SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HKY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		5 / 7 ASP A  54
GLU A  56
TRP A  60
ARG A  69
TRP A  70
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.8A)
HKY  A1080 (-3.6A)
HKY  A1080 (-3.5A)
HKY  A1080 (-3.5A)
 0.78A 1b2iA-4bvwA:
12.5		 1b2iA-4bvwA:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 8 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-4.6A)
HKY  A1080 (-3.5A)
 0.53A 1ceaA-4bvwA:
undetectable
1ceaB-4bvwA:
16.0		 1ceaA-4bvwA:
44.94
1ceaB-4bvwA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 7 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-4.6A)
HKY  A1080 (-3.5A)
 0.53A 1ceaB-4bvwA:
16.0		 1ceaB-4bvwA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 7 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-4.6A)
HKY  A1080 (-3.5A)
 0.64A 1cebA-4bvwA:
16.1		 1cebA-4bvwA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 7 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-4.6A)
HKY  A1080 (-3.5A)
 0.58A 1cebB-4bvwA:
15.9		 1cebB-4bvwA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 7 ASP A  54
TRP A  60
ARG A  69
TRP A  70
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-3.5A)
HKY  A1080 (-3.5A)
 0.50A 2pk4A-4bvwA:
18.1		 2pk4A-4bvwA:
61.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 7 ARG A  35
ASP A  54
TRP A  60
ARG A  69
 CL  A1081 (-3.8A)
HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-3.5A)
 0.78A 3kivA-4bvwA:
18.1		 3kivA-4bvwA:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 7 ASP A  54
TRP A  60
ARG A  69
TRP A  70
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-3.5A)
HKY  A1080 (-3.5A)
 0.32A 3kivA-4bvwA:
18.1		 3kivA-4bvwA:
64.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4bvw APOLIPOPROTEIN(A)
(Homo
sapiens) 		4 / 5 ASN A  52
GLN A   7
ASP A  54
ARG A  35
 None
None
HKY  A1080 (-3.0A)
CL  A1081 (-3.8A)
 1.18A 5w4zA-4bvwA:
undetectable		 5w4zA-4bvwA:
16.67