SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HF2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4m73 METHYLTRANSFERASE
MPPJ
(Streptomyces
hygroscopicus) 		4 / 5 ASP A 309
THR A 304
LEU A 305
LYS A 322
 HF2  A 404 ( 3.3A)
None
None
HF2  A 404 ( 3.0A)
 1.47A 4a3pA-4m73A:
undetectable		 4a3pA-4m73A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4m73 METHYLTRANSFERASE
MPPJ
(Streptomyces
hygroscopicus) 		5 / 10 SER A 104
GLY A 103
TRP A  99
ILE A 139
PHE A 312
 None
None
M72  A 402 (-4.5A)
M72  A 402 ( 4.6A)
HF2  A 404 (-4.4A)
 1.09A 5zjiA-4m73A:
undetectable
5zjiJ-4m73A:
undetectable		 5zjiA-4m73A:
12.73
5zjiJ-4m73A:
8.65