SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HIU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 8 ASN A 125
TYR A 122
GLY A 145
GLY A  98
 None
None
HIU  A 502 ( 3.7A)
HIU  A 502 ( 3.7A)
 0.80A 1rukH-3bptA:
undetectable
1rukL-3bptA:
undetectable		 1rukH-3bptA:
19.23
1rukL-3bptA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 11 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
 None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
 1.05A 1z11A-3bptA:
undetectable		 1z11A-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 11 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
 None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
 1.05A 1z11B-3bptA:
undetectable		 1z11B-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
 None
None
HIU  A 502 (-2.9A)
None
None
 1.12A 2bm9A-3bptA:
undetectable		 2bm9A-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
 None
None
HIU  A 502 (-2.9A)
None
None
 1.14A 2bm9B-3bptA:
undetectable		 2bm9B-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
 None
None
HIU  A 502 (-2.9A)
None
None
 1.10A 2bm9D-3bptA:
undetectable		 2bm9D-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A  97
VAL A 148
ILE A 103
ASP A  99
LEU A 174
 HIU  A 502 ( 3.5A)
None
None
None
HIU  A 502 (-4.9A)
 1.12A 3cjtG-3bptA:
undetectable		 3cjtG-3bptA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 180
VAL A 178
ILE A 309
SER A 306
ILE A 103
 None
HIU  A 502 (-4.6A)
None
None
None
 1.01A 3frqB-3bptA:
undetectable		 3frqB-3bptA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 122
VAL A 178
ILE A 100
GLY A 146
 None
HIU  A 502 (-4.6A)
QUE  A 501 ( 3.8A)
HIU  A 502 (-2.7A)
 1.00A 3gssA-3bptA:
undetectable		 3gssA-3bptA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 122
VAL A 178
ILE A 100
GLY A 146
 None
HIU  A 502 (-4.6A)
QUE  A 501 ( 3.8A)
HIU  A 502 (-2.7A)
 1.00A 3gssB-3bptA:
undetectable		 3gssB-3bptA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 6 LEU A  60
GLU A 121
ASN A 125
PHE A  94
 None
HIU  A 502 (-2.9A)
None
None
 1.46A 3i9jB-3bptA:
undetectable		 3i9jB-3bptA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 8 CYH A 336
PHE A 342
LEU A 332
ASP A 177
 None
None
None
HIU  A 502 (-2.8A)
 1.06A 3m0wE-3bptA:
0.3
3m0wF-3bptA:
undetectable
3m0wG-3bptA:
undetectable
3m0wH-3bptA:
undetectable		 3m0wE-3bptA:
16.45
3m0wF-3bptA:
16.45
3m0wG-3bptA:
16.45
3m0wH-3bptA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 199
ILE A 142
ALA A  96
MET A 144
GLY A 145
 None
None
QUE  A 501 ( 4.0A)
None
HIU  A 502 ( 3.7A)
 1.04A 4r29D-3bptA:
undetectable		 4r29D-3bptA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A 178
VAL A 148
LEU A 184
LEU A 350
MET A 302
 HIU  A 502 (-4.6A)
None
None
QUE  A 501 (-4.6A)
None
 1.18A 5hv1A-3bptA:
undetectable		 5hv1A-3bptA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 11 PHE A 117
GLY A  98
TYR A 122
ASN A 125
GLY A  97
 None
HIU  A 502 ( 3.7A)
None
None
HIU  A 502 ( 3.5A)
 1.21A 5yjsA-3bptA:
undetectable		 5yjsA-3bptA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 7 GLY A 180
GLY A 179
GLY A 149
GLY A 147
GLY A 146
 None
None
None
None
HIU  A 502 (-2.7A)
 0.84A 6ag0A-3bptA:
undetectable		 6ag0A-3bptA:
13.84