SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HH2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		4 / 8 GLY A 186
HIS A 146
ALA A 199
ILE A 187
 HH2  A 282 ( 4.9A)
None
None
None
 0.76A 1gtnP-1twwA:
undetectable
1gtnQ-1twwA:
undetectable		 1gtnP-1twwA:
13.47
1gtnQ-1twwA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		4 / 6 ASP A 101
GLY A  24
ILE A  22
ILE A 118
 HH2  A 282 (-3.4A)
None
None
None
 0.90A 1n49D-1twwA:
undetectable		 1n49D-1twwA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		6 / 12 ASP A 101
ASN A 120
ILE A 143
ASP A 184
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.1A)
HH2  A 282 (-3.3A)
None
 0.63A 1q8jA-1twwA:
22.6		 1q8jA-1twwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 ASP A 101
ASN A 120
ILE A 143
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.3A)
None
 0.63A 1q8jB-1twwA:
21.8		 1q8jB-1twwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 LEU A 203
LEU A 206
ASN A 207
LEU A 209
LEU A 214
 None
None
None
None
HH2  A 282 ( 4.9A)
 1.16A 1sqnB-1twwA:
undetectable		 1sqnB-1twwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 LEU A 203
LEU A 206
ASN A 207
LEU A 209
LEU A 214
 None
None
None
None
HH2  A 282 ( 4.9A)
 1.14A 1ya3C-1twwA:
undetectable		 1ya3C-1twwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		4 / 5 ILE A 246
ILE A 143
ILE A  22
LEU A 206
 None
HH2  A 282 (-4.1A)
None
None
 0.94A 1zgyA-1twwA:
undetectable		 1zgyA-1twwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		4 / 8 LEU A 214
ILE A 182
LEU A  21
ILE A  22
 HH2  A 282 ( 4.9A)
None
None
None
 0.91A 2azxA-1twwA:
undetectable		 2azxA-1twwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 ASP A 101
ASN A 120
ILE A 143
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.3A)
None
 0.63A 2e7fA-1twwA:
23.3		 2e7fA-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 ASP A 101
ASN A 120
ILE A 143
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.3A)
None
 0.68A 2ogyA-1twwA:
23.2		 2ogyA-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 ASP A 101
ASN A 120
ILE A 143
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.3A)
None
 0.71A 2ogyB-1twwA:
23.2		 2ogyB-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 ASP A  61
ASN A 120
ILE A 143
ASP A 184
GLY A 216
 None
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.1A)
HH2  A 282 (-3.3A)
 1.17A 2ycjA-1twwA:
23.2		 2ycjA-1twwA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		6 / 12 ASP A 101
ASN A 120
ILE A 143
ASP A 184
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.1A)
HH2  A 282 (-3.3A)
None
 0.70A 2ycjA-1twwA:
23.2		 2ycjA-1twwA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		4 / 5 VAL A 253
ILE A 143
MET A 160
ARG A 219
 None
HH2  A 282 (-4.1A)
None
SO4  A 279 (-3.3A)
 1.44A 3oezA-1twwA:
0.2		 3oezA-1twwA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		3 / 3 PHE A 189
LYS A 220
SER A 221
 HH2  A 282 (-4.8A)
HH2  A 282 (-2.9A)
SO4  A 281 (-3.7A)
 0.51A 3tyeB-1twwA:
45.5		 3tyeB-1twwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		4 / 8 GLY A 188
PHE A 189
LYS A 220
SER A 221
 None
HH2  A 282 (-4.8A)
HH2  A 282 (-2.9A)
SO4  A 281 (-3.7A)
 0.57A 3tzfB-1twwA:
36.3		 3tzfB-1twwA:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		6 / 12 ASP A  61
ASP A 101
ASN A 120
ASP A 184
GLY A 216
SER A 218
 None
HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-3.1A)
HH2  A 282 (-3.3A)
None
 0.80A 4djeB-1twwA:
23.1		 4djeB-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		6 / 12 ASP A  61
ASP A 101
ASN A 120
ILE A 143
GLY A 216
SER A 218
 None
HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.3A)
None
 0.71A 4djfB-1twwA:
23.3		 4djfB-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 GLY A 216
ILE A  22
SER A 262
LEU A 214
THR A  20
 HH2  A 282 (-3.3A)
None
None
HH2  A 282 ( 4.9A)
None
 1.34A 4pooA-1twwA:
undetectable		 4pooA-1twwA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		5 / 12 LEU A 214
ILE A 122
GLY A  63
ILE A  62
ILE A 143
 HH2  A 282 ( 4.9A)
HH2  A 282 (-4.6A)
None
None
HH2  A 282 (-4.1A)
 0.85A 5e5jB-1twwA:
undetectable		 5e5jB-1twwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		3 / 3 ASP A 101
ASN A 120
ASP A 184
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-3.1A)
 0.33A 5vopA-1twwA:
19.8		 5vopA-1twwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1tww DHPS,
DIHYDROPTEROATE
SYNTHASE
(Bacillus
anthracis) 		3 / 3 ASP A 101
ASN A 120
ASP A 184
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-3.1A)
 0.36A 5vopB-1twwA:
19.6		 5vopB-1twwA:
23.72