SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HH0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 LEU E 155
ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
None
HH0  E 327 (-4.1A)
None
None
 0.99A 1hsgA-1qrpE:
6.7		 1hsgA-1qrpE:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 LEU E 155
ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
None
HH0  E 327 (-4.1A)
None
None
 0.95A 1sdtA-1qrpE:
6.6		 1sdtA-1qrpE:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1qrp PEPSIN 3A
(Homo
sapiens) 		4 / 5 ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
HH0  E 327 (-4.1A)
None
None
 0.98A 2aoiA-1qrpE:
6.6		 2aoiA-1qrpE:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 7 LEU E 155
ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
None
HH0  E 327 (-4.1A)
None
None
 1.09A 2aojB-1qrpE:
6.8		 2aojB-1qrpE:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 9 LEU E 155
ASP E 303
ILE E 213
GLY E  34
VAL E 153
 None
None
None
HH0  E 327 (-4.1A)
None
 1.01A 2avoA-1qrpE:
6.7		 2avoA-1qrpE:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		9 / 12 VAL E  30
ASP E  32
GLY E  34
SER E  35
TYR E  75
PHE E 117
ASP E 215
GLY E 217
SER E 219
 HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
HH0  E 327 ( 4.8A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.0A)
 0.48A 2v0zC-1qrpE:
44.5		 2v0zC-1qrpE:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		8 / 12 VAL E  30
ASP E  32
GLY E  34
ALA E 115
PHE E 117
ASP E 215
GLY E 217
SER E 219
 HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
None
HH0  E 327 ( 4.8A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.0A)
 0.56A 2v0zO-1qrpE:
44.8		 2v0zO-1qrpE:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 SER E 163
ILE E 192
ASP E 215
THR E  33
PHE E 260
 None
None
HH0  E 327 (-2.5A)
None
None
 1.29A 3a25A-1qrpE:
undetectable		 3a25A-1qrpE:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ASP E  32
GLY E  34
THR E  77
PHE E 117
ASP E 215
SER E 219
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 ( 4.8A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.0A)
 0.77A 3d91A-1qrpE:
44.8		 3d91A-1qrpE:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ASP E  32
GLY E  34
THR E  77
ASP E 215
SER E 219
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.0A)
 0.46A 3d91B-1qrpE:
44.5		 3d91B-1qrpE:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ASP E  32
GLY E  34
THR E  77
VAL E  30
ASP E 215
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 ( 4.7A)
HH0  E 327 (-2.5A)
 1.07A 3d91B-1qrpE:
44.5		 3d91B-1qrpE:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ILE E 235
LEU E 221
GLN E 287
ARG E 307
LEU E 276
 None
None
HH0  E 327 ( 3.6A)
None
None
 1.08A 3ix9B-1qrpE:
undetectable		 3ix9B-1qrpE:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1qrp PEPSIN 3A
(Homo
sapiens) 		4 / 8 GLU E 297
ASN E 290
MET E 289
ILE E 228
 None
None
HH0  E 327 ( 4.1A)
None
 1.22A 3kp6A-1qrpE:
undetectable
3kp6B-1qrpE:
undetectable		 3kp6A-1qrpE:
17.25
3kp6B-1qrpE:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 11 LEU E 155
ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
None
HH0  E 327 (-4.1A)
None
None
 0.96A 3oxxD-1qrpE:
6.5		 3oxxD-1qrpE:
15.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ASP E  32
GLY E  34
GLY E  76
ASP E 215
THR E 218
ILE E 300
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 0.42A 3prsA-1qrpE:
38.8		 3prsA-1qrpE:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ASP E  32
GLY E  76
ILE E 213
THR E 218
ILE E 300
 HH0  E 327 (-2.7A)
HH0  E 327 (-3.2A)
None
HH0  E 327 (-3.7A)
None
 0.37A 3pwwA-1qrpE:
38.7		 3pwwA-1qrpE:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 8 GLY E  34
SER E  35
ILE E  73
TYR E  75
ASP E 215
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.1A)
None
HH0  E 327 (-4.5A)
HH0  E 327 (-2.5A)
 0.34A 3pwwA-1qrpE:
38.7		 3pwwA-1qrpE:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ASP E  32
GLY E  34
GLY E  76
ASP E 215
THR E 218
ILE E 300
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 0.31A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ILE E 120
ASP E  32
GLY E  34
ASP E 215
THR E 218
ILE E 300
 None
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 1.21A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ILE E 120
ASP E  32
ILE E  73
ASP E 215
THR E 218
ILE E 300
 None
HH0  E 327 (-2.7A)
None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 1.33A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ILE E 213
ASP E 215
GLY E 217
GLY E  76
ASP E  32
ILE E 120
 None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.7A)
None
 0.74A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1qrp PEPSIN 3A
(Homo
sapiens) 		4 / 6 SER E  35
ILE E  73
TYR E  75
ASP E 118
 HH0  E 327 (-4.1A)
None
HH0  E 327 (-4.5A)
None
 0.98A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ASP E  32
GLY E  34
ILE E  73
GLY E  76
ASP E 215
ILE E 300
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
None
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
None
 0.50A 3tneA-1qrpE:
37.4		 3tneA-1qrpE:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ILE E 213
ASP E 215
GLY E 217
ASP E  32
ILE E 120
 None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-2.7A)
None
 0.54A 3tneA-1qrpE:
37.4		 3tneA-1qrpE:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ILE E 213
ASP E 215
GLY E 217
GLY E  76
ASP E  32
 None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.7A)
 0.74A 3tneA-1qrpE:
37.4		 3tneA-1qrpE:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		6 / 12 ASP E  32
GLY E  34
ILE E  73
GLY E  76
ASP E 215
ILE E 300
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
None
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
None
 0.55A 3tneB-1qrpE:
37.5		 3tneB-1qrpE:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ILE E 213
ASP E 215
GLY E 217
ASP E  32
ILE E 120
 None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-2.7A)
None
 0.56A 3tneB-1qrpE:
37.5		 3tneB-1qrpE:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 ILE E 213
ASP E 215
GLY E 217
GLY E  76
ASP E  32
 None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.7A)
 0.72A 3tneB-1qrpE:
37.5		 3tneB-1qrpE:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		4 / 7 SER E  35
TYR E  75
ILE E 120
THR E 218
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
HH0  E 327 (-3.7A)
 0.33A 3tneB-1qrpE:
37.5		 3tneB-1qrpE:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 ASP E 215
GLY E 217
GLY E  76
LEU E 298
ILE E 300
 HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.2A)
HH0  E 327 ( 4.9A)
None
 0.83A 3ttpA-1qrpE:
7.0		 3ttpA-1qrpE:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 ASP E 215
GLY E 217
GLY E  76
LEU E 298
ILE E 300
 HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.2A)
HH0  E 327 ( 4.9A)
None
 0.81A 3ttpB-1qrpE:
6.9		 3ttpB-1qrpE:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 12 PHE E 111
ASP E  32
GLY E 302
SER E 219
GLN E 287
 HH0  E 327 (-4.6A)
HH0  E 327 (-2.7A)
None
HH0  E 327 (-3.0A)
HH0  E 327 ( 3.6A)
 1.08A 4djeB-1qrpE:
undetectable		 4djeB-1qrpE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.80A 4k8cA-1qrpE:
undetectable		 4k8cA-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.79A 4kahA-1qrpE:
undetectable		 4kahA-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.79A 4kahB-1qrpE:
undetectable		 4kahB-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.79A 4kanA-1qrpE:
undetectable		 4kanA-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.81A 4kanB-1qrpE:
undetectable		 4kanB-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.83A 4kbeA-1qrpE:
undetectable		 4kbeA-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.80A 4kbeB-1qrpE:
undetectable		 4kbeB-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.80A 4lbgA-1qrpE:
undetectable		 4lbgA-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 SER E  35
TYR E  75
PRO E 135
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
None
 0.79A 4lbgB-1qrpE:
undetectable		 4lbgB-1qrpE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 ASP E 215
ASP E  32
ASN E  37
 HH0  E 327 (-2.5A)
HH0  E 327 (-2.7A)
None
 0.52A 4q5mA-1qrpE:
10.2		 4q5mA-1qrpE:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 9 ALA E 115
PHE E 117
ILE E  73
GLY E  78
SER E 219
 None
HH0  E 327 ( 4.8A)
None
None
HH0  E 327 (-3.0A)
 1.05A 4r20B-1qrpE:
undetectable		 4r20B-1qrpE:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 11 PHE E 305
ILE E 306
LEU E   6
ASP E  32
GLY E 217
 None
None
None
HH0  E 327 (-2.7A)
HH0  E 327 (-3.5A)
 1.30A 5fctA-1qrpE:
0.0		 5fctA-1qrpE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1qrp PEPSIN 3A
(Homo
sapiens) 		3 / 3 LEU E   6
VAL E  30
ASP E  32
 None
HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
 0.65A 5x23A-1qrpE:
undetectable		 5x23A-1qrpE:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 PHE E 305
ILE E 306
LEU E   6
ASP E  32
GLY E 217
 None
None
None
HH0  E 327 (-2.7A)
HH0  E 327 (-3.5A)
 1.36A 6r2eB-1qrpE:
0.0		 6r2eB-1qrpE:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 PHE E 305
ILE E 306
LEU E   6
ASP E  32
GLY E 217
 None
None
None
HH0  E 327 (-2.7A)
HH0  E 327 (-3.5A)
 1.37A 6r2eC-1qrpE:
0.0		 6r2eC-1qrpE:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1qrp PEPSIN 3A
(Homo
sapiens) 		5 / 10 PHE E 305
ILE E 306
LEU E   6
ASP E  32
GLY E 217
 None
None
None
HH0  E 327 (-2.7A)
HH0  E 327 (-3.5A)
 1.32A 6r2eD-1qrpE:
0.0		 6r2eD-1qrpE:
21.86