SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HIC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 THR A  74
LEU A 131
GLY A 134
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 0.89A 1gtiD-5ufvA:
undetectable		 1gtiD-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 THR A  74
LEU A 131
GLY A 134
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 0.89A 1gtiE-5ufvA:
undetectable		 1gtiE-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 THR A  74
LEU A 131
GLY A 133
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 1.37A 1gtiF-5ufvA:
undetectable		 1gtiF-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 THR A  74
LEU A 131
GLY A 134
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 0.93A 1gtiF-5ufvA:
undetectable		 1gtiF-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 7 SER A  85
PRO A  83
ALA A 162
TYR A 175
 None
HIC  A   1 ( 4.8A)
None
HIC  A   1 (-4.7A)
 1.02A 1k5qA-2yetA:
undetectable
1k5qB-2yetA:
undetectable		 1k5qA-2yetA:
23.83
1k5qB-2yetA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4eis POLYSACCHARIDE
MONOOXYGENASE-3
(Neurospora
crassa) 		4 / 7 SER B  81
PRO B  79
ALA B 158
TYR B 171
 None
HIC  B   1 ( 3.7A)
None
HIC  B   1 (-3.5A)
 0.98A 1k5qA-4eisB:
undetectable
1k5qB-4eisB:
undetectable		 1k5qA-4eisB:
22.13
1k5qB-4eisB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 4 ASP A  18
ASP A  38
ASP A   6
GLY A   2
 None
None
None
HIC  A   1 ( 2.4A)
 1.12A 2igtC-5o2xA:
undetectable		 2igtC-5o2xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4eis POLYSACCHARIDE
MONOOXYGENASE-3
(Neurospora
crassa) 		4 / 7 ALA B 158
TYR B 171
MET B 131
HIS B 160
 None
HIC  B   1 (-3.5A)
None
None
 1.31A 2pncA-4eisB:
undetectable		 2pncA-4eisB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4eis POLYSACCHARIDE
MONOOXYGENASE-3
(Neurospora
crassa) 		4 / 8 VAL B 205
SER B  81
TYR B 165
TYR B 171
 None
None
None
HIC  B   1 (-3.5A)
 1.00A 2y05A-4eisB:
undetectable
2y05B-4eisB:
undetectable		 2y05A-4eisB:
20.66
2y05B-4eisB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 5 LEU A  41
GLN A   5
THR A  36
HIS A  57
 HIC  A   1 ( 4.9A)
None
None
None
 1.30A 2zj0B-2yetA:
undetectable		 2zj0B-2yetA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 5 LEU A  41
GLN A   5
THR A  36
HIS A  57
 HIC  A   1 ( 4.9A)
None
None
None
 1.34A 2zj0C-2yetA:
undetectable		 2zj0C-2yetA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yet GH61 ISOZYME A
(Thermoascus
aurantiacus) 		4 / 5 LEU A  41
GLN A   5
THR A  36
HIS A  57
 HIC  A   1 ( 4.9A)
None
None
None
 1.32A 3ce6B-2yetA:
undetectable		 3ce6B-2yetA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4eis POLYSACCHARIDE
MONOOXYGENASE-3
(Neurospora
crassa) 		4 / 8 GLN B 169
PRO B  41
PRO B 172
GLU B 155
 HIC  B   1 ( 4.3A)
HIC  B   1 ( 4.6A)
None
None
 1.04A 3oyaA-4eisB:
undetectable		 3oyaA-4eisB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5n05 AUXILIARY ACTIVITY 9
(Lentinus
similis) 		4 / 5 ALA A  75
HIS A  78
GLN A 162
TYR A 164
 BGC  A 305 (-3.6A)
CU  A 301 ( 3.2A)
CL  A 309 (-3.3A)
HIC  A   1 (-3.9A)
 0.77A 4gboA-5n05A:
7.7		 4gboA-5n05A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5n05 AUXILIARY ACTIVITY 9
(Lentinus
similis) 		4 / 5 ALA A  75
HIS A  78
GLN A 162
TYR A 164
 BGC  A 305 (-3.6A)
CU  A 301 ( 3.2A)
CL  A 309 (-3.3A)
HIC  A   1 (-3.9A)
 1.06A 4gboB-5n05A:
7.8		 4gboB-5n05A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5t7k AOAA13
(Aspergillus
oryzae) 		4 / 7 GLY A   2
PHE A 218
ASP A  90
PHE A 166
 HIC  A   1 ( 2.3A)
None
None
None
 0.92A 5hieA-5t7kA:
undetectable		 5hieA-5t7kA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 5n05 AUXILIARY ACTIVITY 9
(Lentinus
similis) 		4 / 5 ALA A  75
HIS A  78
GLN A 162
TYR A 164
 BGC  A 305 (-3.6A)
CU  A 301 ( 3.2A)
CL  A 309 (-3.3A)
HIC  A   1 (-3.9A)
 0.73A 5uizA-5n05A:
7.8		 5uizA-5n05A:
20.32