 ( 4.7A)
None
 1.26A 5m50E-3rhyA:
undetectable		 5m50E-3rhyA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  64
ASP A  66
GLU A  88
ARG A  85
LEU A  14
 None
HM3  A 255 (-4.3A)
None
HM3  A 255 ( 4.7A)
None
 1.08A 5m5cB-3rhyA:
undetectable		 5m5cB-3rhyA:
22.75