SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HGS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PIW_A_T3A933_1 (ANDROGEN RECEPTOR)	3kal	HOMOGLUTATHIONE SYNTHETASE (Glycine max)	5 / 10	ILE A 180 GLY A 452 GLU A 169 ASN A 171 ARG A 295	None None MG A 502 (-1.9A) MG A 502 (-2.9A) HGS A 501 (-3.7A)	1.37A	2piwA-3kalA: undetectable	2piwA-3kalA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_B_BCZB468_1 (NEURAMINIDASE)	3kal	HOMOGLUTATHIONE SYNTHETASE (Glycine max)	3 / 3	ARG A 153 GLU A 246 TYR A 293	HGS A 501 ( 2.8A) None None	0.91A	3k37B-3kalA: undetectable	3k37B-3kalA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PP7_B_SVRB499_1 (PYRUVATE KINASE)	3kal	HOMOGLUTATHIONE SYNTHETASE (Glycine max)	5 / 10	THR A 175 PRO A 324 ARG A 153 ASN A 171 GLY A 332	HGS A 501 (-4.7A) None HGS A 501 ( 2.8A) MG A 502 (-2.9A) MG A 504 (-3.8A)	1.43A	3pp7B-3kalA: undetectable	3pp7B-3kalA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	3kal	HOMOGLUTATHIONE SYNTHETASE (Glycine max)	3 / 3	LEU A 76 PRO A 77 ARG A 153	None None HGS A 501 ( 2.8A)	0.61A	4klrB-3kalA: undetectable	4klrB-3kalA: 21.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PIW_A_T3A933_1","ANDROGEN RECEPTOR","3kal","HOMOGLUTATHIONE SYNTHETASE","Glycine max",5,"ILE A 180;GLY A 452;GLU A 169;ASN A 171;ARG A 295","None;None; MG A 502 (-1.9A); MG A 502 (-2.9A);HGS A 501 (-3.7A)","1.37A","2piwA-3kalA:undetectable",null],["3K37_B_BCZB468_1","NEURAMINIDASE","3kal","HOMOGLUTATHIONE SYNTHETASE","Glycine max",3,"ARG A 153;GLU A 246;TYR A 293","HGS A 501 ( 2.8A);None;None","0.91A","3k37B-3kalA:undetectable","2piwA-3kalA:18.70"],["3PP7_B_SVRB499_1","PYRUVATE KINASE","3kal","HOMOGLUTATHIONE SYNTHETASE","Glycine max",5,"THR A 175;PRO A 324;ARG A 153;ASN A 171;GLY A 332","HGS A 501 (-4.7A);None;HGS A 501 ( 2.8A); MG A 502 (-2.9A); MG A 504 (-3.8A)","1.43A","3pp7B-3kalA:undetectable","3k37B-3kalA:18.77"],["4KLR_B_CHDB504_0","FERROCHELATASE, MITOCHONDRIAL","3kal","HOMOGLUTATHIONE SYNTHETASE","Glycine max",3,"LEU A  76;PRO A  77;ARG A 153","None;None;HGS A 501 ( 2.8A)","0.61A","4klrB-3kalA:undetectable","3pp7B-3kalA:21.28"]]