SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HGA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_0 (PUTATIVE RRNA METHYLASE)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	5 / 12	GLY A 134 ILE A 182 GLY A 181 GLN A 172 THR A 187	None HGA A 301 (-3.9A) None HGA A 301 ( 4.6A) HGA A 301 (-3.6A)	1.18A	3eeyE-5tv7A: undetectable	3eeyE-5tv7A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_F_SAMF300_0 (PUTATIVE RRNA METHYLASE)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	5 / 12	GLY A 134 ILE A 182 GLY A 181 GLN A 172 THR A 187	None HGA A 301 (-3.9A) None HGA A 301 ( 4.6A) HGA A 301 (-3.6A)	1.19A	3eeyF-5tv7A: undetectable	3eeyF-5tv7A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U8Q_A_NPUA7231_1 (LACTOTRANSFERRIN)	1xfg	GLUCOSAMINE--FRUCTOS E-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] (Escherichia coli)	4 / 5	THR A 122 GLY A 78 PRO A 80 ASN A 84	HGA A5300 ( 4.6A) None None None	1.05A	3u8qA-1xfgA: undetectable	3u8qA-1xfgA: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1477_0 (TRANSLATION ELONGATION FACTOR SELB)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	4 / 6	THR A 127 GLY A 184 ILE A 131 LEU A 191	None HGA A 301 (-3.3A) None None	1.04A	4acbC-5tv7A: undetectable	4acbC-5tv7A: 17.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EEY_E_SAME300_0","PUTATIVE RRNA METHYLASE","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",5,"GLY A 134;ILE A 182;GLY A 181;GLN A 172;THR A 187","None;HGA A 301 (-3.9A);None;HGA A 301 ( 4.6A);HGA A 301 (-3.6A)","1.18A","3eeyE-5tv7A:undetectable",null],["3EEY_F_SAMF300_0","PUTATIVE RRNA METHYLASE","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",5,"GLY A 134;ILE A 182;GLY A 181;GLN A 172;THR A 187","None;HGA A 301 (-3.9A);None;HGA A 301 ( 4.6A);HGA A 301 (-3.6A)","1.19A","3eeyF-5tv7A:undetectable","3eeyE-5tv7A:19.23"],["3U8Q_A_NPUA7231_1","LACTOTRANSFERRIN","1xfg","GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING]","Escherichia coli",4,"THR A 122;GLY A  78;PRO A  80;ASN A  84","HGA A5300 ( 4.6A);None;None;None","1.05A","3u8qA-1xfgA:undetectable","3eeyF-5tv7A:19.23"],["4ACB_C_DXCC1477_0","TRANSLATION ELONGATION FACTOR SELB","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",4,"THR A 127;GLY A 184;ILE A 131;LEU A 191","None;HGA A 301 (-3.3A);None;None","1.04A","4acbC-5tv7A:undetectable","3u8qA-1xfgA:21.19"]]