SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HFG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.04A 1jhoA-4ydqA:
undetectable		 1jhoA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 0.98A 1jhoA-5xioA:
undetectable		 1jhoA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.05A 1jhoA-5xipA:
undetectable		 1jhoA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.05A 1jhrA-4ydqA:
undetectable		 1jhrA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 1.00A 1jhrA-5xioA:
undetectable		 1jhrA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.06A 1jhrA-5xipA:
undetectable		 1jhrA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.06A 1jhyA-4ydqA:
undetectable		 1jhyA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 1.00A 1jhyA-5xioA:
undetectable		 1jhyA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.06A 1jhyA-5xipA:
undetectable		 1jhyA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.06A 1l4nA-4ydqA:
undetectable		 1l4nA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 1.00A 1l4nA-5xioA:
undetectable		 1l4nA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.05A 1l4nA-5xipA:
undetectable		 1l4nA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.04A 1l5kA-4ydqA:
undetectable		 1l5kA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 0.98A 1l5kA-5xioA:
undetectable		 1l5kA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.04A 1l5kA-5xipA:
undetectable		 1l5kA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.04A 1l5lA-4ydqA:
undetectable		 1l5lA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 0.98A 1l5lA-5xioA:
undetectable		 1l5lA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.04A 1l5lA-5xipA:
undetectable		 1l5lA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.04A 1l5mA-4ydqA:
undetectable		 1l5mA-4ydqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 0.98A 1l5mA-5xioA:
undetectable		 1l5mA-5xioA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.04A 1l5mA-5xipA:
undetectable		 1l5mA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 7 PHE A 458
SER A 434
THR A 331
GLY A 428
 None
None
HFG  A 801 (-3.4A)
None
 0.83A 2v0mB-5xioA:
undetectable		 2v0mB-5xioA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
ARG A 357
GLU A 409
ASN A 386
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 4.9A)
None
 1.23A 2w13A-4ydqA:
undetectable		 2w13A-4ydqA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
ARG A 357
GLU A 409
ASN A 386
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 4.8A)
None
 1.16A 2w13A-5xipA:
undetectable		 2w13A-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 12 GLU A 392
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.91A 4hvcA-4ydqA:
50.6		 4hvcA-4ydqA:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.36A 4hvcA-4ydqA:
50.6		 4hvcA-4ydqA:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.71A 4hvcA-4ydqA:
50.6		 4hvcA-4ydqA:
51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.10A 4hvcA-5xioA:
50.6		 4hvcA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
GLU A 381
PHE A 426
GLY A 482
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 (-3.9A)
 0.69A 4hvcA-5xioA:
50.6		 4hvcA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 PHE A 307
VAL A 311
PRO A 330
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
GLY A 482
 HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.42A 4hvcA-5xioA:
50.6		 4hvcA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.98A 4hvcA-5xipA:
50.3		 4hvcA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.63A 4hvcA-5xipA:
50.3		 4hvcA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.0A)
 0.24A 4hvcA-4ydqA:
50.6		 4hvcA-4ydqA:
51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
ARG A 362
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-4.2A)
 0.26A 4hvcA-5xioA:
50.6		 4hvcA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-3.5A)
 0.35A 4hvcA-5xipA:
50.3		 4hvcA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 12 GLU A 392
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.95A 4hvcB-4ydqA:
50.8		 4hvcB-4ydqA:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.38A 4hvcB-4ydqA:
50.8		 4hvcB-4ydqA:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.68A 4hvcB-4ydqA:
50.8		 4hvcB-4ydqA:
51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.12A 4hvcB-5xioA:
49.4		 4hvcB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
GLU A 381
PHE A 426
THR A 450
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 0.64A 4hvcB-5xioA:
49.4		 4hvcB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
VAL A 311
PRO A 330
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.38A 4hvcB-5xioA:
49.4		 4hvcB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.02A 4hvcB-5xipA:
50.2		 4hvcB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.61A 4hvcB-5xipA:
50.2		 4hvcB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 5 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.0A)
 0.22A 4hvcB-4ydqA:
50.8		 4hvcB-4ydqA:
51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 5 THR A 331
GLU A 333
ARG A 362
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-4.2A)
 0.27A 4hvcB-5xioA:
49.4		 4hvcB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 5 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-3.5A)
 0.38A 4hvcB-5xipA:
50.2		 4hvcB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 8 ARG A 390
PHE A 405
GLN A 475
THR A 478
THR A 512
ARG A 514
 ANP  A 801 ( 2.5A)
ANP  A 801 (-3.9A)
ANP  A 801 (-4.4A)
HFG  A 802 ( 4.0A)
ANP  A 801 (-3.1A)
ANP  A 801 (-3.2A)
 0.45A 4k87A-4ydqA:
49.4		 4k87A-4ydqA:
49.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 GLU A 392
PRO A 358
THR A 359
GLU A 361
ARG A 390
GLU A 409
PHE A 454
HIS A 480
SER A 508
 ANP  A 801 (-3.6A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 (-4.0A)
HFG  A 802 ( 3.8A)
 1.41A 4k88A-4ydqA:
49.1		 4k88A-4ydqA:
49.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
GLU A 409
PHE A 454
HIS A 480
SER A 508
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 (-4.0A)
HFG  A 802 ( 3.8A)
 0.66A 4k88A-4ydqA:
49.1		 4k88A-4ydqA:
49.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
PHE A 454
HIS A 480
SER A 508
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 (-4.0A)
HFG  A 802 ( 3.8A)
 0.80A 4k88A-4ydqA:
49.1		 4k88A-4ydqA:
49.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		8 / 12 GLU A 364
THR A 331
GLU A 333
ARG A 362
GLU A 381
PHE A 426
HIS A 452
SER A 480
 ANP  A 803 (-3.7A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 (-4.2A)
HFG  A 801 ( 3.8A)
 1.45A 4k88A-5xioA:
51.1		 4k88A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		12 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
TRP A 379
GLU A 381
PHE A 426
HIS A 452
SER A 480
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 (-4.2A)
HFG  A 801 ( 3.8A)
 0.52A 4k88A-5xioA:
51.1		 4k88A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		8 / 12 GLU A 392
THR A 359
GLU A 361
ARG A 390
GLU A 409
PHE A 454
HIS A 480
SER A 508
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
HFG  A1003 (-3.5A)
HFG  A1003 ( 3.9A)
 1.31A 4k88A-5xipA:
48.9		 4k88A-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
GLU A 409
PHE A 454
HIS A 480
SER A 508
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
HFG  A1003 (-3.5A)
HFG  A1003 ( 3.9A)
 0.74A 4k88A-5xipA:
48.9		 4k88A-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A 802 (-3.2A)
None
HFG  A 802 ( 3.8A)
HFG  A 802 (-2.9A)
HFG  A 802 (-3.7A)
 1.09A 4kqiA-4ydqA:
undetectable		 4kqiA-4ydqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 9 THR A 331
GLY A 382
SER A 480
GLU A 333
GLY A 482
 HFG  A 801 (-3.4A)
None
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.0A)
HFG  A 801 (-3.9A)
 1.03A 4kqiA-5xioA:
undetectable		 4kqiA-5xioA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 9 THR A 359
GLY A 410
SER A 508
GLU A 361
GLY A 510
 HFG  A1003 (-3.9A)
None
HFG  A1003 ( 3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 3.9A)
 1.09A 4kqiA-5xipA:
undetectable		 4kqiA-5xipA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 7 VAL A 311
PRO A 309
LYS A 366
GLU A 364
 HFG  A 801 (-4.3A)
None
None
ANP  A 803 (-3.7A)
 1.02A 4lb2A-5xioA:
undetectable		 4lb2A-5xioA:
7.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
None
HFG  A 802 (-3.7A)
 1.14A 4olfA-4ydqA:
54.2		 4olfA-4ydqA:
97.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
TRP A 509
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
None
HFG  A 802 (-3.7A)
 0.30A 4olfA-4ydqA:
54.2		 4olfA-4ydqA:
97.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
PHE A 454
THR A 478
SER A 508
TRP A 509
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
None
HFG  A 802 (-3.7A)
 0.61A 4olfA-4ydqA:
54.2		 4olfA-4ydqA:
97.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 PHE A 335
HIS A 411
PHE A 454
THR A 460
SER A 508
 HFG  A 802 (-3.4A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
None
HFG  A 802 ( 3.8A)
 1.40A 4olfA-4ydqA:
54.2		 4olfA-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		8 / 12 GLU A 364
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
TRP A 481
GLY A 482
 ANP  A 803 (-3.7A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
None
HFG  A 801 (-3.9A)
 1.21A 4olfA-5xioA:
52.7		 4olfA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
TRP A 379
GLU A 381
PHE A 426
THR A 450
GLY A 482
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 0.59A 4olfA-5xioA:
52.7		 4olfA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 PHE A 307
VAL A 311
PRO A 330
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
TRP A 481
GLY A 482
 HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
None
HFG  A 801 (-3.9A)
 0.38A 4olfA-5xioA:
52.7		 4olfA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 GLU A 338
VAL A 339
PRO A 358
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
TRP A 509
GLY A 510
 MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
None
HFG  A1003 ( 3.9A)
 0.33A 4olfA-5xipA:
51.4		 4olfA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		8 / 12 GLU A 392
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
None
HFG  A1003 ( 3.9A)
 1.11A 4olfA-5xipA:
51.4		 4olfA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
None
HFG  A1003 ( 3.9A)
 0.58A 4olfA-5xipA:
51.4		 4olfA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.0A)
 0.27A 4olfA-4ydqA:
54.2		 4olfA-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
ARG A 362
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-4.2A)
 0.34A 4olfA-5xioA:
52.7		 4olfA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-3.5A)
 0.47A 4olfA-5xipA:
51.4		 4olfA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 12 GLU A 392
THR A 359
ARG A 390
HIS A 411
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.34A 4q15A-4ydqA:
52.1		 4q15A-4ydqA:
97.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
HIS A 411
PHE A 454
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.56A 4q15A-4ydqA:
52.1		 4q15A-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
TRP A 379
HIS A 383
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.45A 4q15A-5xioA:
49.3		 4q15A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
THR A 331
ARG A 362
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.60A 4q15A-5xioA:
49.3		 4q15A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
VAL A 311
PRO A 330
THR A 331
ARG A 362
TRP A 379
HIS A 383
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.38A 4q15A-5xioA:
49.3		 4q15A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
TRP A 407
HIS A 411
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.28A 4q15A-5xipA:
53.1		 4q15A-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
HIS A 411
PHE A 454
SER A 508
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.51A 4q15A-5xipA:
53.1		 4q15A-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.30A 4q15A-4ydqA:
52.1		 4q15A-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.58A 4q15A-5xioA:
31.6		 4q15A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.23A 4q15A-5xipA:
35.6		 4q15A-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
THR A 359
ARG A 390
GLU A 409
PHE A 454
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.32A 4q15B-4ydqA:
52.8		 4q15B-4ydqA:
97.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.53A 4q15B-4ydqA:
52.8		 4q15B-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
TRP A 379
GLU A 381
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.35A 4q15B-5xioA:
48.8		 4q15B-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		12 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
THR A 331
ARG A 362
TRP A 379
GLU A 381
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.54A 4q15B-5xioA:
48.8		 4q15B-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
TRP A 407
GLU A 409
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.26A 4q15B-5xipA:
50.1		 4q15B-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.52A 4q15B-5xipA:
50.1		 4q15B-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.34A 4q15B-4ydqA:
52.8		 4q15B-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.61A 4q15B-5xioA:
48.8		 4q15B-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.22A 4q15B-5xipA:
50.1		 4q15B-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 12 TYR A 287
VAL A 292
ILE A 335
SER A 359
VAL A 311
 None
None
None
None
HFG  A 801 (-4.3A)
 1.30A 4rujA-5xioA:
undetectable		 4rujA-5xioA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
ARG A 390
GLU A 409
HIS A 411
PHE A 454
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.29A 4ydqA-4ydqA:
59.3		 4ydqA-4ydqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.00A 4ydqA-4ydqA:
59.3		 4ydqA-4ydqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
GLU A 381
HIS A 383
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.39A 4ydqA-5xioA:
50.6		 4ydqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
GLU A 381
HIS A 383
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.51A 4ydqA-5xioA:
50.6		 4ydqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
TRP A 379
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.77A 4ydqA-5xioA:
50.6		 4ydqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
ARG A 390
TRP A 407
GLU A 409
HIS A 411
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.37A 4ydqA-5xipA:
51.8		 4ydqA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
SER A 508
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.74A 4ydqA-5xipA:
51.8		 4ydqA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.31A 4ydqA-4ydqA:
59.3		 4ydqA-4ydqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.53A 4ydqA-5xioA:
50.6		 4ydqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.34A 4ydqA-5xipA:
51.8		 4ydqA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
THR A 359
ARG A 390
GLU A 409
HIS A 411
PHE A 454
SER A 508
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
 1.34A 4ydqB-4ydqA:
54.6		 4ydqB-4ydqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.47A 4ydqB-4ydqA:
54.6		 4ydqB-4ydqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 GLU A 310
VAL A 311
PRO A 330
THR A 331
ARG A 362
TRP A 379
HIS A 383
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.73A 4ydqB-5xioA:
50.9		 4ydqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
THR A 331
ARG A 362
GLU A 381
HIS A 383
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.45A 4ydqB-5xioA:
50.9		 4ydqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
THR A 331
ARG A 362
GLU A 381
HIS A 383
PHE A 426
SER A 480
GLY A 482
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.53A 4ydqB-5xioA:
50.9		 4ydqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
SER A 508
GLY A 510
 MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.62A 4ydqB-5xipA:
51.8		 4ydqB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
GLU A 409
HIS A 411
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.31A 4ydqB-5xipA:
51.8		 4ydqB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
GLU A 409
HIS A 411
PHE A 454
SER A 508
GLY A 510
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.63A 4ydqB-5xipA:
51.8		 4ydqB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.30A 4ydqB-4ydqA:
54.6		 4ydqB-4ydqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.52A 4ydqB-5xioA:
50.9		 4ydqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.19A 4ydqB-5xipA:
51.8		 4ydqB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 5 THR A 460
GLY A 457
GLU A 361
HIS A 411
 None
None
HFG  A1003 (-2.9A)
HFG  A1003 ( 4.7A)
 1.25A 5c0oH-5xipA:
undetectable		 5c0oH-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 GLU A 392
ARG A 390
GLU A 409
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.31A 5f9zA-4ydqA:
49.8		 5f9zA-4ydqA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.31A 5f9zA-4ydqA:
49.8		 5f9zA-4ydqA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
PHE A 454
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.64A 5f9zA-4ydqA:
49.8		 5f9zA-4ydqA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
TRP A 379
GLU A 381
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.31A 5f9zA-5xioA:
50.9		 5f9zA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		8 / 12 LEU A 297
GLU A 310
VAL A 311
PRO A 330
ARG A 362
GLU A 381
PHE A 426
GLY A 482
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 (-3.9A)
 0.60A 5f9zA-5xioA:
50.9		 5f9zA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 LEU A 297
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.27A 5f9zA-5xioA:
50.9		 5f9zA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		6 / 12 GLU A 392
ARG A 390
TRP A 407
GLU A 409
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.20A 5f9zA-5xipA:
50.2		 5f9zA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		10 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.36A 5f9zA-5xipA:
50.2		 5f9zA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.41A 5f9zA-4ydqA:
49.8		 5f9zA-4ydqA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.53A 5f9zA-5xioA:
50.9		 5f9zA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.38A 5f9zA-5xipA:
50.2		 5f9zA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 GLU A 392
ARG A 390
GLU A 409
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.30A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.35A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
PHE A 454
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.67A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
TRP A 379
GLU A 381
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.30A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		8 / 12 LEU A 297
GLU A 310
VAL A 311
PRO A 330
ARG A 362
PHE A 426
SER A 480
GLY A 482
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.64A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 LEU A 297
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.30A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		6 / 12 GLU A 392
ARG A 390
TRP A 407
GLU A 409
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.20A 5f9zB-5xipA:
50.8		 5f9zB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		10 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.35A 5f9zB-5xipA:
50.8		 5f9zB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.39A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.52A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.41A 5f9zB-5xipA:
50.8		 5f9zB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.52A 5xioA-4ydqA:
50.6		 5xioA-4ydqA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.77A 5xioA-4ydqA:
50.6		 5xioA-4ydqA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 12 PHE A 307
GLU A 310
HIS A 383
THR A 432
SER A 480
 HFG  A 801 (-3.7A)
None
HFG  A 801 ( 4.7A)
None
HFG  A 801 ( 3.8A)
 1.38A 5xioA-5xioA:
60.2		 5xioA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		12 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
GLY A 482
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.00A 5xioA-5xioA:
60.2		 5xioA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.59A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		6 / 12 GLU A 392
ARG A 390
GLU A 409
HIS A 411
THR A 478
SER A 508
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 1.42A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.82A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 THR A 359
GLU A 361
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 (-4.0A)
 0.13A 5xioA-4ydqA:
50.6		 5xioA-4ydqA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 THR A 331
GLU A 333
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
HFG  A 801 (-4.2A)
 0.01A 5xioA-5xioA:
60.2		 5xioA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 THR A 359
GLU A 361
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 (-3.5A)
 0.31A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		8 / 12 GLU A 392
PRO A 358
THR A 359
ARG A 390
GLU A 409
HIS A 411
PHE A 454
HIS A 480
 ANP  A 801 (-3.6A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 (-4.0A)
 1.20A 5xioB-4ydqA:
50.7		 5xioB-4ydqA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
HIS A 480
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.44A 5xioB-4ydqA:
50.7		 5xioB-4ydqA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
PHE A 454
THR A 478
HIS A 480
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.67A 5xioB-4ydqA:
50.7		 5xioB-4ydqA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 GLU A 364
THR A 331
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
HIS A 452
 ANP  A 803 (-3.7A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 1.23A 5xioB-5xioA:
56.6		 5xioB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		12 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
THR A 331
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
HIS A 452
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.34A 5xioB-5xioA:
56.6		 5xioB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		11 / 12 GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
HIS A 480
 MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.49A 5xioB-5xipA:
51.3		 5xioB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
GLU A 409
HIS A 411
THR A 478
HIS A 480
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 1.16A 5xioB-5xipA:
51.3		 5xioB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		10 / 12 PHE A 335
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
HIS A 411
THR A 478
HIS A 480
 HFG  A1003 (-3.8A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.70A 5xioB-5xipA:
51.3		 5xioB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
THR A 359
ARG A 390
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.32A 5xipA-4ydqA:
51.8		 5xipA-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.32A 5xipA-4ydqA:
51.8		 5xipA-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
HIS A 411
THR A 478
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.57A 5xipA-4ydqA:
51.8		 5xipA-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
HIS A 383
THR A 450
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.49A 5xipA-5xioA:
50.3		 5xipA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
GLU A 310
VAL A 311
PRO A 330
THR A 331
ARG A 362
HIS A 383
PHE A 426
THR A 450
SER A 480
GLY A 482
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.57A 5xipA-5xioA:
50.3		 5xipA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
THR A 331
ARG A 362
HIS A 383
THR A 450
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.80A 5xipA-5xioA:
50.3		 5xipA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.24A 5xipA-5xipA:
62.1		 5xipA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.00A 5xipA-5xipA:
62.1		 5xipA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 GLU A 361
TRP A 407
HIS A 480
 HFG  A 802 (-2.9A)
None
HFG  A 802 (-4.0A)
 0.99A 5xipA-4ydqA:
50.7		 5xipA-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 GLU A 333
TRP A 379
HIS A 452
 HFG  A 801 (-3.0A)
None
HFG  A 801 (-4.2A)
 0.27A 5xipA-5xioA:
50.3		 5xipA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 GLU A 361
TRP A 407
HIS A 480
 HFG  A1003 (-2.9A)
HFG  A1003 (-4.7A)
HFG  A1003 (-3.5A)
 0.00A 5xipA-5xipA:
62.1		 5xipA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
THR A 359
ARG A 390
HIS A 411
PHE A 454
THR A 478
HIS A 480
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 1.23A 5xipB-4ydqA:
51.6		 5xipB-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
HIS A 411
PHE A 454
THR A 478
HIS A 480
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.71A 5xipB-4ydqA:
51.6		 5xipB-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 GLU A 310
VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
HIS A 383
PHE A 426
THR A 450
HIS A 452
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.61A 5xipB-5xioA:
50.9		 5xipB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
ARG A 362
TRP A 379
HIS A 383
THR A 450
HIS A 452
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 1.37A 5xipB-5xioA:
50.9		 5xipB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
HIS A 383
THR A 450
HIS A 452
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.75A 5xipB-5xioA:
50.9		 5xipB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 PHE A 307
VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
TRP A 379
HIS A 383
THR A 450
HIS A 452
 HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.60A 5xipB-5xioA:
50.9		 5xipB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
TRP A 379
HIS A 383
PHE A 426
THR A 450
HIS A 452
 HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.42A 5xipB-5xioA:
50.9		 5xipB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 12 VAL A 311
PRO A 330
THR A 331
HIS A 383
PHE A 458
 HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 ( 4.7A)
None
 1.28A 5xipB-5xioA:
50.9		 5xipB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
TRP A 407
HIS A 411
THR A 478
HIS A 480
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 1.15A 5xipB-5xipA:
56.8		 5xipB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
HIS A 411
PHE A 454
THR A 478
HIS A 480
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.36A 5xipB-5xipA:
56.8		 5xipB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		6 / 12 VAL A 339
PRO A 358
THR A 359
GLU A 361
HIS A 411
PHE A 486
 HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 ( 4.7A)
None
 1.47A 5xipB-5xipA:
56.8		 5xipB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 12 GLU A 392
THR A 359
GLU A 409
HIS A 411
THR A 478
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-3.7A)
 1.04A 5xipC-4ydqA:
50.6		 5xipC-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-3.7A)
 0.60A 5xipC-4ydqA:
50.6		 5xipC-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 VAL A 339
PRO A 358
THR A 359
GLU A 409
PHE A 486
 HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 ( 4.9A)
None
 1.19A 5xipC-4ydqA:
50.6		 5xipC-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 GLU A 364
TRP A 379
GLU A 381
HIS A 383
THR A 450
GLY A 482
 ANP  A 803 (-3.7A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 1.11A 5xipC-5xioA:
50.6		 5xipC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 LEU A 297
GLU A 310
VAL A 311
THR A 331
PHE A 426
THR A 450
GLY A 482
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 0.67A 5xipC-5xioA:
50.6		 5xipC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
VAL A 311
PRO A 330
THR A 331
GLU A 333
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
GLY A 482
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 0.31A 5xipC-5xioA:
50.6		 5xipC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		5 / 12 VAL A 311
PRO A 330
THR A 331
GLU A 381
PHE A 458
 HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 ( 4.9A)
None
 1.19A 5xipC-5xioA:
50.6		 5xipC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
TRP A 407
GLU A 409
HIS A 411
THR A 478
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 1.04A 5xipC-5xipA:
54.5		 5xipC-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
GLY A 510
 None
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 0.26A 5xipC-5xipA:
54.5		 5xipC-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		5 / 12 VAL A 339
PRO A 358
THR A 359
GLU A 409
PHE A 486
 HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 ( 4.8A)
None
 1.18A 5xipC-5xipA:
54.5		 5xipC-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 12 GLU A 392
THR A 359
GLU A 361
ARG A 390
GLU A 409
TRP A 509
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
None
 1.40A 5xipD-4ydqA:
50.6		 5xipD-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		12 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
GLU A 409
PHE A 454
THR A 478
TRP A 509
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
None
 0.61A 5xipD-4ydqA:
50.6		 5xipD-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 12 VAL A 339
PRO A 358
THR A 359
GLU A 409
PHE A 486
TRP A 509
 HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 ( 4.9A)
None
None
 1.34A 5xipD-4ydqA:
50.6		 5xipD-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
THR A 331
ARG A 362
TRP A 379
GLU A 381
THR A 450
TRP A 481
 ANP  A 803 (-3.7A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
ANP  A 803 (-3.9A)
None
 1.43A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 LEU A 297
GLU A 310
VAL A 311
THR A 331
GLU A 333
ARG A 362
TRP A 379
PHE A 426
THR A 450
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
 0.65A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
TRP A 379
GLU A 381
PHE A 426
THR A 450
TRP A 481
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
None
 0.39A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		6 / 12 VAL A 311
PRO A 330
THR A 331
GLU A 381
PHE A 458
TRP A 481
 HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 ( 4.9A)
None
None
 1.42A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
THR A 359
ARG A 390
TRP A 407
GLU A 409
THR A 478
TRP A 509
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
ANP  A1001 ( 3.7A)
None
 1.31A 5xipD-5xipA:
54.4		 5xipD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
GLU A 409
PHE A 454
THR A 478
TRP A 509
 None
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
None
 0.34A 5xipD-5xipA:
54.4		 5xipD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		6 / 12 VAL A 339
PRO A 358
THR A 359
GLU A 409
PHE A 486
TRP A 509
 HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 ( 4.8A)
None
None
 1.36A 5xipD-5xipA:
54.4		 5xipD-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.05A 5xiqA-4ydqA:
53.1		 5xiqA-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.32A 5xiqA-4ydqA:
53.1		 5xiqA-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.66A 5xiqA-4ydqA:
53.1		 5xiqA-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.09A 5xiqA-5xioA:
51.7		 5xiqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
TRP A 379
GLU A 381
PHE A 426
THR A 450
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.59A 5xiqA-5xioA:
51.7		 5xiqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
VAL A 311
PRO A 330
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
GLY A 482
 None
HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.41A 5xiqA-5xioA:
51.7		 5xiqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.93A 5xiqA-5xipA:
52.9		 5xiqA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.51A 5xiqA-5xipA:
52.9		 5xiqA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.0A)
 0.12A 5xiqA-4ydqA:
53.1		 5xiqA-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
ARG A 362
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-4.2A)
 0.23A 5xiqA-5xioA:
51.7		 5xiqA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-3.5A)
 0.30A 5xiqA-5xipA:
52.9		 5xiqA-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
 ANP  A 801 (-3.6A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
 1.24A 5xiqB-4ydqA:
52.6		 5xiqB-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
 0.34A 5xiqB-4ydqA:
52.6		 5xiqB-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
PHE A 454
THR A 478
SER A 508
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
 0.65A 5xiqB-4ydqA:
52.6		 5xiqB-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
ARG A 362
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
 1.33A 5xiqB-5xioA:
51.2		 5xiqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
PHE A 426
THR A 450
SER A 480
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
 0.55A 5xiqB-5xioA:
51.2		 5xiqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
 None
HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
 0.37A 5xiqB-5xioA:
51.2		 5xiqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
ARG A 390
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 1.18A 5xiqB-5xipA:
52.4		 5xiqB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 0.57A 5xiqB-5xipA:
52.4		 5xiqB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 THR A 359
GLU A 361
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 (-4.0A)
 0.19A 5xiqB-4ydqA:
52.6		 5xiqB-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 THR A 331
GLU A 333
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
HFG  A 801 (-4.2A)
 0.11A 5xiqB-5xioA:
51.2		 5xiqB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 THR A 359
GLU A 361
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 (-3.5A)
 0.28A 5xiqB-5xipA:
52.4		 5xiqB-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		8 / 12 GLU A 392
THR A 359
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
 1.31A 5xiqC-4ydqA:
52.5		 5xiqC-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
 0.29A 5xiqC-4ydqA:
52.5		 5xiqC-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		10 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
PHE A 454
THR A 478
SER A 508
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
 0.66A 5xiqC-4ydqA:
52.5		 5xiqC-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
ARG A 362
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
 1.42A 5xiqC-5xioA:
51.3		 5xiqC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		9 / 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
PHE A 426
THR A 450
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
 0.59A 5xiqC-5xioA:
51.3		 5xiqC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 PHE A 307
VAL A 311
PRO A 330
THR A 331
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
 HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
 0.39A 5xiqC-5xioA:
51.3		 5xiqC-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
ARG A 390
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 1.27A 5xiqC-5xipA:
52.4		 5xiqC-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 PHE A 335
GLU A 338
VAL A 339
PRO A 358
THR A 359
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 0.56A 5xiqC-5xipA:
52.4		 5xiqC-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
GLY A 510
 ANP  A 801 (-3.6A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-3.7A)
 1.32A 5xiqD-4ydqA:
52.7		 5xiqD-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-3.7A)
 0.37A 5xiqD-4ydqA:
52.7		 5xiqD-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
PHE A 454
THR A 478
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-3.7A)
 0.66A 5xiqD-4ydqA:
52.7		 5xiqD-4ydqA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
THR A 460
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
None
 1.34A 5xiqD-4ydqA:
52.7		 5xiqD-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		7 / 12 GLU A 364
ARG A 362
TRP A 379
GLU A 381
HIS A 383
THR A 450
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 1.35A 5xiqD-5xioA:
51.5		 5xiqD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		12 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 (-3.9A)
 0.59A 5xiqD-5xioA:
51.5		 5xiqD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
ARG A 390
TRP A 407
GLU A 409
HIS A 411
THR A 478
GLY A 510
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 1.17A 5xiqD-5xipA:
53.0		 5xiqD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 0.47A 5xiqD-5xipA:
53.0		 5xiqD-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		3 / 3 THR A 359
GLU A 361
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 (-4.0A)
 0.16A 5xiqD-4ydqA:
52.7		 5xiqD-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		3 / 3 THR A 331
GLU A 333
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
HFG  A 801 (-4.2A)
 0.11A 5xiqD-5xioA:
51.5		 5xiqD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		3 / 3 THR A 359
GLU A 361
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 (-3.5A)
 0.27A 5xiqD-5xipA:
53.0		 5xiqD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 6 VAL A 367
LEU A 380
LEU A 382
HIS A 411
 None
None
None
HFG  A 802 (-4.5A)
 0.96A 6e43B-4ydqA:
undetectable		 6e43B-4ydqA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		7 / 12 GLU A 392
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 ANP  A 801 (-3.6A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
None
HFG  A 802 (-3.7A)
 1.04A 6mn8A-4ydqA:
44.3		 6mn8A-4ydqA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		11 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
None
HFG  A 802 (-3.7A)
 0.43A 6mn8A-4ydqA:
44.3		 6mn8A-4ydqA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		9 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
THR A 478
TRP A 509
GLY A 510
 None
HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
None
HFG  A 802 ( 4.0A)
None
HFG  A 802 (-3.7A)
 0.70A 6mn8A-4ydqA:
44.3		 6mn8A-4ydqA:
50.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		8 / 12 GLU A 364
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
TRP A 481
GLY A 482
 ANP  A 803 (-3.7A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
None
HFG  A 801 (-3.9A)
 1.10A 6mn8A-5xioA:
43.8		 6mn8A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		10 / 12 LEU A 297
PHE A 307
GLU A 310
VAL A 311
PRO A 330
TRP A 379
GLU A 381
HIS A 383
TRP A 481
GLY A 482
 None
HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
None
HFG  A 801 (-3.9A)
 0.52A 6mn8A-5xioA:
43.8		 6mn8A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		11 / 12 LEU A 297
PHE A 307
VAL A 311
PRO A 330
TRP A 379
GLU A 381
HIS A 383
THR A 450
SER A 480
TRP A 481
GLY A 482
 None
HFG  A 801 (-3.7A)
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
None
HFG  A 801 (-3.9A)
 0.44A 6mn8A-5xioA:
43.8		 6mn8A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		7 / 12 GLU A 392
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 ANP  A1001 (-3.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
None
HFG  A1003 ( 3.9A)
 0.94A 6mn8A-5xipA:
44.7		 6mn8A-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		12 / 12 LEU A 325
PHE A 335
GLU A 338
VAL A 339
PRO A 358
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
TRP A 509
GLY A 510
 None
HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
None
HFG  A1003 ( 3.9A)
 0.62A 6mn8A-5xipA:
44.7		 6mn8A-5xipA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 4ydq PROLINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 (-4.0A)
 0.45A 6mn8A-4ydqA:
44.3		 6mn8A-4ydqA:
50.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)
(Cryptosporidium
parvum) 		4 / 4 THR A 331
GLU A 333
ARG A 362
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-4.2A)
 0.45A 6mn8A-5xioA:
43.8		 6mn8A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE
(Eimeria
tenella) 		4 / 4 THR A 359
GLU A 361
ARG A 390
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-3.5A)
 0.54A 6mn8A-5xipA:
44.7		 6mn8A-5xipA:
undetectable