SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HH3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 PHE A 531
GLN A 516
ASN A 804
ASN A 733
 None
HH3  A   1 ( 4.7A)
None
None
 1.26A 2nyrA-3fw0A:
undetectable		 2nyrA-3fw0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 ARG A 706
TYR A 654
ASP A 800
ARG A 533
 HH3  A   1 (-3.2A)
HH3  A   1 ( 3.9A)
None
HH3  A   1 (-2.7A)
 1.30A 4kr4C-3fw0A:
undetectable		 4kr4C-3fw0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 PHE A 581
ASN A 579
ARG A 533
GLY A 534
 None
None
HH3  A   1 (-2.7A)
None
 0.82A 5o4yA-3fw0A:
undetectable		 5o4yA-3fw0A:
9.52