SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HHH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 GLU A 297
ARG A 324
ASP A 160
THR A 214
 None
None
None
HHH  A4114 (-3.1A)
 1.43A 1k4tA-2r5vA:
undetectable		 1k4tA-2r5vA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 GLU A 297
ARG A 324
ASP A 160
THR A 214
 None
None
None
HHH  A4114 (-3.1A)
 1.41A 1rr8C-2r5vA:
undetectable		 1rr8C-2r5vA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 GLU A 297
ARG A 324
ASP A 160
THR A 214
 None
None
None
HHH  A4114 (-3.1A)
 1.42A 1rrjA-2r5vA:
undetectable		 1rrjA-2r5vA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ILE A 317
ILE A 335
ILE A 216
VAL A 203
HIS A 161
 None
HHH  A4114 (-4.3A)
None
None
CO  A4113 ( 3.3A)
 1.04A 2qo5A-2r5vA:
undetectable		 2qo5A-2r5vA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 8 LEU A 303
ILE A 216
THR A 214
GLN A 240
 None
None
HHH  A4114 (-3.1A)
None
 0.97A 5ljbA-2r5vA:
undetectable		 5ljbA-2r5vA:
15.60